Angela R Ozburn1,2,3, Aaron J Janowsky1,2,4,5, John C Crabbe1,2,3. 1. Research & Development Service, Portland VA Medical Center, Portland, Oregon. 2. Department of Behavioral Neuroscience, School of Medicine, Oregon Health & Science University, Portland, Oregon. 3. Portland Alcohol Research Center, Oregon Health & Science University, Portland, Oregon. 4. Department of Psychiatry, School of Medicine, Oregon Health & Science University, Portland, Oregon. 5. Methamphetamine Abuse Research Center, Oregon Health & Science University, Portland, Oregon.
Abstract
BACKGROUND: Alcohol abuse is comorbid with abuse of many other drugs, some with similar pharmacology and others quite different. This leads to the hypothesis of an underlying, unitary dysfunctional neurobiological basis for substance abuse risk and consequences. METHODS: In this review, we discuss commonalities and distinctions of addiction to alcohol and other drugs. We focus on recent advances in preclinical studies using rodent models of drug self-administration. RESULTS: While there are specific behavioral and molecular manifestations common to alcohol, psychostimulant, opioid, and nicotine dependence, attempts to propose a unifying theory of the addictions inevitably face details where distinctions are found among classes of drugs. CONCLUSIONS: For alcohol, versus other drugs of abuse, we discuss and compare advances in: (i) neurocircuitry important for the different stages of drug dependence; (ii) transcriptomics and genetical genomics; and (iii) enduring effects, noting in particular the contributions of behavioral genetics and animal models.
BACKGROUND:Alcohol abuse is comorbid with abuse of many other drugs, some with similar pharmacology and others quite different. This leads to the hypothesis of an underlying, unitary dysfunctional neurobiological basis for substance abuse risk and consequences. METHODS: In this review, we discuss commonalities and distinctions of addiction to alcohol and other drugs. We focus on recent advances in preclinical studies using rodent models of drug self-administration. RESULTS: While there are specific behavioral and molecular manifestations common to alcohol, psychostimulant, opioid, and nicotine dependence, attempts to propose a unifying theory of the addictions inevitably face details where distinctions are found among classes of drugs. CONCLUSIONS: For alcohol, versus other drugs of abuse, we discuss and compare advances in: (i) neurocircuitry important for the different stages of drug dependence; (ii) transcriptomics and genetical genomics; and (iii) enduring effects, noting in particular the contributions of behavioral genetics and animal models.
Authors: J R Bunzow; M S Sonders; S Arttamangkul; L M Harrison; G Zhang; D I Quigley; T Darland; K L Suchland; S Pasumamula; J L Kennedy; S B Olson; R E Magenis; S G Amara; D K Grandy Journal: Mol Pharmacol Date: 2001-12 Impact factor: 4.436
Authors: Andrew K Haack; Chandni Sheth; Andrea L Schwager; Michael S Sinclair; Shashank Tandon; Sharif A Taha Journal: PLoS One Date: 2014-04-02 Impact factor: 3.240
Authors: Angela R Ozburn; Pamela Metten; Sheena Potretzke; Kayla G Townsley; Yuri A Blednov; John C Crabbe Journal: Alcohol Clin Exp Res Date: 2020-01-13 Impact factor: 3.455
Authors: Kush Purohit; Puja K Parekh; Joseph Kern; Ryan W Logan; Zheng Liu; Yanhua Huang; Colleen A McClung; John C Crabbe; Angela R Ozburn Journal: Alcohol Clin Exp Res Date: 2018-04-18 Impact factor: 3.455
Authors: Laura B Ferguson; Angela R Ozburn; Igor Ponomarev; Pamela Metten; Matthew Reilly; John C Crabbe; R Adron Harris; R Dayne Mayfield Journal: Neuropsychopharmacology Date: 2017-12-18 Impact factor: 7.853