Literature DB >> 26429293

Candida lusitaniae MICs to the echinocandins are elevated but FKS-mediated resistance is rare.

Shawn R Lockhart1, Cau D Pham2, Randall J Kuykendall2, Carol B Bolden2, Angela A Cleveland2.   

Abstract

MIC values were generated for caspofungin, micafungin, and anidulafungin against 106 isolates of C. lusitaniae, and these values were compared to established epidemiologic cutoff values. The majority of isolates were wild type both by MIC value as well as by FKS1 hotspot sequencing. Although C. lusitaniae isolates have MIC values to the echinocandins that are elevated compared to other common species, with regard to known mechanisms of resistance to the echinocandins, isolates with MIC values at or below the epidemiological cutoff values of 0.5 and 1 μg/mL for micafungin and anidulafungin, respectively, should be considered wild type. Published by Elsevier Inc.

Entities:  

Keywords:  Candida lusitaniae; Echinocandin; Epidemiological cutoff value; FKS

Mesh：

Substances：

Year:  2015        PMID： 26429293      PMCID： PMC5939560          DOI： 10.1016/j.diagmicrobio.2015.08.012

Source DB:  PubMed          Journal:  Diagn Microbiol Infect Dis        ISSN： 0732-8893            Impact factor:   2.803


  26 in total

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Journal:  Int J Antimicrob Agents       Date:  2011-04-22       Impact factor: 5.283

2.  Interlaboratory variability of Caspofungin MICs for Candida spp. Using CLSI and EUCAST methods: should the clinical laboratory be testing this agent?

Authors:  A Espinel-Ingroff; M C Arendrup; M A Pfaller; L X Bonfietti; B Bustamante; E Canton; E Chryssanthou; M Cuenca-Estrella; E Dannaoui; A Fothergill; J Fuller; P Gaustad; G M Gonzalez; J Guarro; C Lass-Flörl; S R Lockhart; J F Meis; C B Moore; L Ostrosky-Zeichner; T Pelaez; S R B S Pukinskas; G St-Germain; M W Szeszs; J Turnidge
Journal:  Antimicrob Agents Chemother       Date:  2013-09-09       Impact factor: 5.191

Review 3.  Epidemiology and outcomes of candidemia in 3648 patients: data from the Prospective Antifungal Therapy (PATH Alliance®) registry, 2004-2008.

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Journal:  Diagn Microbiol Infect Dis       Date:  2012-10-25       Impact factor: 2.803

4.  Multilaboratory study of epidemiological cutoff values for detection of resistance in eight Candida species to fluconazole, posaconazole, and voriconazole.

Authors:  A Espinel-Ingroff; M A Pfaller; B Bustamante; E Canton; A Fothergill; J Fuller; G M Gonzalez; C Lass-Flörl; S R Lockhart; E Martin-Mazuelos; J F Meis; M S C Melhem; L Ostrosky-Zeichner; T Pelaez; M W Szeszs; G St-Germain; L X Bonfietti; J Guarro; J Turnidge
Journal:  Antimicrob Agents Chemother       Date:  2014-01-13       Impact factor: 5.191

Review 5.  Relative frequency of albicans and the various non-albicans Candida spp among candidemia isolates from inpatients in various parts of the world: a systematic review.

Authors:  Matthew E Falagas; Nikos Roussos; Konstantinos Z Vardakas
Journal:  Int J Infect Dis       Date:  2010-08-24       Impact factor: 3.623

6.  Antifungal susceptibility testing of Candida isolates from the Candida surveillance study.

Authors:  G Marshall Lyon; Sulaiman Karatela; Susan Sunay; Yaffa Adiri
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7.  In vitro activity of seven systemically active antifungal agents against a large global collection of rare Candida species as determined by CLSI broth microdilution methods.

Authors:  D J Diekema; S A Messer; L B Boyken; R J Hollis; J Kroeger; S Tendolkar; M A Pfaller
Journal:  J Clin Microbiol       Date:  2009-08-26       Impact factor: 5.948

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Authors:  M A Pfaller; L Boyken; R J Hollis; J Kroeger; S A Messer; S Tendolkar; R N Jones; J Turnidge; D J Diekema
Journal:  J Clin Microbiol       Date:  2009-11-18       Impact factor: 5.948

Review 9.  Candidemia in intensive care unit: a nationwide prospective observational survey (GISIA-3 study) and review of the European literature from 2000 through 2013.

Authors:  M T Montagna; G Lovero; E Borghi; G Amato; S Andreoni; L Campion; G Lo Cascio; G Lombardi; F Luzzaro; E Manso; M Mussap; P Pecile; S Perin; E Tangorra; M Tronci; R Iatta; G Morace
Journal:  Eur Rev Med Pharmacol Sci       Date:  2014       Impact factor: 3.507

10.  Nosocomial bloodstream infections due to Candida spp. in the USA: species distribution, clinical features and antifungal susceptibilities.

Authors:  Hilmar Wisplinghoff; Jenny Ebbers; Lea Geurtz; Danuta Stefanik; Yvette Major; Michael B Edmond; Richard P Wenzel; Harald Seifert
Journal:  Int J Antimicrob Agents       Date:  2013-10-12       Impact factor: 5.283
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2.  Candida lusitaniae in Kuwait: Prevalence, antifungal susceptibility and role in neonatal fungemia.

Authors:  Ziauddin Khan; Suhail Ahmad; Noura Al-Sweih; Seema Khan; Leena Joseph
Journal:  PLoS One       Date:  2019-03-07       Impact factor: 3.240

3.  Species distribution and susceptibility profiles of Candida species isolated from vulvovaginal candidiasis, emergence of C. lusitaniae.

Authors:  Seyed Ebrahim Hashemi; Tahereh Shokohi; Mahdi Abastabar; Narges Aslani; Mahbobeh Ghadamzadeh; Iman Haghani
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4.  zzm321990 Candida lusitaniae Breakthrough Fungemia in an Immuno-Compromised Adolescent: Case Report and Review of the Literature.

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  4 in total

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