Literature DB >> 26428386

The Biology and Clinical Utility of EBV Monitoring in Blood.

Jennifer Kanakry1, Richard Ambinder2.   

Abstract

Epstein-Barr virus (EBV) DNA in blood can be quantified in peripheral blood mononuclear cells, in circulating cell-free (CCF) DNA specimens, or in whole blood. CCF viral DNA may be actively released or extruded from viable cells, packaged in virions or passively shed from cells during apoptosis or necrosis. In infectious mononucleosis, viral DNA is detected in each of these kinds of specimens, although it is only transiently detected in CCF specimens. In nasopharyngeal carcinoma, CCF EBV DNA is an established tumor marker. In EBV-associated Hodgkin lymphoma and in EBV-associated extranodal NK-/T-cell lymphoma, there is growing evidence for the utility of CCF DNA as a tumor marker.

Entities:  

Keywords:  Circulating cell‐free DNA; EBV monitoring; Nasopharyngeal cancer; Plasma EBV DNA; Tumor marker

Mesh：

Substances：

Year:  2015        PMID： 26428386     DOI： 10.1007/978-3-319-22834-1_17

Source DB:  PubMed          Journal:  Curr Top Microbiol Immunol        ISSN： 0070-217X            Impact factor:   4.291


  10 in total

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Authors:  Satish Gopal; Thomas G Gross
Journal:  Blood       Date:  2018-05-16       Impact factor: 22.113

2.  Determination of Epstein-Barr Virus-Infected Lymphocyte Cell Types in Peripheral Blood Mononuclear Cells as a Valuable Diagnostic Tool in Hematological Diseases.

Authors:  Peiling Zhang; Chen Zeng; Jiali Cheng; Jing Zhou; Jia Gu; Xia Mao; Wei Zhang; Yang Cao; Hui Luo; Bin Xu; Qinlu Li; Min Xiao; Jianfeng Zhou
Journal:  Open Forum Infect Dis       Date:  2019-04-04       Impact factor: 3.835

Review 3.  Plasma Epstein-Barr virus DNA as an archetypal circulating tumour DNA marker.

Authors:  Wai Kei Jacky Lam; Kwan Chee Allen Chan; Yuk Ming Dennis Lo
Journal:  J Pathol       Date:  2019-02-25       Impact factor: 7.996

4.  Methylation analysis of plasma DNA informs etiologies of Epstein-Barr virus-associated diseases.

Authors:  W K Jacky Lam; Peiyong Jiang; K C Allen Chan; Wenlei Peng; Huimin Shang; Macy M S Heung; Suk Hang Cheng; Haiqiang Zhang; O Y Olivia Tse; Radha Raghupathy; Brigette B Y Ma; Edwin P Hui; Anthony T C Chan; John K S Woo; Rossa W K Chiu; Y M Dennis Lo
Journal:  Nat Commun       Date:  2019-07-22       Impact factor: 14.919

5.  Validation of a Highly Sensitive qPCR Assay for the Detection of Plasma Cell-Free Epstein-Barr Virus DNA in Nasopharyngeal Carcinoma Diagnosis.

Authors:  Vu Nguyen Quynh Anh; Nguyen Van Ba; Do Tram Anh; Nguyen Dinh Ung; Nguyen Hoang Hiep; Vu Thi Ly; Dinh Thi Thu Hang; Bui Tien Sy; Hoang Dao Chinh; Le Minh Ky; Vu Truong Phong; Nguyen Kim Luu; Nguyen Thanh Trung; Ho Anh Son; Hoang Van Luong; Nghiem Duc Thuan; Ngo Thanh Tung; Ho Huu Tho
Journal:  Cancer Control       Date:  2020 Jul-Aug       Impact factor: 3.302

6.  Epstein-Barr Virus (EBV) Genotypes Associated with the Immunopathological Profile of People Living with HIV-1: Immunological Aspects of Primary EBV Infection.

Authors:  Leonn Mendes Soares Pereira; Eliane Dos Santos França; Iran Barros Costa; Igor Tenório Lima; Amaury Bentes Cunha Freire; Francisco Lúzio de Paula Ramos; Talita Antonia Furtado Monteiro; Olinda Macedo; Rita Catarina Medeiros Sousa; Felipe Bonfim Freitas; Igor Brasil Costa; Antonio Carlos Rosário Vallinoto
Journal:  Viruses       Date:  2022-01-18       Impact factor: 5.048

7.  Reactivation of EBV and CMV in Severe COVID-19-Epiphenomena or Trigger of Hyperinflammation in Need of Treatment? A Large Case Series of Critically ill Patients.

Authors:  Jan-Hendrik Naendrup; Jorge Garcia Borrega; Dennis Alexander Eichenauer; Alexander Shimabukuro-Vornhagen; Matthias Kochanek; Boris Böll
Journal:  J Intensive Care Med       Date:  2021-11-18       Impact factor: 2.889

Review 8.  Human γ-Herpesvirus Infection, Tumorigenesis, and Immune Control in Mice with Reconstituted Human Immune System Components.

Authors:  Christian Münz
Journal:  Front Immunol       Date:  2018-02-12       Impact factor: 7.561

9.  Sequencing-based counting and size profiling of plasma Epstein-Barr virus DNA enhance population screening of nasopharyngeal carcinoma.

Authors:  W K Jacky Lam; Peiyong Jiang; K C Allen Chan; Suk H Cheng; Haiqiang Zhang; Wenlei Peng; O Y Olivia Tse; Yu K Tong; Wanxia Gai; Benny C Y Zee; Brigette B Y Ma; Edwin P Hui; Anthony T C Chan; John K S Woo; Rossa W K Chiu; Y M Dennis Lo
Journal:  Proc Natl Acad Sci U S A       Date:  2018-05-14       Impact factor: 11.205

10.  High pretreatment plasma Epstein-Barr virus (EBV) DNA level is a poor prognostic marker in HIV-associated, EBV-negative diffuse large B-cell lymphoma in Malawi.

Authors:  Nathan D Montgomery; Cara Randall; Matthew Painschab; Ryan Seguin; Bongani Kaimila; Edwards Kasonkanji; Takondwa Zuze; Robert Krysiak; Marcia K Sanders; Avian Elliott; Melissa B Miller; Coxcilly Kampani; Fred Chimzimu; Maurice Mulenga; Blossom Damania; Tamiwe Tomoka; Yuri Fedoriw; Dirk P Dittmer; Satish Gopal
Journal:  Cancer Med       Date:  2019-11-29       Impact factor: 4.452
  10 in total

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