Justin R Ryder1, Donald R Dengel2, David R Jacobs3, Alan R Sinaiko4, Aaron S Kelly5, Julia Steinberger4. 1. Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN; Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN. Electronic address: jrryder@umn.edu. 2. Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN; School of Kinesiology, University of Minnesota, Minneapolis, MN. 3. Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN. 4. Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN. 5. Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN; Department of Medicine, University of Minnesota Medical School, Minneapolis, MN.
Abstract
OBJECTIVE: To determine the associations of adiposity and insulin resistance with measures of vascular structure and function in children. STUDY DESIGN: A cross-sectional study included 252 children (age 15.1 ± 2.4 years; body mass index percentile 68.2 ± 26.5%; Tanner 2-5). Measurements of body fat percentage were obtained with dual-energy X-ray absorptiometry and visceral adipose tissue (VAT) with computed tomography. Insulin resistance was measured with hyperinsulinemic euglycemic clamp. Vascular measurements for endothelial function (brachial artery flow-mediated dilation [FMD]), vascular structure (carotid intima-media thickness [cIMT]), vascular stiffness (carotid incremental elastic modulus), and pulse wave velocity were analyzed by tertiles of adiposity and insulin resistance. Additional analyses with ANCOVA and linear regression were adjusted for Tanner, sex, race, and family relationship; FMD was also adjusted for baseline artery diameter. RESULTS: FMD was positively associated with high adiposity (body mass index, body fat percentage, and VAT) (P < .01 all). Insulin resistance was not associated with FMD. cIMT was significantly, positively related to obesity, VAT, and insulin resistance (P < .05 all). No differences in carotid incremental elastic modulus and pulse wave velocity were observed in relation to adiposity or insulin resistance. CONCLUSIONS: The findings suggest that adiposity is associated with higher FMD, and insulin resistance and VAT are associated with higher cIMT in children. Further research is needed to clarify the progression of these relations.
OBJECTIVE: To determine the associations of adiposity and insulin resistance with measures of vascular structure and function in children. STUDY DESIGN: A cross-sectional study included 252 children (age 15.1 ± 2.4 years; body mass index percentile 68.2 ± 26.5%; Tanner 2-5). Measurements of body fat percentage were obtained with dual-energy X-ray absorptiometry and visceral adipose tissue (VAT) with computed tomography. Insulin resistance was measured with hyperinsulinemic euglycemic clamp. Vascular measurements for endothelial function (brachial artery flow-mediated dilation [FMD]), vascular structure (carotid intima-media thickness [cIMT]), vascular stiffness (carotid incremental elastic modulus), and pulse wave velocity were analyzed by tertiles of adiposity and insulin resistance. Additional analyses with ANCOVA and linear regression were adjusted for Tanner, sex, race, and family relationship; FMD was also adjusted for baseline artery diameter. RESULTS:FMD was positively associated with high adiposity (body mass index, body fat percentage, and VAT) (P < .01 all). Insulin resistance was not associated with FMD. cIMT was significantly, positively related to obesity, VAT, and insulin resistance (P < .05 all). No differences in carotid incremental elastic modulus and pulse wave velocity were observed in relation to adiposity or insulin resistance. CONCLUSIONS: The findings suggest that adiposity is associated with higher FMD, and insulin resistance and VAT are associated with higher cIMT in children. Further research is needed to clarify the progression of these relations.
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