Yu-Mei Wei1, Hui-Xia Yang1, Wei-Wei Zhu1, Xin-Yue Liu2, Wen-Ying Meng3, Yong-Qing Wang4, Li-Xin Shang5, Zhen-Yu Cai6, Li-Ping Ji7, Yun-Feng Wang8, Ying Sun9, Jia-Xiu Liu10, Li Wei11, Yu-Feng Sun12, Xue-Ying Zhang13, Tian-Xia Luo14, Hai-Xia Chen15, Li-Jun Yu16. 1. a Peking University First Hospital , Beijing , China . 2. b Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida , FL , USA . 3. c Tongzhou Maternal and Child Health Hospital of Beijing , Beijing , China . 4. d Peking University Third Hospital , Beijing , China . 5. e General Hospital of Beijing Military Region , Beijing , China . 6. f Center Hospital of Aviation Industry , Beijing , China . 7. g Pinggu Maternal and Child Health Hospital of Beijing , Beijing , China . 8. h Beijing Hospital of Miyun City , Beijing , China . 9. i Navy General Hospital , Beijing , China . 10. j Beijing Daxing District Hongxing Hospital , Beijing , China . 11. k Beijing Chui Yang Liu Hospital , Beijing , China . 12. l Peking University Shougang Hospital , Beijing , China . 13. m Combined with Traditional Chinese and Western Medicine Hospital of Beijing City , Beijing , China . 14. n Beijing No.6 Hospital , Beijing , China . 15. o Beijing Changping Hospital of Traditional Chinese Medicine , Beijing , China , and. 16. p General Hospital of Jingmei Group , Beijing , China.
Abstract
OBJECTIVE: To estimate the risk of adverse maternal and perinatal outcomes in women with different pre-pregnancy body mass index (BMI). METHODS: We conducted a cohort study with 14 451 singleton pregnancies in 15 medical centers in Beijing between 20 June 2013 and 30 November 2013 using cluster random sampling. We divided participants into four groups based on pre-pregnancy BMI: Group A (underweight): BMI < 18.5 kg/m(2), Group B (normal): 18.5-23.9 kg/m(2), Group C (overweight): 24-27.9 kg/m(2), Group D (obesity): ≥28 kg/m(2). We used multivariate analysis to evaluate the association of the risk of adverse pregnancy outcomes and pre-pregnancy BMI. RESULTS: The prevalence of maternal overweight and obesity was 14.82% (2142/14 451) and 4.71% (680/14 451) in the study population, respectively. Higher pre-pregnancy BMI is associated with higher prevalence of gestational diabetes (GDM), macrosomia, Cesarean section (C-section), preeclampsia and postpartum hemorrhage. Pre-pregnancy overweight or obesity increases the risk of adverse pregnancy outcomes, regardless of GDM status. CONCLUSIONS: Pre-pregnancy overweight or obesity is associated with increased risk of adverse pregnancy outcomes. Nutrition counseling is recommended before pregnancy in women who have overweight or obesity.
OBJECTIVE: To estimate the risk of adverse maternal and perinatal outcomes in women with different pre-pregnancy body mass index (BMI). METHODS: We conducted a cohort study with 14 451 singleton pregnancies in 15 medical centers in Beijing between 20 June 2013 and 30 November 2013 using cluster random sampling. We divided participants into four groups based on pre-pregnancy BMI: Group A (underweight): BMI < 18.5 kg/m(2), Group B (normal): 18.5-23.9 kg/m(2), Group C (overweight): 24-27.9 kg/m(2), Group D (obesity): ≥28 kg/m(2). We used multivariate analysis to evaluate the association of the risk of adverse pregnancy outcomes and pre-pregnancy BMI. RESULTS: The prevalence of maternal overweight and obesity was 14.82% (2142/14 451) and 4.71% (680/14 451) in the study population, respectively. Higher pre-pregnancy BMI is associated with higher prevalence of gestational diabetes (GDM), macrosomia, Cesarean section (C-section), preeclampsia and postpartum hemorrhage. Pre-pregnancy overweight or obesity increases the risk of adverse pregnancy outcomes, regardless of GDM status. CONCLUSIONS: Pre-pregnancy overweight or obesity is associated with increased risk of adverse pregnancy outcomes. Nutrition counseling is recommended before pregnancy in women who have overweight or obesity.
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