Literature DB >> 26424943

A triad of linezolid toxicity: hypoglycemia, lactic acidosis, and acute pancreatitis.

P Connor Johnson1, Muthiah Vaduganathan1, Kristy M Phillips1, Walter J O'Donnell1.   

Abstract

We present a case of suspected linezolid toxicity in a 34-year-old man with sickle cell disease and line-related vancomycin-resistant enterococcal bacteremia and tricuspid valve endocarditis. The patient developed sudden-onset hypoglycemia, lactic acidosis, and acute pancreatitis 11 days after initiation of linezolid. All adverse effects quickly resolved with drug cessation. The pathophysiology underlying this triad of linezolid toxicity is unclear, but may be related to mitochondrial dysfunction.

Entities:  

Year:  2015        PMID： 26424943      PMCID： PMC4569226          DOI： 10.1080/08998280.2015.11929310

Source DB:  PubMed          Journal:  Proc (Bayl Univ Med Cent)        ISSN： 0899-8280


  16 in total

1.  Mitochondrial toxicity associated with linezolid.

Authors:  Alex Soriano; Oscar Miró; Josep Mensa
Journal:  N Engl J Med       Date:  2005-11-24       Impact factor: 91.245

Review 2.  Mitochondrial medicine: a new era in medicine opens new windows and brings new challenges.

Authors:  Evangelos D Michelakis
Journal:  Circulation       Date:  2008-05-13       Impact factor: 29.690

3.  A case of lactic acidosis induced by linezolid.

Authors:  Juan Carlos Q Velez; Michael G Janech
Journal:  Nat Rev Nephrol       Date:  2010-04       Impact factor: 28.314

4.  Reversible inhibition of mitochondrial protein synthesis during linezolid-related hyperlactatemia.

Authors:  Glòria Garrabou; Alejandro Soriano; Sònia López; Jordi P Guallar; Marta Giralt; Francesc Villarroya; Jose A Martínez; Jordi Casademont; Francesc Cardellach; Josep Mensa; Oscar Miró
Journal:  Antimicrob Agents Chemother       Date:  2006-12-28       Impact factor: 5.191

5.  Linezolid and lactic acidosis: a role for lactate monitoring with long-term linezolid use in children.

Authors:  Erik Su; Kelli Crowley; Joseph A Carcillo; Marian G Michaels
Journal:  Pediatr Infect Dis J       Date:  2011-09       Impact factor: 2.129

6.  Linezolid-associated hypoglycemia in a 64-year-old man with type 2 diabetes.

Authors:  Timothy Bodnar; Katelyn Starr; Jeffrey B Halter
Journal:  Am J Geriatr Pharmacother       Date:  2011-02

Review 7.  Vancomycin-resistant enterococcal bacteremia pharmacotherapy.

Authors:  Ruchi Patel; Jason C Gallagher
Journal:  Ann Pharmacother       Date:  2014-10-28       Impact factor: 3.154

8.  Linezolid-containing regimens for the treatment of drug-resistant tuberculosis in South African children.

Authors:  P C Rose; U M Hallbauer; J A Seddon; A C Hesseling; H S Schaaf
Journal:  Int J Tuberc Lung Dis       Date:  2012-10-02       Impact factor: 2.373

9.  Hypoglycemia in patients treated with linezolid.

Authors:  Prabha Viswanathan; Dmitri Iarikov; Ronald Wassel; Alma Davidson; Sumathi Nambiar
Journal:  Clin Infect Dis       Date:  2014-06-25       Impact factor: 9.079

10.  Linezolid for the treatment of multidrug-resistant, gram-positive infections: experience from a compassionate-use program.

Authors:  Mary C Birmingham; Craig R Rayner; Alison K Meagher; Susan M Flavin; Donald H Batts; Jerome J Schentag
Journal:  Clin Infect Dis       Date:  2003-01-03       Impact factor: 9.079
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  6 in total

Review 1.  Clinical Pharmacokinetics and Pharmacodynamics of Oxazolidinones.

Authors:  Claire Roger; Jason A Roberts; Laurent Muller
Journal:  Clin Pharmacokinet       Date:  2018-05       Impact factor: 6.447

2.  Real-Life Frequency of New-Onset Thrombocytopenia during Linezolid Treatment.

Authors:  Nicole Giunio-Zorkin; Glen Brown
Journal:  Can J Hosp Pharm       Date:  2018-04-30

3.  Lactic Acidosis Induced by Linezolid Mimics Symptoms of an Acute Intracranial Bleed: A Case Report and Literature Review.

Authors:  Nichole Suzzanne Zuccarini; Tariq Yousuf; Daniel Wozniczka; Anis Abdul Rauf
Journal:  J Clin Med Res       Date:  2016-08-30

4.  Linezolid-Associated Hypoglycemia.

Authors:  Herman Joseph Johannesmeyer; Suhani Bhakta; Felix Morales
Journal:  Drug Saf Case Rep       Date:  2017-11-09

5.  Linezolid Inhibited Synthesis of ATP in Mitochondria: Based on GC-MS Metabolomics and HPLC Method.

Authors:  Xuemei Ye; Aifang Huang; Xianqin Wang; Congcong Wen; Lufeng Hu; Guanyang Lin
Journal:  Biomed Res Int       Date:  2018-10-16       Impact factor: 3.411

Review 6.  The risk factors of linezolid-induced lactic acidosis: A case report and review.

Authors:  Yiyang Mao; Danping Dai; Haiying Jin; Yangyang Wang
Journal:  Medicine (Baltimore)       Date:  2018-09       Impact factor: 1.817
  6 in total

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