Literature DB >> 26424824

An interesting case of an antihypertensive causing post-prostatectomy incontinence.

Debashis Sarkar1, Manal Kumar2.   

Abstract

A 70-year-old man underwent a laparoscopic radical prostatectomy with preservation of bladder neck for T3aN0R0 prostate cancer in December 2009, (Gleason 4+3, negative surgical margin). His postoperative prostate-specific antigen rose from 0.01 to 0.05 ng/mL over 19 months. He had salvage radiotherapy in May 2012. Following radiotherapy, his urinary control worsened and he needed to wear up to four pads per day. He was being considered for an artificial urinary sphincter placement. He was also taking doxazosin for hypertension, which was discontinued. After stopping the doxazosin, his urinary control improved and he did not require any further intervention. Doctors should be aware of the effect of α-blockers on the internal sphincter and the risk of incontinence in patients post-prostate cancer treatment. 2015 BMJ Publishing Group Ltd.

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Year:  2015        PMID: 26424824      PMCID: PMC4593267          DOI: 10.1136/bcr-2015-211576

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  6 in total

1.  Preservation of the smooth muscular internal (vesical) sphincter and of the proximal urethra during retropubic radical prostatectomy: a technical modification to improve the early recovery of continence.

Authors:  Eugenio Brunocilla; Riccardo Schiavina; Marco Borghesi; Cristian Pultrone; Matteo Cevenini; Valerio Vagnoni; Giuseppe Martorana
Journal:  Arch Ital Urol Androl       Date:  2014-06-30

2.  Alpha-adrenoceptor blocking drugs and female urinary incontinence: prevalence and reversibility.

Authors:  H J Marshall; D G Beevers
Journal:  Br J Clin Pharmacol       Date:  1996-10       Impact factor: 4.335

3.  Stress urinary incontinence due to prescription medications: alpha-blockers and angiotensin converting enzyme inhibitors.

Authors:  S A Menefee; R Chesson; L L Wall
Journal:  Obstet Gynecol       Date:  1998-05       Impact factor: 7.661

4.  Stepwise description and outcomes of bladder neck sparing during robot-assisted laparoscopic radical prostatectomy.

Authors:  David F Friedlander; Mehrdad Alemozaffar; Nathanael D Hevelone; Stuart R Lipsitz; Jim C Hu
Journal:  J Urol       Date:  2012-09-19       Impact factor: 7.450

5.  Impact of complete bladder neck preservation on urinary continence, quality of life and surgical margins after radical prostatectomy: a randomized, controlled, single blind trial.

Authors:  Joanne N Nyarangi-Dix; Jan Philipp Radtke; Boris Hadaschik; Sascha Pahernik; Markus Hohenfellner
Journal:  J Urol       Date:  2012-09-24       Impact factor: 7.450

6.  Laparoscopic radical prostatectomy with bladder neck preservation: positive surgical margin and urinary continence status.

Authors:  Tomasz Golabek; Jaroslaw Jaskulski; Piotr Jarecki; Przemysław Dudek; Tomasz Szopiński; Piotr Chłosta
Journal:  Wideochir Inne Tech Maloinwazyjne       Date:  2014-09-05       Impact factor: 1.195

  6 in total

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