Candida J Rebello1, Jeffrey Burton2, Mark Heiman3, Frank L Greenway4. 1. Pennington Biomedical Research Center, Louisiana State University System, 6400, Perkins Road Baton Rouge, LA 70808, USA; School of Nutrition and Food Sciences, Louisiana State University, Baton Rouge, LA 70803, USA. Electronic address: Candida.Rebello@pbrc.edu. 2. Pennington Biomedical Research Center, Louisiana State University System, 6400, Perkins Road Baton Rouge, LA 70808, USA. Electronic address: Jeff.Burton@pbrc.edu. 3. MicroBiome Therapeutics LLC, 1316 Jefferson Ave., New Orleans, LA 70115, USA. Electronic address: mheiman@mbiome.com. 4. Pennington Biomedical Research Center, Louisiana State University System, 6400, Perkins Road Baton Rouge, LA 70808, USA. Electronic address: Frank.Greenway@pbrc.edu.
Abstract
OBJECTIVE: The objective of this study was to examine the effects of a gastrointestinal microbiome modulator (GIMM) containing inulin, β-glucan, blueberry anthocyanins, and blueberry polyphenols on metabolic parameters, fecal markers of gut microbiota, and satiety. DESIGN AND METHODS: Thirty overweight or obese individuals aged 18 to 70years, were enrolled in a randomized controlled trial. Participants consumed the test product or placebo daily for four weeks. Stool samples were collected and blood was drawn at baseline and week four for assessments of gut microbiota, satiety hormones, glucose control, and lipid measures. Subjective satiety was assessed weekly. Linear models were used to compare differences from baseline to week four. RESULTS: GIMM consumption improved blood glucose tolerance (p=0.008), and increased satiety (p=0.03). There were no statistically significant differences in insulin sensitivity, fecal markers of gut microbiota, plasma satiety hormones, or serum lipid concentrations between the groups. However, plasma satiety hormones and fecal short chain fatty acid concentrations increased in the test group compared to the placebo. CONCLUSIONS: GIMM consumption for four weeks, increases satiety, and improves glucose tolerance possibly through insulin-independent pathways.
RCT Entities:
OBJECTIVE: The objective of this study was to examine the effects of a gastrointestinal microbiome modulator (GIMM) containing inulin, β-glucan, blueberry anthocyanins, and blueberry polyphenols on metabolic parameters, fecal markers of gut microbiota, and satiety. DESIGN AND METHODS: Thirty overweight or obese individuals aged 18 to 70years, were enrolled in a randomized controlled trial. Participants consumed the test product or placebo daily for four weeks. Stool samples were collected and blood was drawn at baseline and week four for assessments of gut microbiota, satiety hormones, glucose control, and lipid measures. Subjective satiety was assessed weekly. Linear models were used to compare differences from baseline to week four. RESULTS: GIMM consumption improved blood glucose tolerance (p=0.008), and increased satiety (p=0.03). There were no statistically significant differences in insulin sensitivity, fecal markers of gut microbiota, plasma satiety hormones, or serum lipid concentrations between the groups. However, plasma satiety hormones and fecal short chain fatty acid concentrations increased in the test group compared to the placebo. CONCLUSIONS: GIMM consumption for four weeks, increases satiety, and improves glucose tolerance possibly through insulin-independent pathways.
Authors: Kristiina R Juvonen; Anna-Kaisa Purhonen; Marjatta Salmenkallio-Marttila; Liisa Lähteenmäki; David E Laaksonen; Karl-Heinz Herzig; Matti I J Uusitupa; Kaisa S Poutanen; Leila J Karhunen Journal: J Nutr Date: 2009-01-28 Impact factor: 4.798
Authors: Tri Vuong; Louis C Martineau; Charles Ramassamy; Chantal Matar; Pierre S Haddad Journal: Can J Physiol Pharmacol Date: 2007-09 Impact factor: 2.273
Authors: Eleanor J Beck; Susan M Tosh; Marijka J Batterham; Linda C Tapsell; Xu-Feng Huang Journal: Mol Nutr Food Res Date: 2009-10 Impact factor: 5.914
Authors: Rachel L Batterham; Mark A Cohen; Sandra M Ellis; Carel W Le Roux; Dominic J Withers; Gary S Frost; Mohammad A Ghatei; Stephen R Bloom Journal: N Engl J Med Date: 2003-09-04 Impact factor: 91.245
Authors: Gary D Wu; Jun Chen; Christian Hoffmann; Kyle Bittinger; Ying-Yu Chen; Sue A Keilbaugh; Meenakshi Bewtra; Dan Knights; William A Walters; Rob Knight; Rohini Sinha; Erin Gilroy; Kernika Gupta; Robert Baldassano; Lisa Nessel; Hongzhe Li; Frederic D Bushman; James D Lewis Journal: Science Date: 2011-09-01 Impact factor: 47.728
Authors: Angelo Maria Patti; Khalid Al-Rasadi; Rosaria Vincenza Giglio; Dragana Nikolic; Carlo Mannina; Giuseppa Castellino; Roberta Chianetta; Maciej Banach; Arrigo F G Cicero; Giuseppe Lippi; Giuseppe Montalto; Manfredi Rizzo; Peter P Toth Journal: Arch Med Sci Date: 2017-07-19 Impact factor: 3.318