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Literature DB >> 26422835

Patient-derived orthotopic xenografts: better mimic of metastasis than subcutaneous xenografts.

Abstract

The majority of human solid tumours do not metastasize when grown subcutaneously in immunocompromised mice; this includes patient-derived xenograft (PDX) models. However, orthotopic implantation of intact tumour tissue can lead to metastasis that mimics that seen in patients. These patient-derived orthotopic xenograft (PDOX) models have a long history and might better recapitulate human tumours than PDX models.

Entities: Disease Species

Mesh：

Year: 2015 PMID： 26422835 DOI： 10.1038/nrc3972

Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716

17 in total

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Authors: Yukihiko Hiroshima; Yong Zhang; Nan Zhang; Ali Maawy; Sumiyuki Mii; Mako Yamamoto; Fuminari Uehara; Shinji Miwa; Shuya Yano; Takashi Murakami; Masashi Momiyama; Takashi Chishima; Kuniya Tanaka; Yasushi Ichikawa; Michael Bouvet; Takuya Murata; Itaru Endo; Robert M Hoffman
Journal: PLoS One Date: 2015-02-17 Impact factor: 3.240

189 in total

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Authors: Ken Kageyama; Shinji Ozaki; Takami Sato
Journal: J Vis Exp Date: 2019-11-06 Impact factor: 1.355

2. Preclinical Models for Studying the Impact of Macrophages on Cancer Cachexia.

Authors: Spas Dimitrov Markov; Daisy Gonzalez; Kamiya Mehla
Journal: Curr Protoc Pharmacol Date: 2020-12

3. Near Infrared Photoimmunotherapy in a Transgenic Mouse Model of Spontaneous Epidermal Growth Factor Receptor (EGFR)-expressing Lung Cancer.

Authors: Yuko Nakamura; Zoe Weaver Ohler; Deborah Householder; Tadanobu Nagaya; Kazuhide Sato; Shuhei Okuyama; Fusa Ogata; Dagane Daar; Tieu Hoa; Peter L Choyke; Hisataka Kobayashi
Journal: Mol Cancer Ther Date: 2016-11-15 Impact factor: 6.261

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Authors: Yohei Hisada; Nigel Mackman
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Authors: Tadanobu Nagaya; Yuko Nakamura; Kazuhide Sato; Toshiko Harada; Peter L Choyke; Hisataka Kobayashi
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Authors: Zhao-Yang Yin; Si-Yong Qi; Xiang Cheng; Liang Guo; Hong-Yu Chen; Ming Shi
Journal: Nan Fang Yi Ke Da Xue Xue Bao Date: 2017-07-20

7. Locally Trapping the C-C Chemokine Receptor Type 7 by Gene Delivery Nanoparticle Inhibits Lymphatic Metastasis Prior to Tumor Resection.

Authors: Sai An; Karthik Tiruthani; Ying Wang; Ligeng Xu; Mengying Hu; Jingjing Li; Wantong Song; Hongnan Jiang; Jirui Sun; Rihe Liu; Leaf Huang
Journal: Small Date: 2019-01-28 Impact factor: 13.281