Literature DB >> 8517640

Human ovarian carcinoma metastatic models constructed in nude mice by orthotopic transplantation of histologically-intact patient specimens.

X Fu1, R M Hoffman.   

Abstract

We report here the first orthotopic transplant model for human ovarian cancer. Histologically-intact patient specimens of ovarian cancer were transplanted by microsurgical techniques under the capsule of the nude mouse ovary. The human tumors grew locally and gave rise to a patient-like metastatic pattern including the parietal peritoneum, colon, omentum, and ascites. The orthotopic model described here should be useful for evaluating new therapeutics and diagnostics for ovarian cancer.

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Mesh：

Year:  1993        PMID： 8517640

Source DB:  PubMed          Journal:  Anticancer Res        ISSN： 0250-7005            Impact factor:   2.480


  75 in total

1.  Multi-organ metastatic capability of Chinese hamster ovary cells revealed by green fluorescent protein (GFP) expression.

Authors:  M Yang; T Chishima; X Wang; E Baranov; H Shimada; A R Moossa; R M Hoffman
Journal:  Clin Exp Metastasis       Date:  1999-07       Impact factor: 5.150

2.  Metastatic models of human liver cancer in nude mice orthotopically constructed by using histologically intact patient specimens.

Authors:  F X Sun; Z Y Tang; K D Liu; Q Xue; D M Gao; Y Q Yu; X D Zhou; Z C Ma
Journal:  J Cancer Res Clin Oncol       Date:  1996       Impact factor: 4.553

Review 3.  Epithelial ovarian cancer experimental models.

Authors:  E Lengyel; J E Burdette; H A Kenny; D Matei; J Pilrose; P Haluska; K P Nephew; D B Hales; M S Stack
Journal:  Oncogene       Date:  2013-08-12       Impact factor: 9.867

4.  Targeting altered cancer methionine metabolism with recombinant methioninase (rMETase) overcomes partial gemcitabine-resistance and regresses a patient-derived orthotopic xenograft (PDOX) nude mouse model of pancreatic cancer.

Authors:  Kei Kawaguchi; Kentaro Miyake; Qinghong Han; Shukuan Li; Yuying Tan; Kentaro Igarashi; Thinzar M Lwin; Takashi Higuchi; Tasuku Kiyuna; Masuyo Miyake; Hiromichi Oshiro; Michael Bouvet; Michiaki Unno; Robert M Hoffman
Journal:  Cell Cycle       Date:  2018-05-21       Impact factor: 4.534

5.  Targeting methionine with oral recombinant methioninase (o-rMETase) arrests a patient-derived orthotopic xenograft (PDOX) model of BRAF-V600E mutant melanoma: implications for chronic clinical cancer therapy and prevention.

Authors:  Kei Kawaguchi; Qinghong Han; Shukuan Li; Yuying Tan; Kentaro Igarashi; Tasuku Kiyuna; Kentaro Miyake; Masuyo Miyake; Bartosz Chmielowski; Scott D Nelson; Tara A Russell; Sarah M Dry; Yunfeng Li; Arun S Singh; Mark A Eckardt; Michiaki Unno; Fritz C Eilber; Robert M Hoffman
Journal:  Cell Cycle       Date:  2018-03-19       Impact factor: 4.534

6.  Cervical Cancer Patient-Derived Orthotopic Xenograft (PDOX) Is Sensitive to Cisplatinum and Resistant to Nab-paclitaxel.

Authors:  Takashi Murakami; Takuya Murata; Kei Kawaguchi; Tasuku Kiyuna; Kentaro Igarashi; Ho Kyoung Hwang; Yukihiko Hiroshima; Chihiro Hozumi; Shin Komatsu; Takashi Kikuchi; Thinzar M Lwin; Jonathan C Delong; Kentaro Miyake; Yong Zhang; Kuniya Tanaka; Michael Bouvet; Itaru Endo; Robert M Hoffman
Journal:  Anticancer Res       Date:  2017-01       Impact factor: 2.480

7.  Combination of gemcitabine and docetaxel regresses both gastric leiomyosarcoma proliferation and invasion in an imageable patient-derived orthotopic xenograft (iPDOX) model.

Authors:  Kei Kawaguchi; Kentaro Igarashi; Takashi Murakami; Tasuku Kiyuna; Scott D Nelson; Sarah M Dry; Yunfeng Li; Tara A Russell; Arun S Singh; Bartosz Chmielowski; Michiaki Unno; Fritz C Eilber; Robert M Hoffman
Journal:  Cell Cycle       Date:  2017-04-20       Impact factor: 4.534

8.  An ultra-metastatic model of human colon cancer in nude mice.

Authors:  F X Sun; A R Sasson; P Jiang; Z An; R Gamagami; L Li; A R Moossa; R M Hoffman
Journal:  Clin Exp Metastasis       Date:  1999-02       Impact factor: 5.150

9.  Tumor-targeting Salmonella typhimurium A1-R combined with recombinant methioninase and cisplatinum eradicates an osteosarcoma cisplatinum-resistant lung metastasis in a patient-derived orthotopic xenograft (PDOX) mouse model: decoy, trap and kill chemotherapy moves toward the clinic.

Authors:  Kentaro Igarashi; Kei Kawaguchi; Tasuku Kiyuna; Kentaro Miyake; Masuyo Miyake; Shukuan Li; Qinghong Han; Yuying Tan; Ming Zhao; Yunfeng Li; Scott D Nelson; Sarah M Dry; Arun S Singh; Irmina A Elliott; Tara A Russell; Mark A Eckardt; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Hiroyuki Tsuchiya; Fritz C Eilber; Robert M Hoffman
Journal:  Cell Cycle       Date:  2018-04-10       Impact factor: 4.534

10.  A reproducible brain tumour model established from human glioblastoma biopsies.

Authors:  Jian Wang; Hrvoje Miletic; Per Ø Sakariassen; Peter C Huszthy; Hege Jacobsen; Narve Brekkå; Xingang Li; Peng Zhao; Sverre Mørk; Martha Chekenya; Rolf Bjerkvig; Per Ø Enger
Journal:  BMC Cancer       Date:  2009-12-29       Impact factor: 4.430
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