Literature DB >> 26421741

Small Molecules in the Cone Snail Arsenal.

Jorge L B Neves1, Zhenjian Lin, Julita S Imperial, Agostinho Antunes1, Vitor Vasconcelos1, Baldomero M Olivera, Eric W Schmidt.   

Abstract

Cone snails are renowned for producing peptide-based venom, containing conopeptides and conotoxins, to capture their prey. A novel small-molecule guanine derivative with unprecedented features, genuanine, was isolated from the venom of two cone snail species. Genuanine causes paralysis in mice, indicating that small molecules and not just polypeptides may contribute to the activity of cone snail venom.

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Year:  2015        PMID： 26421741      PMCID： PMC4845746          DOI： 10.1021/acs.orglett.5b02389

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  16 in total

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4.  A molluscivorous Conus toxin: conserved frameworks in conotoxins.

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Journal:  Biochemistry       Date:  1989-01-10       Impact factor: 3.162

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7.  Novel excitatory Conus peptides define a new conotoxin superfamily.

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Journal:  J Comp Physiol A Neuroethol Sens Neural Behav Physiol       Date:  2017-05-27       Impact factor: 1.836

2.  Stenotrophomonas-Like Bacteria Are Widespread Symbionts in Cone Snail Venom Ducts.

Authors:  Joshua P Torres; Maria Diarey Tianero; Jose Miguel D Robes; Jason C Kwan; Jason S Biggs; Gisela P Concepcion; Baldomero M Olivera; Margo G Haygood; Eric W Schmidt
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Review 3.  Marine Alkylpurines: A Promising Group of Bioactive Marine Natural Products.

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4.  Three New Cytotoxic Steroidal Glycosides Isolated from Conus pulicarius Collected in Kosrae, Micronesia.

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Review 7.  Curses or Cures: A Review of the Numerous Benefits Versus the Biosecurity Concerns of Conotoxin Research.

Authors:  Walden E Bjørn-Yoshimoto; Iris Bea L Ramiro; Mark Yandell; J Michael McIntosh; Baldomero M Olivera; Lars Ellgaard; Helena Safavi-Hemami
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8.  Small-molecule mimicry hunting strategy in the imperial cone snail, Conus imperialis.

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9.  Small Packages, Big Returns: Uncovering the Venom Diversity of Small Invertebrate Conoidean Snails.

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Review 10.  Non-Peptidic Small Molecule Components from Cone Snail Venoms.

Authors:  Zhenjian Lin; Joshua P Torres; Maren Watkins; Noemi Paguigan; Changshan Niu; Julita S Imperial; Jortan Tun; Helena Safavi-Hemami; Rocio K Finol-Urdaneta; Jorge L B Neves; Samuel Espino; Manju Karthikeyan; Baldomero M Olivera; Eric W Schmidt
Journal:  Front Pharmacol       Date:  2021-05-13       Impact factor: 5.810
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