Literature DB >> 26420304

Metabolomics in childhood diabetes.

Brigitte I Frohnert1, Marian J Rewers1.   

Abstract

Recent increases in the incidence of both type 1 (T1D) and type 2 diabetes (T2D) in children and adolescents point to the importance of environmental factors in the development of these diseases. Metabolomic analysis explores the integrated response of the organism to environmental changes. Metabolic profiling can identify biomarkers that are predictive of disease incidence and development, potentially providing insight into disease pathogenesis. This review provides an overview of the role of metabolomic analysis in diabetes research and summarizes recent research relating to the development of T1D and T2D in children.
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  autoimmunity; diabetes; lipidomics; metabolomics

Mesh：

Substances：

Year:  2015        PMID： 26420304      PMCID： PMC4703499          DOI： 10.1111/pedi.12323

Source DB:  PubMed          Journal:  Pediatr Diabetes        ISSN： 1399-543X            Impact factor:   4.866


  86 in total

1.  Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes.

Authors:  Valeriya Lyssenko; Peter Almgren; Dragi Anevski; Roland Perfekt; Kaj Lahti; Michael Nissén; Bo Isomaa; Björn Forsen; Nils Homström; Carola Saloranta; Marja-Riitta Taskinen; Leif Groop; Tiinamaija Tuomi
Journal:  Diabetes       Date:  2005-01       Impact factor: 9.461

Review 2.  Analytical approaches to metabolomics and applications to systems biology.

Authors:  Jeffrey H Wang; Jaeman Byun; Subramaniam Pennathur
Journal:  Semin Nephrol       Date:  2010-09       Impact factor: 5.299

Review 3.  Molecular mechanisms in autoimmune type 1 diabetes: a critical review.

Authors:  Zhiguo Xie; Christopher Chang; Zhiguang Zhou
Journal:  Clin Rev Allergy Immunol       Date:  2014-10       Impact factor: 8.667

Review 4.  Metabolic profiling in diabetes.

Authors:  Karsten Suhre
Journal:  J Endocrinol       Date:  2014-06       Impact factor: 4.286

5.  Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women.

Authors:  Sean H Adams; Charles L Hoppel; Kerry H Lok; Ling Zhao; Scott W Wong; Paul E Minkler; Daniel H Hwang; John W Newman; W Timothy Garvey
Journal:  J Nutr       Date:  2009-04-15       Impact factor: 4.798

6.  Early metabolic markers of the development of dysglycemia and type 2 diabetes and their physiological significance.

Authors:  Ele Ferrannini; Andrea Natali; Stefania Camastra; Monica Nannipieri; Andrea Mari; Klaus-Peter Adam; Michael V Milburn; Gabi Kastenmüller; Jerzy Adamski; Tiinamaija Tuomi; Valeriya Lyssenko; Leif Groop; Walter E Gall
Journal:  Diabetes       Date:  2012-11-16       Impact factor: 9.461

7.  Metabolic regulation in progression to autoimmune diabetes.

Authors:  Marko Sysi-Aho; Andrey Ermolov; Peddinti V Gopalacharyulu; Abhishek Tripathi; Tuulikki Seppänen-Laakso; Johanna Maukonen; Ismo Mattila; Suvi T Ruohonen; Laura Vähätalo; Laxman Yetukuri; Taina Härkönen; Erno Lindfors; Janne Nikkilä; Jorma Ilonen; Olli Simell; Maria Saarela; Mikael Knip; Samuel Kaski; Eriika Savontaus; Matej Orešič
Journal:  PLoS Comput Biol       Date:  2011-10-27       Impact factor: 4.475

8.  Innate immunity and intestinal microbiota in the development of Type 1 diabetes.

Authors:  Li Wen; Ruth E Ley; Pavel Yu Volchkov; Peter B Stranges; Lia Avanesyan; Austin C Stonebraker; Changyun Hu; F Susan Wong; Gregory L Szot; Jeffrey A Bluestone; Jeffrey I Gordon; Alexander V Chervonsky
Journal:  Nature       Date:  2008-09-21       Impact factor: 49.962

9.  Branched-chain and aromatic amino acids are predictors of insulin resistance in young adults.

Authors:  Peter Würtz; Pasi Soininen; Antti J Kangas; Tapani Rönnemaa; Terho Lehtimäki; Mika Kähönen; Jorma S Viikari; Olli T Raitakari; Mika Ala-Korpela
Journal:  Diabetes Care       Date:  2012-11-05       Impact factor: 19.112

10.  Cord serum lipidome in prediction of islet autoimmunity and type 1 diabetes.

Authors:  Matej Oresic; Peddinti Gopalacharyulu; Juha Mykkänen; Niina Lietzen; Marjaana Mäkinen; Heli Nygren; Satu Simell; Ville Simell; Heikki Hyöty; Riitta Veijola; Jorma Ilonen; Marko Sysi-Aho; Mikael Knip; Tuulia Hyötyläinen; Olli Simell
Journal:  Diabetes       Date:  2013-04-29       Impact factor: 9.461
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  17 in total

Review 1.  Metabolomics and Metabolic Diseases: Where Do We Stand?

Authors:  Christopher B Newgard
Journal:  Cell Metab       Date:  2016-10-27       Impact factor: 27.287

2.  Metabolomics allows the discrimination of the pathophysiological relevance of hyperinsulinism in obese prepubertal children.

Authors:  G Á Martos-Moreno; A Mastrangelo; V Barrios; A García; J A Chowen; F J Rupérez; C Barbas; J Argente
Journal:  Int J Obes (Lond)       Date:  2017-06-07       Impact factor: 5.095

Review 3.  Lipidomics: Techniques, Applications, and Outcomes Related to Biomedical Sciences.

Authors:  Kui Yang; Xianlin Han
Journal:  Trends Biochem Sci       Date:  2016-09-20       Impact factor: 13.807

Review 4.  Understanding childhood diabetes mellitus: new pathophysiological aspects.

Authors:  Juergen Grulich-Henn; Daniela Klose
Journal:  J Inherit Metab Dis       Date:  2017-12-15       Impact factor: 4.982

5.  Phospholipid Levels at Seroconversion Are Associated With Resolution of Persistent Islet Autoimmunity: The Diabetes Autoimmunity Study in the Young.

Authors:  Patrick M Carry; Lauren A Vanderlinden; Randi K Johnson; Teresa Buckner; Oliver Fiehn; Andrea K Steck; Katerina Kechris; Ivana Yang; Tasha E Fingerlin; Marian Rewers; Jill M Norris
Journal:  Diabetes       Date:  2021-04-16       Impact factor: 9.337

6.  An individual participant data meta-analysis on metabolomics profiles for obesity and insulin resistance in European children.

Authors:  Christian Hellmuth; Franca F Kirchberg; Stephanie Brandt; Anja Moß; Viola Walter; Dietrich Rothenbacher; Hermann Brenner; Veit Grote; Dariusz Gruszfeld; Piotr Socha; Ricardo Closa-Monasterolo; Joaquin Escribano; Veronica Luque; Elvira Verduci; Benedetta Mariani; Jean-Paul Langhendries; Pascale Poncelet; Joachim Heinrich; Irina Lehmann; Marie Standl; Olaf Uhl; Berthold Koletzko; Elisabeth Thiering; Martin Wabitsch
Journal:  Sci Rep       Date:  2019-03-25       Impact factor: 4.379

7.  Feasibility of Localized Metabolomics in the Study of Pancreatic Islets and Diabetes.

Authors:  Oscar Alcazar; Luis F Hernandez; Ashley Tschiggfrie; Michael J Muehlbauer; James R Bain; Peter Buchwald; Midhat H Abdulreda
Journal:  Metabolites       Date:  2019-09-29

8.  Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study.

Authors:  Qian Li; Hemang Parikh; Martha D Butterworth; Åke Lernmark; William Hagopian; Marian Rewers; Jin-Xiong She; Jorma Toppari; Anette-G Ziegler; Beena Akolkar; Oliver Fiehn; Sili Fan; Jeffrey P Krischer
Journal:  Diabetes       Date:  2020-02-06       Impact factor: 9.337

9.  Relation of Whole Blood Amino Acid and Acylcarnitine Metabolome to Age, Sex, BMI, Puberty, and Metabolic Markers in Children and Adolescents.

Authors:  Josephin Hirschel; Mandy Vogel; Ronny Baber; Antje Garten; Carl Beuchel; Yvonne Dietz; Julia Dittrich; Antje Körner; Wieland Kiess; Uta Ceglarek
Journal:  Metabolites       Date:  2020-04-10

10.  Impact of lifestyle Intervention on branched-chain amino acid catabolism and insulin sensitivity in adolescents with obesity.

Authors:  Catherine Jachthuber Trub; Metin Balikcioglu; Michael Freemark; James Bain; Michael Muehlbauer; Olga Ilkayeva; Phillip J White; Sarah Armstrong; Truls Østbye; Steven Grambow; Pinar Gumus Balikcioglu
Journal:  Endocrinol Diabetes Metab       Date:  2021-04-01
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