Kanae Nishizaki1, Hitoshi Ikegami2, Yukio Tanaka3, Ryutaro Imai4, Hajime Matsumura5. 1. Department of Rehabilitation, Kugawa Hospital for Orthopaedic Surgery, Yamanashi, Japan. 2. Department of Orthopaedic Surgery, Kugawa Hospital for Orthopaedic Surgery, Yamanashi, Japan. 3. Department of Anesthesiology, Kugawa Hospital for Orthopaedic Surgery, Yamanashi, Japan. 4. Department of Plastic and Reconstructive Surgery, Tokyo Medical University, Tokyo, Japan. 5. Department of Plastic and Reconstructive Surgery, Tokyo Medical University, Tokyo, Japan. Email: hmatsu-tki@umin.ac.jp.
Abstract
OBJECTIVES:Total knee arthroplasty (TKA) performed in knee osteoarthritis patients is reported to be immediately followed by a decrease in quadriceps muscle strength. We investigated the effects of supplementation with a combination β-hydroxy-β-methyl butyrate, L-arginine, and L-glutamine (HMB/Arg/Gln) on the postoperative recovery of quadriceps muscle strength in patients after TKA. METHODS:Study subjects were 23 patients (12 women; mean age: 70.5) who underwent TKA. The patients were randomly allocated into the control group or the group that consumed HMB/Arg/Gln supplementation (HMB/Arg/Gln group). HMB/Arg/Gln supplementation or control food were consumed for 5 days before the surgery and for 28 days after the surgery, and maximal quadriceps strength was measured at 7 days before the surgery, and at 14, 28 and 42 days after the surgery. During the study, total energy expenditure was measured using a lifestyle recording device. The two groups followed the rehabilitation in the same way. RESULTS: The maximal quadriceps strength was 1.1±0.62 Nm/Kg before surgery and 0.7±0.9 Nm/Kg after surgery 14 days in the control group (p=0.02), and 1.1±0.3 Nm/Kg before surgery and 0.9±0.4 Nm/Kg after surgery 14 days in the HMB/Arg/Gln group. Although the control group experienced a significant loss of muscle strength after the surgery, the HMB/Arg/Gln group did not. There was no significant difference in total energy expenditure between the two groups. CONCLUSIONS: Consuming HMB/Arg/Gln supplementation may suppress the loss of muscle strength after TKA. Intervention with exercise and nutrition appears to enable patients to maintain their quadriceps strength.
RCT Entities:
OBJECTIVES:Total knee arthroplasty (TKA) performed in knee osteoarthritispatients is reported to be immediately followed by a decrease in quadriceps muscle strength. We investigated the effects of supplementation with a combination β-hydroxy-β-methyl butyrate, L-arginine, and L-glutamine (HMB/Arg/Gln) on the postoperative recovery of quadriceps muscle strength in patients after TKA. METHODS: Study subjects were 23 patients (12 women; mean age: 70.5) who underwent TKA. The patients were randomly allocated into the control group or the group that consumed HMB/Arg/Gln supplementation (HMB/Arg/Gln group). HMB/Arg/Gln supplementation or control food were consumed for 5 days before the surgery and for 28 days after the surgery, and maximal quadriceps strength was measured at 7 days before the surgery, and at 14, 28 and 42 days after the surgery. During the study, total energy expenditure was measured using a lifestyle recording device. The two groups followed the rehabilitation in the same way. RESULTS: The maximal quadriceps strength was 1.1±0.62 Nm/Kg before surgery and 0.7±0.9 Nm/Kg after surgery 14 days in the control group (p=0.02), and 1.1±0.3 Nm/Kg before surgery and 0.9±0.4 Nm/Kg after surgery 14 days in the HMB/Arg/Gln group. Although the control group experienced a significant loss of muscle strength after the surgery, the HMB/Arg/Gln group did not. There was no significant difference in total energy expenditure between the two groups. CONCLUSIONS: Consuming HMB/Arg/Gln supplementation may suppress the loss of muscle strength after TKA. Intervention with exercise and nutrition appears to enable patients to maintain their quadriceps strength.
Authors: A Sanz-Paris; M Camprubi-Robles; J M Lopez-Pedrosa; S L Pereira; R Rueda; M D Ballesteros-Pomar; J M Garcia Almeida; A J Cruz-Jentoft Journal: J Nutr Health Aging Date: 2018 Impact factor: 4.075
Authors: Patrick B Collins; Conrad P Earnest; Ryan L Dalton; Ryan J Sowinski; Tyler J Grubic; Christopher J Favot; Adriana M Coletta; Christopher Rasmussen; Mike Greenwood; Richard B Kreider Journal: Nutrients Date: 2017-08-01 Impact factor: 5.717