Boyoon Choi1, Myeong Gyu Kim1, Nayoung Han1, Therasa Kim2, Eunhee Ji3, Seonyang Park4, In-Wha Kim1, Jung Mi Oh1. 1. College of Pharmacy & Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea. 2. College of Pharmacy, Chonnam National University, Gwangju, Korea. 3. College of Pharmacy, Gachon University, Incheon, Korea. 4. Department of Internal Medicine, Seoul National University Medicine of College, Seoul, Korea.
Abstract
AIM: A population pharmacokinetic (PPK) analysis was conducted to describe the influence of GSTA1 polymorphisms on intravenous busulfan in adults undergoing allogeneic hematopoietic stem cell transplantation. PATIENTS & METHODS: A PPK model was developed from 36 patients by a one-compartment model with first-order elimination. RESULTS: The typical value of clearance and volume of distribution were 11.0 l/h and 42.4 l, respectively. Clearance decreased by 15% and area under the concentration-time curves (AUCs) increased with GSTA1 variants compared with wild-type (both p < 0.05). Subtherapeutic AUCs were seen only in wild-type patients. CONCLUSION: To our knowledge, this is the first PPK study to suggest that GSTA1 polymorphisms in adults are associated with busulfan PK.
AIM: A population pharmacokinetic (PPK) analysis was conducted to describe the influence of GSTA1 polymorphisms on intravenous busulfan in adults undergoing allogeneic hematopoietic stem cell transplantation. PATIENTS & METHODS: A PPK model was developed from 36 patients by a one-compartment model with first-order elimination. RESULTS: The typical value of clearance and volume of distribution were 11.0 l/h and 42.4 l, respectively. Clearance decreased by 15% and area under the concentration-time curves (AUCs) increased with GSTA1 variants compared with wild-type (both p < 0.05). Subtherapeutic AUCs were seen only in wild-type patients. CONCLUSION: To our knowledge, this is the first PPK study to suggest that GSTA1 polymorphisms in adults are associated with busulfan PK.
Authors: Adrin Dadkhah; Sebastian Georg Wicha; Nicolaus Kröger; Alexander Müller; Christoph Pfaffendorf; Maria Riedner; Anita Badbaran; Boris Fehse; Claudia Langebrake Journal: Pharmaceutics Date: 2022-05-27 Impact factor: 6.525
Authors: Marc Ansari; Patricia Huezo-Diaz Curtis; Chakradhara Rao S Uppugunduri; Mohammed Aziz Rezgui; Tiago Nava; Vid Mlakar; Laurence Lesne; Yves Théoret; Yves Chalandon; Lee L Dupuis; Tao Schechter; Imke H Bartelink; Jaap J Boelens; Robbert Bredius; Jean-Hugues Dalle; Saba Azarnoush; Petr Sedlacek; Victor Lewis; Martin Champagne; Christina Peters; Henrique Bittencourt; Maja Krajinovic Journal: Oncotarget Date: 2017-08-27
Authors: Veronique Michaud; My Tran; Benoit Pronovost; Philippe Bouchard; Sarah Bilodeau; Karine Alain; Barbara Vadnais; Martin Franco; François Bélanger; Jacques Turgeon Journal: Pharmaceutics Date: 2019-09-01 Impact factor: 6.321
Authors: Adrin Dadkhah; Dzenefa Alihodzic; Astrid Broeker; Nicolaus Kröger; Claudia Langebrake; Sebastian G Wicha Journal: Pharm Res Date: 2021-10-18 Impact factor: 4.200
Authors: Jurgen B Langenhorst; Jill Boss; Charlotte van Kesteren; Arief Lalmohamed; Jürgen Kuball; Antoine C G Egberts; Jaap Jan Boelens; Alwin D R Huitema; Erik M van Maarseveen Journal: Br J Clin Pharmacol Date: 2020-03-10 Impact factor: 4.335