Literature DB >> 26416678

Present and future challenges of induced pluripotent stem cells.

Mari Ohnuki1, Kazutoshi Takahashi2.   

Abstract

Growing old is our destiny. However, the mature differentiated cells making up our body can be rejuvenated to an embryo-like fate called pluripotency which is an ability to differentiate into all cell types by enforced expression of defined transcription factors. The discovery of this induced pluripotent stem cell (iPSC) technology has opened up unprecedented opportunities in regenerative medicine, disease modelling and drug discovery. In this review, we introduce the applications and future perspectives of human iPSCs and we also show how iPSC technology has evolved along the way.
© 2015 The Author(s).

Entities:  

Keywords:  cancer; epigenetics; induced pluripotent stem cells; regenerative medicine; reprogramming

Mesh：

Year:  2015        PMID： 26416678      PMCID： PMC4633996          DOI： 10.1098/rstb.2014.0367

Source DB:  PubMed          Journal:  Philos Trans R Soc Lond B Biol Sci        ISSN： 0962-8436            Impact factor:   6.237


  118 in total

1.  Comparable frequencies of coding mutations and loss of imprinting in human pluripotent cells derived by nuclear transfer and defined factors.

Authors:  Bjarki Johannesson; Ido Sagi; Athurva Gore; Daniel Paull; Mitsutoshi Yamada; Tamar Golan-Lev; Zhe Li; Charles LeDuc; Yufeng Shen; Samantha Stern; Nanfang Xu; Hong Ma; Eunju Kang; Shoukhrat Mitalipov; Mark V Sauer; Kun Zhang; Nissim Benvenisty; Dieter Egli
Journal:  Cell Stem Cell       Date:  2014-11-06       Impact factor: 24.633

2.  Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming.

Authors:  Clifford D L Folmes; Timothy J Nelson; Almudena Martinez-Fernandez; D Kent Arrell; Jelena Zlatkovic Lindor; Petras P Dzeja; Yasuhiro Ikeda; Carmen Perez-Terzic; Andre Terzic
Journal:  Cell Metab       Date:  2011-08-03       Impact factor: 27.287

3.  Suppression of induced pluripotent stem cell generation by the p53-p21 pathway.

Authors:  Hyenjong Hong; Kazutoshi Takahashi; Tomoko Ichisaka; Takashi Aoi; Osami Kanagawa; Masato Nakagawa; Keisuke Okita; Shinya Yamanaka
Journal:  Nature       Date:  2009-08-09       Impact factor: 49.962

4.  Dynamic suspension culture for scalable expansion of undifferentiated human pluripotent stem cells.

Authors:  Michal Amit; Ilana Laevsky; Yael Miropolsky; Kohava Shariki; Meital Peri; Joseph Itskovitz-Eldor
Journal:  Nat Protoc       Date:  2011-04-07       Impact factor: 13.491

5.  Reprogramming of human somatic cells to pluripotency with defined factors.

Authors:  In-Hyun Park; Rui Zhao; Jason A West; Akiko Yabuuchi; Hongguang Huo; Tan A Ince; Paul H Lerou; M William Lensch; George Q Daley
Journal:  Nature       Date:  2007-12-23       Impact factor: 49.962

6.  iPS cells produce viable mice through tetraploid complementation.

Authors:  Xiao-yang Zhao; Wei Li; Zhuo Lv; Lei Liu; Man Tong; Tang Hai; Jie Hao; Chang-long Guo; Qing-wen Ma; Liu Wang; Fanyi Zeng; Qi Zhou
Journal:  Nature       Date:  2009-09-03       Impact factor: 49.962

7.  Derivation of naive human embryonic stem cells.

Authors:  Carol B Ware; Angelique M Nelson; Brigham Mecham; Jennifer Hesson; Wenyu Zhou; Erica C Jonlin; Antonio J Jimenez-Caliani; Xinxian Deng; Christopher Cavanaugh; Savannah Cook; Paul J Tesar; Jeffrey Okada; Lilyana Margaretha; Henrik Sperber; Michael Choi; C Anthony Blau; Piper M Treuting; R David Hawkins; Vincenzo Cirulli; Hannele Ruohola-Baker
Journal:  Proc Natl Acad Sci U S A       Date:  2014-03-12       Impact factor: 11.205

8.  Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells.

Authors:  Ryoko Araki; Masahiro Uda; Yuko Hoki; Misato Sunayama; Miki Nakamura; Shunsuke Ando; Mayumi Sugiura; Hisashi Ideno; Akemi Shimada; Akira Nifuji; Masumi Abe
Journal:  Nature       Date:  2013-01-09       Impact factor: 49.962

9.  Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs.

Authors:  Gabsang Lee; Eirini P Papapetrou; Hyesoo Kim; Stuart M Chambers; Mark J Tomishima; Christopher A Fasano; Yosif M Ganat; Jayanthi Menon; Fumiko Shimizu; Agnes Viale; Viviane Tabar; Michel Sadelain; Lorenz Studer
Journal:  Nature       Date:  2009-08-19       Impact factor: 49.962

10.  Resetting transcription factor control circuitry toward ground-state pluripotency in human.

Authors:  Yasuhiro Takashima; Ge Guo; Remco Loos; Jennifer Nichols; Gabriella Ficz; Felix Krueger; David Oxley; Fatima Santos; James Clarke; William Mansfield; Wolf Reik; Paul Bertone; Austin Smith
Journal:  Cell       Date:  2014-09-11       Impact factor: 41.582
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  34 in total

Review 1.  Advances in predictive in vitro models of drug-induced nephrotoxicity.

Authors:  Joanne Y-C Soo; Jitske Jansen; Rosalinde Masereeuw; Melissa H Little
Journal:  Nat Rev Nephrol       Date:  2018-06       Impact factor: 28.314

Review 2.  Dental pulp stem cells for the study of neurogenetic disorders.

Authors:  A Kaitlyn Victor; Lawrence T Reiter
Journal:  Hum Mol Genet       Date:  2017-10-01       Impact factor: 6.150

Review 3.  Targeting innate immunity for neurodegenerative disorders of the central nervous system.

Authors:  Katrin I Andreasson; Adam D Bachstetter; Marco Colonna; Florent Ginhoux; Clive Holmes; Bruce Lamb; Gary Landreth; Daniel C Lee; Donovan Low; Marina A Lynch; Alon Monsonego; M Kerry O'Banion; Milos Pekny; Till Puschmann; Niva Russek-Blum; Leslie A Sandusky; Maj-Linda B Selenica; Kazuyuki Takata; Jessica Teeling; Terrence Town; Linda J Van Eldik
Journal:  J Neurochem       Date:  2016-09       Impact factor: 5.372

Review 4.  Hydrogel Scaffolds: Towards Restitution of Ischemic Stroke-Injured Brain.

Authors:  Aswathi Gopalakrishnan; Sahadev A Shankarappa; G K Rajanikant
Journal:  Transl Stroke Res       Date:  2018-08-27       Impact factor: 6.829

5.  Nuclear S-Nitrosylation Defines an Optimal Zone for Inducing Pluripotency.

Authors:  Palas K Chanda; Shu Meng; Jieun Lee; Honchiu E Leung; Kaifu Chen; John P Cooke
Journal:  Circulation       Date:  2019-08-15       Impact factor: 29.690

6.  Mouse Parthenogenetic Embryonic Stem Cells with Biparental-Like Expression of Imprinted Genes Generate Cortical-Like Neurons That Integrate into the Injured Adult Cerebral Cortex.

Authors:  Annie Varrault; Sigrid Eckardt; Benoît Girard; Anne Le Digarcher; Isabelle Sassetti; Céline Meusnier; Chantal Ripoll; Armen Badalyan; Federica Bertaso; K John McLaughlin; Laurent Journot; Tristan Bouschet
Journal:  Stem Cells       Date:  2017-11-10       Impact factor: 6.277

Review 7.  Rethinking nomenclature for interspecies cell fusions.

Authors:  Bryan J Pavlovic; Dov Fox; Nathan K Schaefer; Alex A Pollen
Journal:  Nat Rev Genet       Date:  2022-01-26       Impact factor: 53.242

Review 8.  Developing Bottom-Up Induced Pluripotent Stem Cell Derived Solid Tumor Models Using Precision Genome Editing Technologies.

Authors:  Kelsie L Becklin; Garrett M Draper; Rebecca A Madden; Mitchell G Kluesner; Tomoyuki Koga; Miller Huang; William A Weiss; Logan G Spector; David A Largaespada; Branden S Moriarity; Beau R Webber
Journal:  CRISPR J       Date:  2022-08

9.  Induced pluripotent stem cell-derived mesenchymal stem cells deliver exogenous miR-105-5p via small extracellular vesicles to rejuvenate senescent nucleus pulposus cells and attenuate intervertebral disc degeneration.

Authors:  Yongjin Sun; Wenzhi Zhang; Xu Li
Journal:  Stem Cell Res Ther       Date:  2021-05-13       Impact factor: 6.832

10.  Age-Related Macular Degeneration: From Epigenetics to Therapeutic Implications.

Authors:  Michael H Farkas; Margaret M DeAngelis
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 3.650
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