Literature DB >> 26415686

Imaging disulfide dinitroxides at 250 MHz to monitor thiol redox status.

Hanan Elajaili1, Joshua R Biller1, Gerald M Rosen2, Joseph P Y Kao3, Mark Tseytlin1, Laura A Buchanan1, George A Rinard4, Richard W Quine4, Joseph McPeak1, Yilin Shi1, Sandra S Eaton1, Gareth R Eaton5.   

Abstract

Measurement of thiol-disulfide redox status is crucial for characterization of tumor physiology. The electron paramagnetic resonance (EPR) spectra of disulfide-linked dinitroxides are readily distinguished from those of the corresponding monoradicals that are formed by cleavage of the disulfide linkage by free thiols. EPR spectra can thus be used to monitor the rate of cleavage and the thiol redox status. EPR spectra of (1)H,(14)N- and (2)H,(15)N-disulfide dinitroxides and the corresponding monoradicals resulting from cleavage by glutathione have been characterized at 250 MHz, 1.04 GHz, and 9 GHz and imaged by rapid-scan EPR at 250 MHz.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Disulfide cleavage; Disulfide dinitroxide; Glutathione; Image reconstruction; Rapid-scan EPR; Thiol redox status

Mesh：

Substances：

Year:  2015        PMID： 26415686      PMCID： PMC4731354          DOI： 10.1016/j.jmr.2015.08.027

Source DB:  PubMed          Journal:  J Magn Reson        ISSN： 1090-7807            Impact factor:   2.229


  20 in total

1.  X-band rapid-scan EPR of nitroxyl radicals.

Authors:  Deborah G Mitchell; Richard W Quine; Mark Tseitlin; Sandra S Eaton; Gareth R Eaton
Journal:  J Magn Reson       Date:  2011-11-20       Impact factor: 2.229

2.  Comparison of Continuous Wave, Spin Echo, and Rapid Scan EPR of Irradiated Fused Quartz.

Authors:  Deborah G Mitchell; Richard W Quine; Mark Tseitlin; Virginia Meyer; Sandra S Eaton; Gareth R Eaton
Journal:  Radiat Meas       Date:  2011-09       Impact factor: 1.898

3.  Blood flow, tissue oxygenation, pH distribution, and energy metabolism of murine mammary adenocarcinomas during growth.

Authors:  P Vaupel; P Okunieff; L J Neuringer
Journal:  Adv Exp Med Biol       Date:  1989       Impact factor: 2.622

4.  Quantitative rapid scan EPR spectroscopy at 258 MHz.

Authors:  Richard W Quine; George A Rinard; Sandra S Eaton; Gareth R Eaton
Journal:  J Magn Reson       Date:  2010-03-21       Impact factor: 2.229

5.  In vivo monitoring of pH, redox status, and glutathione using L-band EPR for assessment of therapeutic effectiveness in solid tumors.

Authors:  Andrey A Bobko; Timothy D Eubank; Jeffrey L Voorhees; Olga V Efimova; Igor A Kirilyuk; Sergey Petryakov; Dmitrii G Trofimiov; Clay B Marsh; Jay L Zweier; Igor A Grigor'ev; Alexandre Samouilov; Valery V Khramtsov
Journal:  Magn Reson Med       Date:  2011-11-23       Impact factor: 4.668

6.  A Wire Crossed-Loop-Resonator for Rapid Scan EPR.

Authors:  George A Rinard; Richard W Quine; Joshua R Biller; Gareth R Eaton
Journal:  Concepts Magn Reson Part B Magn Reson Eng       Date:  2010-04-09       Impact factor: 1.176

7.  Improved sensitivity for imaging spin trapped hydroxyl radical at 250 MHz.

Authors:  Joshua R Biller; Mark Tseitlin; Deborah G Mitchell; Zhelin Yu; Laura A Buchanan; Hanan Elajaili; Gerald M Rosen; Joseph P Y Kao; Sandra S Eaton; Gareth R Eaton
Journal:  Chemphyschem       Date:  2014-12-08       Impact factor: 3.102

8.  Corrections for sinusoidal background and non-orthogonality of signal channels in sinusoidal rapid magnetic field scans.

Authors:  Mark Tseitlin; Deborah G Mitchell; Sandra S Eaton; Gareth R Eaton
Journal:  J Magn Reson       Date:  2012-08-08       Impact factor: 2.229

9.  New spectral-spatial imaging algorithm for full EPR spectra of multiline nitroxides and pH sensitive trityl radicals.

Authors:  Mark Tseitlin; Joshua R Biller; Hanan Elajaili; Valery V Khramtsov; Ilirian Dhimitruka; Gareth R Eaton; Sandra S Eaton
Journal:  J Magn Reson       Date:  2014-06-17       Impact factor: 2.229

10.  Electron paramagnetic resonance oxygen image hypoxic fraction plus radiation dose strongly correlates with tumor cure in FSa fibrosarcomas.

Authors:  Martyna Elas; Rebecca Bell; Danielle Hleihel; Eugene D Barth; Colin McFaul; Chad R Haney; Joanna Bielanska; Katarzyna Pustelny; Kang-Hyun Ahn; Charles A Pelizzari; Masha Kocherginsky; Howard J Halpern
Journal:  Int J Radiat Oncol Biol Phys       Date:  2008-06-01       Impact factor: 7.038
View more
  11 in total

1.  Rapid-Scan EPR of Nitroxide Spin Labels and Semiquinones.

Authors:  Sandra S Eaton; Gareth R Eaton
Journal:  Methods Enzymol       Date:  2015-08-01       Impact factor: 1.600

2.  Rapid Scan Electron Paramagnetic Resonance Opens New Avenues for Imaging Physiologically Important Parameters In Vivo.

Authors:  Joshua R Biller; Deborah G Mitchell; Mark Tseytlin; Hanan Elajaili; George A Rinard; Richard W Quine; Sandra S Eaton; Gareth R Eaton
Journal:  J Vis Exp       Date:  2016-09-26       Impact factor: 1.355

3.  Imaging thiol redox status in murine tumors in vivo with rapid-scan electron paramagnetic resonance.

Authors:  Boris Epel; Subramanian V Sundramoorthy; Martyna Krzykawska-Serda; Matthew C Maggio; Mark Tseytlin; Gareth R Eaton; Sandra S Eaton; Gerald M Rosen; Joseph P Y Kao; Howard J Halpern
Journal:  J Magn Reson       Date:  2016-12-31       Impact factor: 2.229

Review 4.  Exchange Phenomena in the Electron Paramagnetic Resonance Spectra of the Nitroxyl and Trityl Radicals: Multifunctional Spectroscopy and Imaging of Local Chemical Microenvironment.

Authors:  Valery V Khramtsov; Andrey A Bobko; Mark Tseytlin; Benoit Driesschaert
Journal:  Anal Chem       Date:  2017-04-10       Impact factor: 6.986

Review 5.  In Vivo Molecular Electron Paramagnetic Resonance-Based Spectroscopy and Imaging of Tumor Microenvironment and Redox Using Functional Paramagnetic Probes.

Authors:  Valery V Khramtsov
Journal:  Antioxid Redox Signal       Date:  2017-12-20       Impact factor: 8.401

Review 6.  Rapid-scan EPR imaging.

Authors:  Sandra S Eaton; Yilin Shi; Lukas Woodcock; Laura A Buchanan; Joseph McPeak; Richard W Quine; George A Rinard; Boris Epel; Howard J Halpern; Gareth R Eaton
Journal:  J Magn Reson       Date:  2017-07       Impact factor: 2.229

7.  Resonators for In Vivo Imaging: Practical Experience.

Authors:  George A Rinard; Richard W Quine; Laura A Buchanan; Sandra S Eaton; Gareth R Eaton; Boris Epel; Subramanian V Sundramoorthy; Howard J Halpern
Journal:  Appl Magn Reson       Date:  2017-09-22       Impact factor: 0.831

8.  Use of Electron Paramagnetic Resonance in Biological Samples at Ambient Temperature and 77 K.

Authors:  Hanan B Elajaili; Laura Hernandez-Lagunas; Kalina Ranguelova; Sergey Dikalov; Eva Nozik-Grayck
Journal:  J Vis Exp       Date:  2019-01-11       Impact factor: 1.355

9.  Rapid-scan EPR imaging of a phantom comprised of species with different linewidths and relaxation times.

Authors:  Yilin Shi; Sandra S Eaton; Gareth R Eaton
Journal:  J Magn Reson       Date:  2019-09-07       Impact factor: 2.229

Review 10.  EPR Everywhere.

Authors:  Joshua R Biller; Joseph E McPeak
Journal:  Appl Magn Reson       Date:  2021-01-24       Impact factor: 0.831
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.