STUDY OBJECTIVES: To report two female patients with paraneoplastic cerebellar degeneration (PCD) related to breast cancer that presented with rapid eye movement-sleep behavior disorder (RBD) and improved sleep symptoms with immunotherapy. METHODS: The two patients were evaluated through clinical scale and polysomnography before and after therapy with intravenous immunoglobulin. RESULTS: RBD was successfully treated with immunotherapy in both patients. Score on the RBD screening questionnaire dropped from 10 to 1 or 0, allied with the normalization of polysomnographic findings. CONCLUSIONS: A marked improvement in RBD after immunotherapy in PCD raises the hypothesis that secondary RBD may be an immune-mediated sleep disorder.
STUDY OBJECTIVES: To report two female patients with paraneoplastic cerebellar degeneration (PCD) related to breast cancer that presented with rapid eye movement-sleep behavior disorder (RBD) and improved sleep symptoms with immunotherapy. METHODS: The two patients were evaluated through clinical scale and polysomnography before and after therapy with intravenous immunoglobulin. RESULTS: RBD was successfully treated with immunotherapy in both patients. Score on the RBD screening questionnaire dropped from 10 to 1 or 0, allied with the normalization of polysomnographic findings. CONCLUSIONS: A marked improvement in RBD after immunotherapy in PCD raises the hypothesis that secondary RBD may be an immune-mediated sleep disorder.
Authors: V Cochen; I Arnulf; S Demeret; M L Neulat; V Gourlet; X Drouot; S Moutereau; J P Derenne; T Similowski; J C Willer; C Pierrot-Deseiligny; F Bolgert Journal: Brain Date: 2005-07-06 Impact factor: 13.501
Authors: Alex Iranzo; Francesc Graus; Linda Clover; Jaume Morera; Jordi Bruna; Carlos Vilar; José Enrique Martínez-Rodriguez; Angela Vincent; Joan Santamaría Journal: Ann Neurol Date: 2006-01 Impact factor: 10.422
Authors: Thomas Gaughan; Ashura Buckley; Rebecca Hommer; Paul Grant; Kyle Williams; James F Leckman; Susan E Swedo Journal: J Clin Sleep Med Date: 2016-07-15 Impact factor: 4.062