Thomas Gaughan1, Ashura Buckley1, Rebecca Hommer1, Paul Grant1, Kyle Williams2, James F Leckman3, Susan E Swedo1. 1. Department of Pediatrics and Developmental Neuroscience, National Institute of Mental Health, Bethesda, MD. 2. Pediatric Neuropsychiatry and Immunology Program, Massachusetts General Hospital, Harvard University School of Medicine, Boston, MA. 3. Child Study Center, Yale University School of Medicine, New Haven, CT.
Abstract
STUDY OBJECTIVES: Polysomnographic investigation of sleep architecture in children presenting with pediatric acute-onset neuropsychiatric syndrome (PANS). METHODS: Fifteen consecutive subjects meeting criteria for PANS (mean age = 7.2 y; range 3-10 y) underwent single-night full polysomnography (PSG) read by a pediatric neurologist. RESULTS: Thirteen of 15 subjects (87%) had abnormalities detected with PSG. Twelve of 15 had evidence of rapid eye movement (REM) sleep motor disinhibition, as characterized by excessive movement, laughing, hand stereotypies, moaning, or the continuation of periodic limb movements during sleep (PLMS) into REM sleep. CONCLUSIONS: This study shows various forms of REM sleep motor disinhibition present in a population of children with PANS.
STUDY OBJECTIVES: Polysomnographic investigation of sleep architecture in children presenting with pediatric acute-onset neuropsychiatric syndrome (PANS). METHODS: Fifteen consecutive subjects meeting criteria for PANS (mean age = 7.2 y; range 3-10 y) underwent single-night full polysomnography (PSG) read by a pediatric neurologist. RESULTS: Thirteen of 15 subjects (87%) had abnormalities detected with PSG. Twelve of 15 had evidence of rapid eye movement (REM) sleep motor disinhibition, as characterized by excessive movement, laughing, hand stereotypies, moaning, or the continuation of periodic limb movements during sleep (PLMS) into REM sleep. CONCLUSIONS: This study shows various forms of REM sleep motor disinhibition present in a population of children with PANS.
Authors: V Cochen; I Arnulf; S Demeret; M L Neulat; V Gourlet; X Drouot; S Moutereau; J P Derenne; T Similowski; J C Willer; C Pierrot-Deseiligny; F Bolgert Journal: Brain Date: 2005-07-06 Impact factor: 13.501
Authors: B F Boeve; M H Silber; J E Parisi; D W Dickson; T J Ferman; E E Benarroch; A M Schmeichel; G E Smith; R C Petersen; J E Ahlskog; J Y Matsumoto; D S Knopman; C H Schenck; M W Mahowald Journal: Neurology Date: 2003-07-08 Impact factor: 9.910
Authors: S Cohrs; T Rasch; S Altmeyer; J Kinkelbur; T Kostanecka; A Rothenberger; E Rüther; G Hajak Journal: J Neurol Neurosurg Psychiatry Date: 2001-02 Impact factor: 10.154
Authors: Jimmy Zheng; Jennifer Frankovich; Emily S McKenna; Nathan C Rowe; Sarah J MacEachern; Nathan N Ng; Lydia T Tam; Peter K Moon; Jaynelle Gao; Margo Thienemann; Nils D Forkert; Kristen W Yeom Journal: JAMA Netw Open Date: 2020-05-01