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Literature DB >> 26413260

A Nanocrystal-based Ratiometric pH Sensor for Natural pH Ranges.

Rebecca C Somers¹, Ryan M Lanning², Preston T Snee¹, Andrew B Greytak¹, Rakesh K Jain², Moungi G Bawendi¹, Daniel G Nocera¹.

Abstract

A ratiometric fluorescent pH sensor based on CdSe/CdZnS nanocrystal quantum dots (NCs) has been designed for biological pH ranges. The construct is formed from the conjugation of a pH dye (SNARF) to NCs coated with a poly(amido amine) (PAMAM) dendrimer. The sensor exhibits a well-resolved ratio response at pH values between 6 and 8 under linear or two-photon excitation, and in the presence of a 4% bovine serum albumin (BSA) solution.

Entities: Chemical Disease Gene Species

Year: 2012 PMID： 26413260 PMCID： PMC4582792 DOI： 10.1039/C2SC20212C

Source DB: PubMed Journal: Chem Sci ISSN： 2041-6520 Impact factor: 9.825

31 in total

1. Synthesis of compact multidentate ligands to prepare stable hydrophilic quantum dot fluorophores.

Authors: H Tetsuo Uyeda; Igor L Medintz; Jyoti K Jaiswal; Sanford M Simon; Hedi Mattoussi
Journal: J Am Chem Soc Date: 2005-03-23 Impact factor: 15.419

2. A ratiometric CdSe/ZnS nanocrystal pH sensor.

Authors: Preston T Snee; Rebecca C Somers; Gautham Nair; John P Zimmer; Moungi G Bawendi; Daniel G Nocera
Journal: J Am Chem Soc Date: 2006-10-18 Impact factor: 15.419

Review 3. CdSe nanocrystal based chem-/bio- sensors.

Authors: Rebecca C Somers; Moungi G Bawendi; Daniel G Nocera
Journal: Chem Soc Rev Date: 2007-02-27 Impact factor: 54.564

4. Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation.

Authors: G Helmlinger; F Yuan; M Dellian; R K Jain
Journal: Nat Med Date: 1997-02 Impact factor: 53.440

5. Two-photon laser scanning fluorescence microscopy.

Authors: W Denk; J H Strickler; W W Webb
Journal: Science Date: 1990-04-06 Impact factor: 47.728

6. A hybrid quantum dot-antibody fragment fluorescence resonance energy transfer-based TNT sensor.

Authors: Ellen R Goldman; Igor L Medintz; Jessica L Whitley; Andrew Hayhurst; Aaron R Clapp; H Tetsuo Uyeda; Jeffrey R Deschamps; Michael E Lassman; Hedi Mattoussi
Journal: J Am Chem Soc Date: 2005-05-11 Impact factor: 15.419

7. Quantum-dot/dopamine bioconjugates function as redox coupled assemblies for in vitro and intracellular pH sensing.

Authors: Igor L Medintz; Michael H Stewart; Scott A Trammell; Kimihiro Susumu; James B Delehanty; Bing C Mei; Joseph S Melinger; Juan B Blanco-Canosa; Philip E Dawson; Hedi Mattoussi
Journal: Nat Mater Date: 2010-08 Impact factor: 43.841

8. A nanoparticle size series for in vivo fluorescence imaging.

Authors: Zoran Popović; Wenhao Liu; Vikash P Chauhan; Jungmin Lee; Cliff Wong; Andrew B Greytak; Numpon Insin; Daniel G Nocera; Dai Fukumura; Rakesh K Jain; Moungi G Bawendi
Journal: Angew Chem Int Ed Engl Date: 2010-11-08 Impact factor: 15.336

Review 9. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy.

Authors: Rakesh K Jain
Journal: Science Date: 2005-01-07 Impact factor: 47.728

10. Water-soluble quantum dots for multiphoton fluorescence imaging in vivo.

Authors: Daniel R Larson; Warren R Zipfel; Rebecca M Williams; Stephen W Clark; Marcel P Bruchez; Frank W Wise; Watt W Webb
Journal: Science Date: 2003-05-30 Impact factor: 47.728

11 in total

1. Sensing with photoluminescent semiconductor quantum dots.

Authors: Margaret Chern; Joshua C Kays; Shashi Bhuckory; Allison M Dennis
Journal: Methods Appl Fluoresc Date: 2019-01-24 Impact factor: 3.009

2. Optical imaging of tumor microenvironment.

Authors: Yihan Wu; Wenjie Zhang; Jinbo Li; Yan Zhang
Journal: Am J Nucl Med Mol Imaging Date: 2013-01-05

Review 3. Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior.

Authors: Miles A Miller; Ralph Weissleder
Journal: Adv Drug Deliv Rev Date: 2016-06-04 Impact factor: 15.470

A Nanocrystal-based Ratiometric pH Sensor for Natural pH Ranges.

1. Synthesis of compact multidentate ligands to prepare stable hydrophilic quantum dot fluorophores.

2. A ratiometric CdSe/ZnS nanocrystal pH sensor.

Review 3. CdSe nanocrystal based chem-/bio- sensors.

4. Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation.

5. Two-photon laser scanning fluorescence microscopy.

6. A hybrid quantum dot-antibody fragment fluorescence resonance energy transfer-based TNT sensor.

7. Quantum-dot/dopamine bioconjugates function as redox coupled assemblies for in vitro and intracellular pH sensing.

8. A nanoparticle size series for in vivo fluorescence imaging.

Review 9. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy.

10. Water-soluble quantum dots for multiphoton fluorescence imaging in vivo.

1. Sensing with photoluminescent semiconductor quantum dots.

2. Optical imaging of tumor microenvironment.

Review 3. Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior.

4. Optical Sensing and Imaging of pH Values: Spectroscopies, Materials, and Applications.

5. Rational design of a colorimetric pH sensor from a soluble retinoic acid chaperone.

6. Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies as in Vivo Two-Photon Oxygen Sensors.

7. Ratiometric fluorescent pH-sensitive polymers for high-throughput monitoring of extracellular pH.

8. A plug-and-play ratiometric pH-sensing nanoprobe for high-throughput investigation of endosomal escape.

9. Conformational control of energy transfer: a mechanism for biocompatible nanocrystal-based sensors.

10. Metabolic tumor profiling with pH, oxygen, and glucose chemosensors on a quantum dot scaffold.