Literature DB >> 25771015

A plug-and-play ratiometric pH-sensing nanoprobe for high-throughput investigation of endosomal escape.

Zhou J Deng1, Stephen W Morton1, Daniel K Bonner1, Li Gu1, Hooisweng Ow2, Paula T Hammond1.   

Abstract

An important aspect in the design of nanomaterials for delivery is an understanding of its uptake and ultimate release to the cytosol of target cells. Real-time chemical sensing using a nanoparticle-based platform affords exquisite insight into the trafficking of materials and their cargo into cells. This versatile and tunable technology provides a powerful tool to probe the mechanism of cellular entry and cytosolic delivery of a variety of materials, allowing for a simple and convenient means to screen materials towards efficient delivery of therapeutics such as nucleic acids.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Chemical sensing; Delivery; Endosomal escape; Nanoparticle; Nanotechnology

Mesh：

Substances：

Year:  2015        PMID： 25771015      PMCID： PMC4387846          DOI： 10.1016/j.biomaterials.2015.02.013

Source DB:  PubMed          Journal:  Biomaterials        ISSN： 0142-9612            Impact factor:   12.479


  32 in total

1.  Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape.

Authors:  Jerome Gilleron; William Querbes; Anja Zeigerer; Anna Borodovsky; Giovanni Marsico; Undine Schubert; Kevin Manygoats; Sarah Seifert; Cordula Andree; Martin Stöter; Hila Epstein-Barash; Ligang Zhang; Victor Koteliansky; Kevin Fitzgerald; Eugenio Fava; Marc Bickle; Yannis Kalaidzidis; Akin Akinc; Martin Maier; Marino Zerial
Journal:  Nat Biotechnol       Date:  2013-06-23       Impact factor: 54.908

2.  Synergistic silencing: combinations of lipid-like materials for efficacious siRNA delivery.

Authors:  Kathryn A Whitehead; Gaurav Sahay; George Z Li; Kevin T Love; Christopher A Alabi; Minglin Ma; Christopher Zurenko; William Querbes; Robert S Langer; Daniel G Anderson
Journal:  Mol Ther       Date:  2011-07-12       Impact factor: 11.454

3.  Quantum dot-fluorescent protein FRET probes for sensing intracellular pH.

Authors:  Allison M Dennis; Won Jong Rhee; David Sotto; Steven N Dublin; Gang Bao
Journal:  ACS Nano       Date:  2012-04-02       Impact factor: 15.881

4.  Mechanism of polyplex- and lipoplex-mediated delivery of nucleic acids: real-time visualization of transient membrane destabilization without endosomal lysis.

Authors:  Zia ur Rehman; Dick Hoekstra; Inge S Zuhorn
Journal:  ACS Nano       Date:  2013-04-24       Impact factor: 15.881

Review 5.  Sugar-based amphiphilic polymers for biomedical applications: from nanocarriers to therapeutics.

Authors:  Li Gu; Allison Faig; Dalia Abdelhamid; Kathryn Uhrich
Journal:  Acc Chem Res       Date:  2014-08-20       Impact factor: 22.384

Review 6.  Cellular uptake, intracellular trafficking, and cytotoxicity of nanomaterials.

Authors:  Feng Zhao; Ying Zhao; Ying Liu; Xueling Chang; Chunying Chen; Yuliang Zhao
Journal:  Small       Date:  2011-04-26       Impact factor: 13.281

7.  Systemic delivery of DNA or siRNA mediated by linear polyethylenimine (L-PEI) does not induce an inflammatory response.

Authors:  Marie-Elise Bonnet; Patrick Erbacher; Anne-Laure Bolcato-Bellemin
Journal:  Pharm Res       Date:  2008-08-16       Impact factor: 4.200

8.  Cationic amphiphilic macromolecule (CAM)-lipid complexes for efficient siRNA gene silencing.

Authors:  Li Gu; Leora M Nusblat; Nasim Tishbi; Sarah C Noble; Chaya M Pinson; Evan Mintzer; Charles M Roth; Kathryn E Uhrich
Journal:  J Control Release       Date:  2014-04-13       Impact factor: 9.776

9.  Effect of bafilomycin A1 and nocodazole on endocytic transport in HeLa cells: implications for viral uncoating and infection.

Authors:  N Bayer; D Schober; E Prchla; R F Murphy; D Blaas; R Fuchs
Journal:  J Virol       Date:  1998-12       Impact factor: 5.103

10.  Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling.

Authors:  Gaurav Sahay; William Querbes; Christopher Alabi; Ahmed Eltoukhy; Sovan Sarkar; Christopher Zurenko; Emmanouil Karagiannis; Kevin Love; Delai Chen; Roberto Zoncu; Yosef Buganim; Avi Schroeder; Robert Langer; Daniel G Anderson
Journal:  Nat Biotechnol       Date:  2013-06-23       Impact factor: 54.908
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  3 in total

1.  A Redox-Activatable Fluorescent Sensor for the High-Throughput Quantification of Cytosolic Delivery of Macromolecules.

Authors:  Zhaohui Wang; Min Luo; Chengqiong Mao; Qi Wei; Tian Zhao; Yang Li; Gang Huang; Jinming Gao
Journal:  Angew Chem Int Ed Engl       Date:  2016-12-16       Impact factor: 15.336

2.  Theranostic Layer-by-Layer Nanoparticles for Simultaneous Tumor Detection and Gene Silencing.

Authors:  Natalie Boehnke; Santiago Correa; Liangliang Hao; Wade Wang; Joelle P Straehla; Sangeeta N Bhatia; Paula T Hammond
Journal:  Angew Chem Int Ed Engl       Date:  2020-01-07       Impact factor: 15.336

3.  siRNA-loaded poly(histidine-arginine)6-modified chitosan nanoparticle with enhanced cell-penetrating and endosomal escape capacities for suppressing breast tumor metastasis.

Authors:  Ping Sun; Wei Huang; Lin Kang; Mingji Jin; Bo Fan; Hongyan Jin; Qi-Ming Wang; Zhonggao Gao
Journal:  Int J Nanomedicine       Date:  2017-04-19
  3 in total

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