Pietro-Luca Ratti1, Laurence Nègre-Pagès2, Santiago Pérez-Lloret3, Raffaele Manni4, Philippe Damier5, François Tison6, Alain Destée7, Olivier Rascol8. 1. Department of Clinical Pharmacology, Paul Sabatier University and Toulouse University Hospital, Toulouse, France; INSERM UMR825 Neuroimaging and Neurologic Diseases, Toulouse, France; Sleep and Epilepsy Center, Neurocenter of Southern Switzerland, Civic Hospital (EOC) of Lugano, Switzerland. Electronic address: pietroluca.ratti@eoc.ch. 2. Department of Clinical Pharmacology, Paul Sabatier University and Toulouse University Hospital, Toulouse, France; LN-Pharma, Toulouse, France. 3. Department of Clinical Pharmacology, Paul Sabatier University and Toulouse University Hospital, Toulouse, France. 4. Sleep Medicine and Epilepsy Unit, IRCCS "C. Mondino National Institute of Neurology" Foundation, Pavia, Italy. 5. Pôle Neurosciences, Centre Hospitalier Universitaire de Nantes, Centre d'Investigation Clinique CIC 04, Nantes, France. 6. Service de Neurologie, Groupe Hospitalier Sud, Hôpital Haut-Lévèque, Centre Hospitalier Universitaire de Bordeaux, France. 7. Service de Neurologie et pathologie du mouvement, Pôle de Neurologie, Centre Hospitalier Universitaire de Lille, France. 8. Department of Clinical Pharmacology, Paul Sabatier University and Toulouse University Hospital, Toulouse, France; INSERM UMR825 Neuroimaging and Neurologic Diseases, Toulouse, France; Centre d'Investigation Clinique CIC 9302, Toulouse University Hospital, Toulouse, France.
Abstract
INTRODUCTION: Twenty-seven to 80% of patients with Parkinson's Disease (PD) complain of subjective sleep dysfunction and insomnia symptoms. Our aim is to describe the prevalence and features of subjective sleep dysfunction and insomnia symptoms in patients with PD compared to other patients. METHODS: Cross-sectional analysis of 636 adult PD patients compared to 143 age and sex-matched non-PD control patients consulting their general practitioners. Insomnia symptoms and other sleep features were assessed by the Pittsburgh Sleep Quality Index (PSQI), a global score > 5 defining impaired sleep. The Chi-square test or the Student's t-test were used to assess the potential clinical and demographic differences between groups and between PD patients with vs. without sleep dysfunction. Logistic regression analysis was employed to test multivariate effects. RESULTS: Sleep dysfunction and insomnia symptoms were more frequent in PD patients compared to control patients (63 vs. 45%, p = 0.001). Female gender, PD duration, presence of depression and anxiety were associated with the presence of insomnia in PD. Subjective sleep efficiency, habitual sleep quality, sleep disturbance and daytime dysfunction, but not sleep latency, were reduced in PD patients compared to controls. CONCLUSIONS: The prevalence of sleep dysfunction is higher in PD than in other general medical conditions. Insomnia in PD seems to affect sleep maintenance and consolidation, but not sleep onset.
INTRODUCTION: Twenty-seven to 80% of patients with Parkinson's Disease (PD) complain of subjective sleep dysfunction and insomnia symptoms. Our aim is to describe the prevalence and features of subjective sleep dysfunction and insomnia symptoms in patients with PD compared to other patients. METHODS: Cross-sectional analysis of 636 adult PDpatients compared to 143 age and sex-matched non-PD control patients consulting their general practitioners. Insomnia symptoms and other sleep features were assessed by the Pittsburgh Sleep Quality Index (PSQI), a global score > 5 defining impaired sleep. The Chi-square test or the Student's t-test were used to assess the potential clinical and demographic differences between groups and between PDpatients with vs. without sleep dysfunction. Logistic regression analysis was employed to test multivariate effects. RESULTS:Sleep dysfunction and insomnia symptoms were more frequent in PDpatients compared to control patients (63 vs. 45%, p = 0.001). Female gender, PD duration, presence of depression and anxiety were associated with the presence of insomnia in PD. Subjective sleep efficiency, habitual sleep quality, sleep disturbance and daytime dysfunction, but not sleep latency, were reduced in PDpatients compared to controls. CONCLUSIONS: The prevalence of sleep dysfunction is higher in PD than in other general medical conditions. Insomnia in PD seems to affect sleep maintenance and consolidation, but not sleep onset.
Authors: Sonja Rutten; Chris Vriend; Ysbrand D van der Werf; Henk W Berendse; Daniel Weintraub; Odile A van den Heuvel Journal: Parkinsonism Relat Disord Date: 2017-02-01 Impact factor: 4.891
Authors: Sonja Rutten; Chris Vriend; Jan H Smit; Henk W Berendse; Adriaan W Hoogendoorn; Odile A van den Heuvel; Ysbrand D van der Werf Journal: BMC Psychiatry Date: 2016-10-21 Impact factor: 3.630