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Literature DB >> 26408913

Automated production of [¹⁸F]VAT suitable for clinical PET study of vesicular acetylcholine transporter.

Xuyi Yue¹, Christopher Bognar¹, Xiang Zhang¹, Gregory G Gaehle¹, Stephen M Moerlein¹, Joel S Perlmutter¹, Zhude Tu².

Abstract

Automated production of a promising radiopharmaceutical (-)-(1-(8-(2-[(18)F]fluoroethoxy)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)-piperidin-4-yl)(4-fluorophenyl)methanone ([(18)F]VAT) for the vesicular acetylcholine transporter(VAChT) was achieved using a two-step procedure in a current Good Manufacturing Practices fashion. The production of [(18)F]VAT was accomplished in approximately 140 min, with radiochemical yield of ~15.0% (decay corrected), specific activity>111 GBq/µmol, radiochemical purity>99% and mass of VAT ~3.4 μg/batch (n>10). The radiopharmaceutical product meets all quality control criteria for human use, and is suitable for clinical PET studies of VAChT.

Entities: Chemical Disease Gene Species

Keywords: Automation; Clinical studies; Fluorine-18; Positron emission tomography; Vesicular acetylcholine transporter

Mesh：

Substances：

Year: 2015 PMID： 26408913 PMCID： PMC4681605 DOI： 10.1016/j.apradiso.2015.09.010

Source DB: PubMed Journal: Appl Radiat Isot ISSN： 0969-8043 Impact factor: 1.513

21 in total

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6 in total

1. Kinetic modeling of [¹⁸ F]VAT, a novel radioligand for positron emission tomography imaging vesicular acetylcholine transporter in non-human primate brain.

Authors: Hongjun Jin; Xuyi Yue; Hui Liu; Junbin Han; Hubert Flores; Yi Su; Stanley M Parsons; Joel S Perlmutter; Zhude Tu
Journal: J Neurochem Date: 2018-03-25 Impact factor: 5.372

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Authors: Xuyi Yue; Hongjun Jin; Hui Liu; Zonghua Luo; Xiang Zhang; Kota Kaneshige; Hubert P Flores; Joel S Perlmutter; Stanley M Parsons; Zhude Tu
Journal: Org Biomol Chem Date: 2017-06-21 Impact factor: 3.876

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