Omar A Abdul-Rahman1, Beatriz Rodriguez2, Sandra R Wadlinger3, Julia Slutsman4, Elizabeth B Boyle5, Lori S Merrill5, Jeffrey Botkin6, Jack Moye4. 1. Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi. 2. University of Hawaii, Honolulu, Hawaii. 3. The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. 4. National Children's Study Program Office, NICHD, NIH, Bethesda, Maryland. 5. Westat, Rockville, Maryland. 6. University of Utah, Salt Lake City, Utah.
Abstract
BACKGROUND: The National Children's Study (NCS) Vanguard Study began enrollment in January 2009 as an initial pilot study for a planned large-scale, longitudinal U.S. cohort study of the effect of environmental influences on child health and development, with biological and environmental sample collection conducted in seven locations from April 2009 to October 2010. We sought to determine rates of consent for, and success of collection of, maternal and paternal biospecimens before and during pregnancy in the NCS Vanguard Study. METHODS: Samples of blood, saliva, vaginal swabs, urine, hair, and nails were collected before and during pregnancy. All specimens were sent to a central repository for processing, storage, and quality assessment. RESULTS: Of 780 pregnant women asked to consent to sample collection, 773 (>99%) agreed, and of 295 nonpregnant women, 292 (99%) agreed. Of 440 fathers asked to consent to sample collection, 435 (99%) agreed. Frequency of successful collection of biospecimens varied depending on sample and visit type. In descending order, the ranges over all visit types of the proportion of expected samples successfully collected from women were: urine, 92.5 to 95.7%; hair, 89.6 to 92.5%; vaginal swab, 84.2 to 88.5%; blood, 74.9 to 78.5%; 2-day saliva, 65.8 to 81.6%; and nails, 76.4 to 76.7%. For fathers, rates were highest for urine (94.9%) and lowest for hair (63.0%). CONCLUSION: High rates of consent for and collection of a wide variety of biospecimens can be achieved in prospective epidemiologic cohort studies of pregnant women. Ease of sample collection may be a primary factor influencing successful biospecimen collection.
BACKGROUND: The National Children's Study (NCS) Vanguard Study began enrollment in January 2009 as an initial pilot study for a planned large-scale, longitudinal U.S. cohort study of the effect of environmental influences on child health and development, with biological and environmental sample collection conducted in seven locations from April 2009 to October 2010. We sought to determine rates of consent for, and success of collection of, maternal and paternal biospecimens before and during pregnancy in the NCS Vanguard Study. METHODS: Samples of blood, saliva, vaginal swabs, urine, hair, and nails were collected before and during pregnancy. All specimens were sent to a central repository for processing, storage, and quality assessment. RESULTS: Of 780 pregnant women asked to consent to sample collection, 773 (>99%) agreed, and of 295 nonpregnant women, 292 (99%) agreed. Of 440 fathers asked to consent to sample collection, 435 (99%) agreed. Frequency of successful collection of biospecimens varied depending on sample and visit type. In descending order, the ranges over all visit types of the proportion of expected samples successfully collected from women were: urine, 92.5 to 95.7%; hair, 89.6 to 92.5%; vaginal swab, 84.2 to 88.5%; blood, 74.9 to 78.5%; 2-day saliva, 65.8 to 81.6%; and nails, 76.4 to 76.7%. For fathers, rates were highest for urine (94.9%) and lowest for hair (63.0%). CONCLUSION: High rates of consent for and collection of a wide variety of biospecimens can be achieved in prospective epidemiologic cohort studies of pregnant women. Ease of sample collection may be a primary factor influencing successful biospecimen collection.
Authors: Kelly M Bakulski; HwaJin Lee; Jason I Feinberg; Ellen M Wells; Shannon Brown; Julie B Herbstman; Frank R Witter; Rolf U Halden; Kathleen Caldwell; Mary Ellen Mortensen; Andrew E Jaffe; John Moye; Laura E Caulfield; Yi Pan; Lynn R Goldman; Andrew P Feinberg; M Daniele Fallin Journal: Int J Epidemiol Date: 2015-04-22 Impact factor: 7.196
Authors: Linda Titus-Ernstoff; Rebecca Troisi; Elizabeth E Hatch; Marianne Hyer; Lauren A Wise; Julie R Palmer; Raymond Kaufman; Ervin Adam; Kenneth Noller; Arthur L Herbst; William Strohsnitter; Bernard F Cole; Patricia Hartge; Robert N Hoover Journal: Epidemiology Date: 2008-03 Impact factor: 4.822
Authors: Renate D Savich; Beth B Tigges; Lisbeth Iglesias Rios; Joanne McCloskey; Kristine Tollestrup; Robert D Annett Journal: J Community Genet Date: 2019-11-28
Authors: Elissa Z Faro; Katherine A Sauder; Amber L Anderson; Anne L Dunlop; Jean M Kerver; Monica McGrath; Mary Roary; Carolyn W Roman; Cara Weidinger; Kathi C Huddleston Journal: MCN Am J Matern Child Nurs Date: 2021 Jul-Aug 01 Impact factor: 1.753
Authors: Peter K Gilbertson; Susan Forrester; Linda Andrews; Kathleen McCann; Lydia Rogers; Christina Park; Jack Moye Journal: Front Public Health Date: 2021-03-05
Authors: Elizabeth Barksdale Boyle; Susan M Viet; David J Wright; Lori S Merrill; K Udeni Alwis; Benjamin C Blount; Mary E Mortensen; John Moye; Michael Dellarco Journal: Int J Environ Res Public Health Date: 2016-03-29 Impact factor: 3.390