Literature DB >> 26405152

Combination of Tmprss6- ASO and the iron chelator deferiprone improves erythropoiesis and reduces iron overload in a mouse model of beta-thalassemia intermedia.

Carla Casu1, Mariam Aghajan2, Paraskevi Rea Oikonomidou1, Shuling Guo2, Brett P Monia2, Stefano Rivella3.   

Abstract

Entities:  

Keywords:  chelator; erythropoiesis; iron metabolism; iron overload; red blood cells

Mesh：

Substances：

Year:  2015        PMID： 26405152      PMCID： PMC4697899          DOI： 10.3324/haematol.2015.133348

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


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  12 in total

1.  Decreased hepcidin expression in murine β-thalassemia is associated with suppression of Bmp/Smad signaling.

Authors:  Nermi L Parrow; Sara Gardenghi; Pedro Ramos; Carla Casu; Robert W Grady; Erik R Anderson; Yatrik M Shah; Huihui Li; Yelena Z Ginzburg; Robert E Fleming; Stefano Rivella
Journal:  Blood       Date:  2012-03-29       Impact factor: 22.113

2.  mRNA expression of iron regulatory genes in beta-thalassemia intermedia and beta-thalassemia major mouse models.

Authors:  Orly Weizer-Stern; Konstantin Adamsky; Ninette Amariglio; Eliezer Rachmilewitz; Laura Breda; Stefano Rivella; Gideon Rechavi
Journal:  Am J Hematol       Date:  2006-07       Impact factor: 10.047

3.  Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia.

Authors:  Ilaria V Libani; Ella C Guy; Luca Melchiori; Raffaella Schiro; Pedro Ramos; Laura Breda; Thomas Scholzen; Amy Chadburn; YiFang Liu; Margrit Kernbach; Bettina Baron-Lühr; Matteo Porotto; Maria de Sousa; Eliezer A Rachmilewitz; John D Hood; M Domenica Cappellini; Patricia J Giardina; Robert W Grady; Johannes Gerdes; Stefano Rivella
Journal:  Blood       Date:  2008-05-14       Impact factor: 22.113

Review 4.  β-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism.

Authors:  Yelena Ginzburg; Stefano Rivella
Journal:  Blood       Date:  2011-07-18       Impact factor: 22.113

5.  Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera.

Authors:  Orly Weizer-Stern; Konstantin Adamsky; Ninette Amariglio; Carina Levin; Ariel Koren; William Breuer; Eliezer Rachmilewitz; Laura Breda; Stefano Rivella; Z Ioav Cabantchik; Gideon Rechavi
Journal:  Br J Haematol       Date:  2006-08-25       Impact factor: 6.998

Review 6.  The role of ineffective erythropoiesis in non-transfusion-dependent thalassemia.

Authors:  Stefano Rivella
Journal:  Blood Rev       Date:  2012-04       Impact factor: 8.250

7.  Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin.

Authors:  Sara Gardenghi; Maria F Marongiu; Pedro Ramos; Ella Guy; Laura Breda; Amy Chadburn; YiFang Liu; Ninette Amariglio; Gideon Rechavi; Eliezer A Rachmilewitz; William Breuer; Z Ioav Cabantchik; Diedra M Wrighting; Nancy C Andrews; Maria de Sousa; Patricia J Giardina; Robert W Grady; Stefano Rivella
Journal:  Blood       Date:  2007-02-13       Impact factor: 22.113

8.  An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia.

Authors:  Paul J Schmidt; Iva Toudjarska; Anoop K Sendamarai; Tim Racie; Stuart Milstein; Brian R Bettencourt; Julia Hettinger; David Bumcrot; Mark D Fleming
Journal:  Blood       Date:  2012-12-06       Impact factor: 22.113

9.  Redistribution of accumulated cell iron: a modality of chelation with therapeutic implications.

Authors:  Yang-Sung Sohn; William Breuer; Arnold Munnich; Z Ioav Cabantchik
Journal:  Blood       Date:  2007-11-01       Impact factor: 22.113

10.  Combination therapy with a Tmprss6 RNAi-therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of β-thalassemia intermedia.

Authors:  Paul J Schmidt; Tim Racie; Mark Westerman; Kevin Fitzgerald; James S Butler; Mark D Fleming
Journal:  Am J Hematol       Date:  2015-04       Impact factor: 10.047
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  35 in total

1.  Correcting β-thalassemia by combined therapies that restrict iron and modulate erythropoietin activity.

Authors:  Carla Casu; Mariateresa Pettinato; Alison Liu; Mariam Aghajan; Vania Lo Presti; Maria Rosa Lidonnici; Kevin A Munoz; Emir O'Hara; Violante Olivari; Simona Maria Di Modica; Sheri Booten; Shuling Guo; Garry Neil; Reem Miari; Nir Shapir; Inbal Zafir-Lavie; Hagit Domev; Giuliana Ferrari; Despina Sitara; Antonella Nai; Stefano Rivella
Journal:  Blood       Date:  2020-10-22       Impact factor: 22.113

Review 2.  New strategies to target iron metabolism for the treatment of beta thalassemia.

Authors:  Paraskevi Rea Oikonomidou; Carla Casu; Stefano Rivella
Journal:  Ann N Y Acad Sci       Date:  2016-02-25       Impact factor: 5.691

Review 3.  Iron metabolism under conditions of ineffective erythropoiesis in β-thalassemia.

Authors:  Stefano Rivella
Journal:  Blood       Date:  2018-11-06       Impact factor: 22.113

4.  Decreasing TfR1 expression reverses anemia and hepcidin suppression in β-thalassemic mice.

Authors:  Huihui Li; Tenzin Choesang; Weili Bao; Huiyong Chen; Maria Feola; Daniel Garcia-Santos; Jie Li; Shuming Sun; Antonia Follenzi; Petra Pham; Jing Liu; Jinghua Zhang; Prem Ponka; Xiuli An; Narla Mohandas; Robert E Fleming; Stefano Rivella; Guiyuan Li; Yelena Z Ginzburg
Journal:  Blood       Date:  2017-02-01       Impact factor: 22.113

Review 5.  β-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies.

Authors:  Stefano Rivella
Journal:  Haematologica       Date:  2015-04       Impact factor: 9.941

6.  Cutting not the key to TMPRSS6 activity?

Authors:  Thomas Benedict Bartnikas
Journal:  Blood       Date:  2020-08-20       Impact factor: 22.113

7.  New potential players in hepcidin regulation.

Authors:  Maxwell Chappell; Stefano Rivella
Journal:  Haematologica       Date:  2019-09       Impact factor: 9.941

Review 8.  Hepcidin agonists as therapeutic tools.

Authors:  Carla Casu; Elizabeta Nemeth; Stefano Rivella
Journal:  Blood       Date:  2018-03-09       Impact factor: 22.113

9.  Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera.

Authors:  Carla Casu; Paraskevi Rea Oikonomidou; Huiyong Chen; Vijay Nandi; Yelena Ginzburg; Princy Prasad; Robert E Fleming; Yatrik M Shah; Erika V Valore; Elizabeta Nemeth; Tomas Ganz; Brian MacDonald; Stefano Rivella
Journal:  Blood       Date:  2016-05-06       Impact factor: 22.113

Review 10.  Ineffective Erythropoiesis: Anemia and Iron Overload.

Authors:  Ritama Gupta; Khaled M Musallam; Ali T Taher; Stefano Rivella
Journal:  Hematol Oncol Clin North Am       Date:  2017-12-29       Impact factor: 3.722
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