| Literature DB >> 26403244 |
Eduard Kejnovsky1, Viktor Tokan2, Matej Lexa3.
Abstract
A significant part of eukaryotic genomes is formed by transposable elements (TEs) containing not only genes but also regulatory sequences. Some of the regulatory sequences located within TEs can form secondary structures like hairpins or three-stranded (triplex DNA) and four-stranded (quadruplex DNA) conformations. This review focuses on recent evidence showing that G-quadruplex-forming sequences in particular are often present in specific parts of TEs in plants and humans. We discuss the potential role of these structures in the TE life cycle as well as the impact of G-quadruplexes on replication, transcription, translation, chromatin status, and recombination. The aim of this review is to emphasize that TEs may serve as vehicles for the genomic spread of G-quadruplexes. These non-canonical DNA structures and their conformational switches may constitute another regulatory system that, together with small and long non-coding RNA molecules and proteins, contribute to the complex cellular network resulting in the large diversity of eukaryotes.Entities:
Keywords: DNA and RNA quadruplexes; G-quadruplexes; LTR retrotransposons; recombination; replication; transcription; transposable elements
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Year: 2015 PMID： 26403244 DOI： 10.1007/s10577-015-9491-7
Source DB: PubMed Journal: Chromosome Res ISSN： 0967-3849 Impact factor: 5.239