Miharu Samuraki1, Ichiro Matsunari2,3, Mitsuhiro Yoshita1,4, Keisuke Shima1, Moeko Noguchi-Shinohara1, Tsuyoshi Hamaguchi1, Kenjiro Ono1, Masahito Yamada1. 1. Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa, Japan. 2. Clinical Research Department, the Medical and Pharmacological Research Center Foundation, Hakui, Ishikawa, Japan. 3. Division of Nuclear Medicine, Department of Radiology, Saitama Medical University Hospital, Iruma, Saitama, Japan. 4. Dementia Medical Center, Department of Neurology, and Institute for Clinical Research, National Hospital Organization Hokuriku Hospital, Nanto, Toyama, Japan.
Abstract
BACKGROUND: Microbleeds (MBs) are frequently observed in Alzheimer's disease (AD); however, the relevance to AD pathophysiology has not been elucidated. OBJECTIVES: We investigated correlation of MBs, especially cerebral amyloid angiopathy (CAA)-related MBs with cognitive function, gray matter volume, and glucose metabolism in AD. METHODS: We performed magnetic resonance imaging including T2*-weighted imaging sequence for 206 patients with AD. Among them, 158 AD patients with no focal brain lesions except for MBs were investigated with cognitive tests, voxel-based morphometry, and 18F-fluorodeoxyglucose positron emission tomography in a cross-sectional observational study. RESULTS: Of the 158 patients with no hemorrhagic and/or ischemic stroke lesions except for MBs, 27 patients had MBs, in which 17 patients showed CAA-related MBs that located only in cortex/subcortex (CAA-related MBs), and 10 patients showed CAA-unrelated MBs that located in deep regions regardless of the presence of MBs in cortical/subcortical regions. There were slightly but significant differences in cognitive functions between the patients without MBs, those with CAA-related MBs, and those with CAA-unrelated MBs. MBs were recognized frequently in the occipital lobe in the patients with CAA-related MBs. The patients with CAA-related MBs showed gray matter atrophy in the temporal lobe and cerebellum, and glucose hypometabolism in the temporal lobe compared with those without MBs. CONCLUSIONS: Our results indicate that MBs, particularly CAA-related MBs would cause gray matter atrophy and glucose hypometabolism in AD.
BACKGROUND: Microbleeds (MBs) are frequently observed in Alzheimer's disease (AD); however, the relevance to AD pathophysiology has not been elucidated. OBJECTIVES: We investigated correlation of MBs, especially cerebral amyloid angiopathy (CAA)-related MBs with cognitive function, gray matter volume, and glucose metabolism in AD. METHODS: We performed magnetic resonance imaging including T2*-weighted imaging sequence for 206 patients with AD. Among them, 158 ADpatients with no focal brain lesions except for MBs were investigated with cognitive tests, voxel-based morphometry, and 18F-fluorodeoxyglucose positron emission tomography in a cross-sectional observational study. RESULTS: Of the 158 patients with no hemorrhagic and/or ischemic stroke lesions except for MBs, 27 patients had MBs, in which 17 patients showed CAA-related MBs that located only in cortex/subcortex (CAA-related MBs), and 10 patients showed CAA-unrelated MBs that located in deep regions regardless of the presence of MBs in cortical/subcortical regions. There were slightly but significant differences in cognitive functions between the patients without MBs, those with CAA-related MBs, and those with CAA-unrelated MBs. MBs were recognized frequently in the occipital lobe in the patients with CAA-related MBs. The patients with CAA-related MBs showed gray matter atrophy in the temporal lobe and cerebellum, and glucose hypometabolism in the temporal lobe compared with those without MBs. CONCLUSIONS: Our results indicate that MBs, particularly CAA-related MBs would cause gray matter atrophy and glucose hypometabolism in AD.
Authors: Yael D Reijmer; Panagiotis Fotiadis; Andreas Charidimou; Susanne J van Veluw; Li Xiong; Grace A Riley; Sergi Martinez-Ramirez; Kristin Schwab; Anand Viswanathan; M Edip Gurol; Steven M Greenberg Journal: Hum Brain Mapp Date: 2017-04-30 Impact factor: 5.038
Authors: Panagiotis Fotiadis; Sanneke van Rooden; Jeroen van der Grond; Aaron Schultz; Sergi Martinez-Ramirez; Eitan Auriel; Yael Reijmer; Anna M van Opstal; Alison Ayres; Kristin M Schwab; Trey Hedden; Jonathan Rosand; Anand Viswanathan; Marieke Wermer; Gisela Terwindt; Reisa A Sperling; Jonathan R Polimeni; Keith A Johnson; Mark A van Buchem; Steven M Greenberg; M Edip Gurol Journal: Lancet Neurol Date: 2016-05-11 Impact factor: 44.182