Wei Feng1, Jennifer S Yokoyama2, Shunying Yu3, You Chen4, Yan Cheng1, Luke W Bonham2, Dongxiang Wang3, Yuan Shen5, Wenyuan Wu1, Chunbo Li3. 1. Department of Psychiatry, Tongji Hospital, Tongji University, Shanghai, P.R. China. 2. Memory and Aging Center, Department of Neurology, University of California, San Francisco, California, USA. 3. Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China. 4. Shanghai Yangpu District Mental Health Center, Shanghai, P.R. China. 5. Department of Psychiatry, Tenth People's Hospital of Tongji University, Shanghai, P.R. China.
Abstract
BACKGROUND:Cognitive training may contribute to the ability to maintain cognitive function in healthy elderly adults. Whether genotype modifies training effects remains unknown. OBJECTIVE: Assess influence of APOE on cognitive function over time in community-dwelling elderly adults participating in multi-domain cognitive training. METHODS:Healthy individuals ≥70 years of age were screened from one urban community in Shanghai. 145 healthy Chinese older adults met inclusion criteria and were assigned to intervention (n = 88) or control (n = 57) groups. Multi-domain cognitive training involved 24 sessions of different content taking place over 12 weeks. Neuropsychological testing was administered at baseline, immediately after training, six months and twelve months post-intervention; composite measures of cognitive function were identified via factor analysis. RESULTS: Three factors explained the majority of variance in function (verbal memory, processing speed, executive function). The intervention attenuated 12-month declines in processing speed, regardless of APOE genotype (p = 0.047). Executive function declined in APOEɛ4 carriers over 12 months, regardless of intervention (p = 0.056). There was a significant interaction after 12 months where intervention ɛ4 carriers had better processing speed than ɛ4 controls (p = 0.003). Intervention ɛ2 carriers had better executive function immediately after training (p = 0.02) and had better verbal memory 6-months post-intervention (p = 0.04). These effects remained significant after false-discovery rate correction. CONCLUSION:Multi-domain cognitive training reduces declines in processing speed over time. APOEɛ4 is associated with reductions in executive function over time, and training may attenuate ɛ4-associated declines in processing speed. APOEɛ2 carriers may also benefit from training, particularly on measures of executive function and verbal memory.
RCT Entities:
BACKGROUND: Cognitive training may contribute to the ability to maintain cognitive function in healthy elderly adults. Whether genotype modifies training effects remains unknown. OBJECTIVE: Assess influence of APOE on cognitive function over time in community-dwelling elderly adults participating in multi-domain cognitive training. METHODS: Healthy individuals ≥70 years of age were screened from one urban community in Shanghai. 145 healthy Chinese older adults met inclusion criteria and were assigned to intervention (n = 88) or control (n = 57) groups. Multi-domain cognitive training involved 24 sessions of different content taking place over 12 weeks. Neuropsychological testing was administered at baseline, immediately after training, six months and twelve months post-intervention; composite measures of cognitive function were identified via factor analysis. RESULTS: Three factors explained the majority of variance in function (verbal memory, processing speed, executive function). The intervention attenuated 12-month declines in processing speed, regardless of APOE genotype (p = 0.047). Executive function declined in APOEɛ4 carriers over 12 months, regardless of intervention (p = 0.056). There was a significant interaction after 12 months where intervention ɛ4 carriers had better processing speed than ɛ4 controls (p = 0.003). Intervention ɛ2 carriers had better executive function immediately after training (p = 0.02) and had better verbal memory 6-months post-intervention (p = 0.04). These effects remained significant after false-discovery rate correction. CONCLUSION: Multi-domain cognitive training reduces declines in processing speed over time. APOEɛ4 is associated with reductions in executive function over time, and training may attenuate ɛ4-associated declines in processing speed. APOEɛ2 carriers may also benefit from training, particularly on measures of executive function and verbal memory.
Authors: Sherry L Willis; Sharon L Tennstedt; Michael Marsiske; Karlene Ball; Jeffrey Elias; Kathy Mann Koepke; John N Morris; George W Rebok; Frederick W Unverzagt; Anne M Stoddard; Elizabeth Wright Journal: JAMA Date: 2006-12-20 Impact factor: 56.272
Authors: R Katzman; M Y Zhang; P J Chen; N Gu; S Jiang; T Saitoh; X Chen; M Klauber; R G Thomas; W T Liu; E S Yu Journal: Neurology Date: 1997-09 Impact factor: 9.910
Authors: George W Rebok; Karlene Ball; Lin T Guey; Richard N Jones; Hae-Young Kim; Jonathan W King; Michael Marsiske; John N Morris; Sharon L Tennstedt; Frederick W Unverzagt; Sherry L Willis Journal: J Am Geriatr Soc Date: 2014-01-13 Impact factor: 5.562