Literature DB >> 26401033

Human Cytomegalovirus pUL93 Is Required for Viral Genome Cleavage and Packaging.

Bernadette M DeRussy1, Ritesh Tandon2.   

Abstract

Human cytomegalovirus (HCMV) pUL93 is essential for virus growth, but its precise function in the virus life cycle is unknown. Here, we characterize a UL93 stop mutant virus (UL93st-TB40/E-BAC) to demonstrate that the absence of this protein does not restrict viral gene expression; however, cleavage of viral DNA into unit-length genomes as well as genome packaging is abolished. Thus, pUL93 is required for viral genome cleavage and packaging.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26401033      PMCID： PMC4645300          DOI： 10.1128/JVI.02382-15

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  41 in total

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4.  The alpha sequence of the cytomegalovirus genome functions as a cleavage/packaging signal for herpes simplex virus defective genomes.

Authors:  R R Spaete; E S Mocarski
Journal:  J Virol       Date:  1985-06       Impact factor: 5.103

5.  Model for DNA packaging into bacteriophage T4 heads.

Authors:  L W Black; D J Silverman
Journal:  J Virol       Date:  1978-11       Impact factor: 5.103

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Authors:  U K Laemmli; M Favre
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Authors:  M A McVoy; S P Adler
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8.  In vitro activities of benzimidazole D- and L-ribonucleosides against herpesviruses.

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Journal:  Antimicrob Agents Chemother       Date:  2003-07       Impact factor: 5.191

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  9 in total

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3.  Human Cytomegalovirus pUL93 Links Nucleocapsid Maturation and Nuclear Egress.

Authors:  Bernadette M DeRussy; Molly T Boland; Ritesh Tandon
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4.  The Essential Human Cytomegalovirus Proteins pUL77 and pUL93 Are Structural Components Necessary for Viral Genome Encapsidation.

Authors:  Eva Maria Borst; Rudolf Bauerfeind; Anne Binz; Thomas Min Stephan; Sebastian Neuber; Karen Wagner; Lars Steinbrück; Beate Sodeik; Tihana Lenac Roviš; Stipan Jonjić; Martin Messerle
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Authors:  G Ligat; C Jacquet; S Chou; A Couvreux; S Alain; S Hantz
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Review 6.  The human cytomegalovirus terminase complex as an antiviral target: a close-up view.

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7.  Assembly of infectious Kaposi's sarcoma-associated herpesvirus progeny requires formation of a pORF19 pentamer.

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Journal:  PLoS Biol       Date:  2021-11-04       Impact factor: 8.029

8.  Effective screening of SARS-CoV-2 neutralizing antibodies in patient serum using lentivirus particles pseudotyped with SARS-CoV-2 spike glycoprotein.

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Review 9.  The Ins and Outs of Herpesviral Capsids: Divergent Structures and Assembly Mechanisms across the Three Subfamilies.

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  9 in total

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