Literature DB >> 26396094

HUS and the case for complement.

Edward M Conway1.   

Abstract

Hemolytic-uremic syndrome (HUS) is a thrombotic microangiopathy that is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and renal failure. Excess complement activation underlies atypical HUS and is evident in Shiga toxin-induced HUS (STEC-HUS). This Spotlight focuses on new knowledge of the role of Escherichia coli-derived toxins and polyphosphate in modulating complement and coagulation, and how they affect disease progression and response to treatment. Such new insights may impact on current and future choices of therapies for STEC-HUS.
© 2015 by The American Society of Hematology.

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Year:  2015        PMID： 26396094     DOI： 10.1182/blood-2015-03-569277

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  16 in total

1.  Complement Gene Variants and Shiga Toxin-Producing Escherichia coli-Associated Hemolytic Uremic Syndrome: Retrospective Genetic and Clinical Study.

Authors:  Véronique Frémeaux-Bacchi; Anne-Laure Sellier-Leclerc; Paula Vieira-Martins; Sophie Limou; Theresa Kwon; Annie Lahoche; Robert Novo; Brigitte Llanas; François Nobili; Gwenaëlle Roussey; Mathilde Cailliez; Tim Ulinski; Georges Deschênes; Corinne Alberti; François-Xavier Weill; Patricia Mariani; Chantal Loirat
Journal:  Clin J Am Soc Nephrol       Date:  2019-01-23       Impact factor: 8.237

2.  [Clinical course and differential diagnosis of thrombotic microangiopathy].

Authors:  M Guthoff; N Heyne
Journal:  Med Klin Intensivmed Notfmed       Date:  2016-07-12       Impact factor: 0.840

Review 3.  Is eculizumab efficacious in Shigatoxin-associated hemolytic uremic syndrome? A narrative review of current evidence.

Authors:  Werner Keenswijk; Ann Raes; Johan Vande Walle
Journal:  Eur J Pediatr       Date:  2017-12-29       Impact factor: 3.183

4.  A rare case of thrombotic microangiopathy triggered by acute pancreatitis.

Authors:  Kevin Singh; Ahmed Jamal Nadeem; Behzad Doratotaj
Journal:  BMJ Case Rep       Date:  2017-05-15

5.  Decreased severity of Shiga toxin-producing Escherichia coli haemolytic uraemic syndrome (STEC-HUS) in a child with type 1 von Willebrand disease.

Authors:  Matthew A Geramita; Johannes Hofer; James Cooper; Michael L Moritz
Journal:  BMJ Case Rep       Date:  2017-08-30

6.  Enterococcus raffinosus infection with atypical hemolytic uremic syndrome in a multiple myeloma patient after autologous stem cell transplant.

Authors:  Pankaj Mathur; Blake Hollowoa; Nupur Lala; Sharmilan Thanendrarajan; Aasiya Matin; Atul Kothari; Carolina Schinke
Journal:  Hematol Rep       Date:  2017-09-26

7.  Atypical Hemolytic Uremic Syndrome Secondary to Lupus Nephritis, Responsive to Eculizumab.

Authors:  Alexander G Raufi; Shruti Scott; Omar Darwish; Kevin Harley; Kanwarpal Kahlon; Sheetal Desai; Yuxin Lu; Minh-Ha Tran
Journal:  Hematol Rep       Date:  2016-09-30

8.  Haemolytic-uremic syndrome due to infection with adenovirus: A case report and literature review.

Authors:  Victoria Birlutiu; Rares Mircea Birlutiu
Journal:  Medicine (Baltimore)       Date:  2018-02       Impact factor: 1.817

Review 9.  Atypical Hemolytic Uremic Syndrome: A Brief Review.

Authors:  Kuixing Zhang; Yuxin Lu; Kevin T Harley; Minh-Ha Tran
Journal:  Hematol Rep       Date:  2017-06-01

10.  Cell Biological Responses after Shiga Toxin-1 Exposure to Primary Human Glomerular Microvascular Endothelial Cells from Pediatric and Adult Origin.

Authors:  Wouter J C Feitz; Petra A van Setten; Thea J A M van der Velden; Christoph Licht; Lambert P J W van den Heuvel; Nicole C A J van de Kar
Journal:  Int J Mol Sci       Date:  2021-05-25       Impact factor: 5.923
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