M Guthoff1, N Heyne2. 1. Medizinische Klinik IV, Abteilung für Endokrinologie und Diabetologie, Angiologie, Nephrologie und Klinische Chemie, Universitätsklinikum Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Deutschland. martina.guthoff@med.uni-tuebingen.de. 2. Medizinische Klinik IV, Abteilung für Endokrinologie und Diabetologie, Angiologie, Nephrologie und Klinische Chemie, Universitätsklinikum Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Deutschland.
Abstract
BACKGROUND: Thrombotic microangiopathies are complex diseases, requiring early differential diagnosis and targeted intervention. OBJECTIVES: Presentation of clinical phenotype and diagnostic algorithm, discussion of underlying pathophysiology, clinical management and therapy. METHODS: Summary of current knowledge from literature and expert opinion. RESULTS: Our understanding of pathophysiology and therapeutic options have changed substantially in recent years. Early differential diagnosis and targeted therapy are of prognostic relevance. CONCLUSIONS: A better understanding of underlying pathophysiology, increased clinical awareness and novel therapeutic options allow for a better prognosis of patients with thrombotic microangiopathy.
BACKGROUND:Thrombotic microangiopathies are complex diseases, requiring early differential diagnosis and targeted intervention. OBJECTIVES: Presentation of clinical phenotype and diagnostic algorithm, discussion of underlying pathophysiology, clinical management and therapy. METHODS: Summary of current knowledge from literature and expert opinion. RESULTS: Our understanding of pathophysiology and therapeutic options have changed substantially in recent years. Early differential diagnosis and targeted therapy are of prognostic relevance. CONCLUSIONS: A better understanding of underlying pathophysiology, increased clinical awareness and novel therapeutic options allow for a better prognosis of patients with thrombotic microangiopathy.
Authors: C M Legendre; C Licht; P Muus; L A Greenbaum; S Babu; C Bedrosian; C Bingham; D J Cohen; Y Delmas; K Douglas; F Eitner; T Feldkamp; D Fouque; R R Furman; O Gaber; M Herthelius; M Hourmant; D Karpman; Y Lebranchu; C Mariat; J Menne; B Moulin; J Nürnberger; M Ogawa; G Remuzzi; T Richard; R Sberro-Soussan; B Severino; N S Sheerin; A Trivelli; L B Zimmerhackl; T Goodship; C Loirat Journal: N Engl J Med Date: 2013-06-06 Impact factor: 91.245
Authors: Josep M Campistol; Manuel Arias; Gema Ariceta; Miguel Blasco; Mario Espinosa; Josep M Grinyó; Manuel Praga; Roser Torra; Ramón Vilalta; Santiago Rodríguez de Córdoba Journal: Nefrologia Date: 2013-01-18 Impact factor: 2.033
Authors: Jan Menne; Martin Nitschke; Robert Stingele; Mariam Abu-Tair; Jan Beneke; Jörn Bramstedt; Jan P Bremer; Reinhard Brunkhorst; Veit Busch; Reinhard Dengler; Günther Deuschl; Klaus Fellermann; Helmut Fickenscher; Christoph Gerigk; Alexander Goettsche; Jobst Greeve; Carsten Hafer; Friedrich Hagenmüller; Hermann Haller; Stefan Herget-Rosenthal; Bernd Hertenstein; Christina Hofmann; Melanie Lang; Jan T Kielstein; Ulrich C Klostermeier; Johannes Knobloch; Markus Kuehbacher; Ulrich Kunzendorf; Hendrik Lehnert; Michael P Manns; Tobias F Menne; Tobias N Meyer; Claus Michael; Thomas Münte; Christine Neumann-Grutzeck; Jens Nuernberger; Hermann Pavenstaedt; Leyla Ramazan; Lutz Renders; Jonas Repenthin; Wolfgang Ries; Axel Rohr; Lars Christian Rump; Ola Samuelsson; Friedhelm Sayk; Bernhard M W Schmidt; Sabine Schnatter; Harald Schöcklmann; Stefan Schreiber; Cay U von Seydewitz; Jürgen Steinhoff; Sylvia Stracke; Sebastian Suerbaum; Andreas van de Loo; Martin Vischedyk; Karin Weissenborn; Peter Wellhöner; Monika Wiesner; Sebastian Zeissig; Jürgen Büning; Mario Schiffer; Tanja Kuehbacher Journal: BMJ Date: 2012-07-19
Authors: Christoph Licht; Larry A Greenbaum; Petra Muus; Sunil Babu; Camille L Bedrosian; David J Cohen; Yahsou Delmas; Kenneth Douglas; Richard R Furman; Osama A Gaber; Timothy Goodship; Maria Herthelius; Maryvonne Hourmant; Christophe M Legendre; Giuseppe Remuzzi; Neil Sheerin; Antonella Trivelli; Chantal Loirat Journal: Kidney Int Date: 2015-02-04 Impact factor: 10.612