| Literature DB >> 26390057 |
Norihiro Kato1, Marie Loh2,3,4, Fumihiko Takeuchi1, Niek Verweij5, Xu Wang6, Weihua Zhang3,7, Tanika N Kelly8, Danish Saleheen9,10,11, Benjamin Lehne3, Irene Mateo Leach5, Molly Scannell Bryan12, Yik-Ying Teo6,13,14,15,16,17, Jiang He8, Paul Elliott3, E Shyong Tai6,18,19, Pim van der Harst5,20,21, Jaspal S Kooner7,22,23, John C Chambers3,7,23, Alexander W Drong24, James Abbott25, Simone Wahl26,26,27, Sian-Tsung Tan7,22, William R Scott3,22, Gianluca Campanella3, Marc Chadeau-Hyam3, Uzma Afzal3,7, Tarunveer S Ahluwalia28,29,30, Marc Jan Bonder20, Peng Chen6, Abbas Dehghan31, Todd L Edwards32, Tõnu Esko33,34,35,36, Min Jin Go37, Sarah E Harris38,39, Jaana Hartiala40,41, Silva Kasela33, Anuradhani Kasturiratne42, Chiea-Chuen Khor6,13,43,44, Marcus E Kleber45, Huaixing Li46, Zuan Yu Mok47, Masahiro Nakatochi48, Nur Sabrina Sapari47, Richa Saxena49, Alexandre F R Stewart50,51, Lisette Stolk52, Yasuharu Tabara53, Ai Ling Teh54, Ying Wu55, Jer-Yuarn Wu56,57, Yi Zhang58,59, Imke Aits60, Alexessander Da Silva Couto Alves61, Shikta Das61, Rajkumar Dorajoo13, Jemma C Hopewell62, Yun Kyoung Kim37, Robert W Koivula63, Jian'an Luan64, Leo-Pekka Lyytikäinen65,66, Quang N Nguyen67, Mark A Pereira68, Iris Postmus69,70, Olli T Raitakari71,72, Robert A Scott64, Rossella Sorice73, Vinicius Tragante74, Michela Traglia75,76, Jon White77, Ken Yamamoto78, Yonghong Zhang79, Linda S Adair80, Alauddin Ahmed81, Koichi Akiyama1, Rasheed Asif9, Tin Aung14, Inês Barroso82,83,84, Andrew Bjonnes49, Timothy R Braun85, Hui Cai86,87, Li-Ching Chang56, Chien-Hsiun Chen56,57, Ching-Yu Cheng6,43,14,88, Yap-Seng Chong54,89, Rory Collins62, Regina Courtney86,87, Gail Davies39,90, Graciela Delgado45, Loi D Do67, Pieter A Doevendans74, Ron T Gansevoort91, Yu-Tang Gao92, Tanja B Grammer45, Niels Grarup28, Jagvir Grewal3,7, Dongfeng Gu93, Gurpreet S Wander94, Anna-Liisa Hartikainen95,96,97, Stanley L Hazen98,99, Jing He100, Chew-Kiat Heng101, James E Hixson102, Albert Hofman31, Chris Hsu103, Wei Huang104, Lise L N Husemoen105, Joo-Yeon Hwang37, Sahoko Ichihara106, Michiya Igase107, Masato Isono1, Johanne M Justesen28, Tomohiro Katsuya18,108, Muhammad G Kibriya12, Young Jin Kim37, Miyako Kishimoto109, Woon-Puay Koh6,110, Katsuhiko Kohara107, Meena Kumari111, Kenneth Kwek112, Nanette R Lee113,114, Jeannette Lee6, Jiemin Liao43,14, Wolfgang Lieb60, David C M Liewald39,90, Tatsuaki Matsubara115, Yumi Matsushita109, Thomas Meitinger116,117, Evelin Mihailov33, Lili Milani33, Rebecca Mills7, Nina Mononen65,66, Martina Müller-Nurasyid118,119,120, Toru Nabika121, Eitaro Nakashima122,123, Hong Kiat Ng47, Kjell Nikus124, Teresa Nutile73, Takayoshi Ohkubo125, Keizo Ohnaka126, Sarah Parish62, Lavinia Paternoster127, Hao Peng79, Annette Peters128,120, Son T Pham67, Mohitha J Pinidiyapathirage42, Mahfuzar Rahman81,129, Hiromi Rakugi108, Olov Rolandsson130, Michelle Ann Rozario47, Daniela Ruggiero73, Cinzia F Sala75, Ralhan Sarju94, Kazuro Shimokawa1, Harold Snieder131, Thomas Sparsø28, Wilko Spiering132, John M Starr39,133, David J Stott134, Daniel O Stram103, Takao Sugiyama135, Silke Szymczak136, W H Wilson Tang98,137, Lin Tong12, Stella Trompet138, Väinö Turjanmaa139,140, Hirotsugu Ueshima141,142, André G Uitterlinden31,52, Satoshi Umemura143, Marja Vaarasmaki95,96,97, Rob M van Dam6, Wiek H van Gilst5, Dirk J van Veldhuisen5, Jorma S Viikari144,145, Melanie Waldenberger26,128, Yiqin Wang46, Aili Wang79, Rory Wilson26,128, Tien-Yin Wong43,14, Yong-Bing Xiang92, Shuhei Yamaguchi146, Xingwang Ye46, Robin D Young10, Terri L Young147,148, Jian-Min Yuan149, Xueya Zhou150,151,152, Folkert W Asselbergs74,21,153, Marina Ciullo73, Robert Clarke62, Panos Deloukas154,155, Andre Franke136, Paul W Franks63,130,156, Steve Franks157, Yechiel Friedlander158, Myron D Gross159, Zhirong Guo79, Torben Hansen28, Marjo-Riitta Jarvelin2,61,97,160,161, Torben Jørgensen105, J Wouter Jukema138,21,162, Mika Kähönen139,140, Hiroshi Kajio109, Mika Kivimaki111, Jong-Young Lee163,164, Terho Lehtimäki65,66, Allan Linneberg105,165,166, Tetsuro Miki107, Oluf Pedersen28, Nilesh J Samani167,168, Thorkild I A Sørensen28,127,169, Ryoichi Takayanagi170, Daniela Toniolo75,171, Habibul Ahsan12, Hooman Allayee40,41, Yuan-Tsong Chen56, John Danesh10,172, Ian J Deary39,90, Oscar H Franco31, Lude Franke20, Bastiaan T Heijman173, Joanna D Holbrook54, Aaron Isaacs31, Bong-Jo Kim37, Xu Lin46, Jianjun Liu6,13, Winfried März45,174,175, Andres Metspalu33, Karen L Mohlke55, Dharambir K Sanghera85, Xiao-Ou Shu86,87, Joyce B J van Meurs52, Eranga Vithana43,14,147, Ananda R Wickremasinghe42, Cisca Wijmenga20, Bruce H W Wolffenbuttel176, Mitsuhiro Yokota177, Wei Zheng86,87, Dingliang Zhu58,59, Paolo Vineis3, Soterios A Kyrtopoulos178, Jos C S Kleinjans179, Mark I McCarthy24,180, Richie Soong47,181, Christian Gieger26,128, James Scott22.
Abstract
We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10(-11) to 5.0 × 10(-21)). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10(-6)). Our results provide new evidence for the role of DNA methylation in blood pressure regulation.Entities:
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Year: 2015 PMID： 26390057 PMCID： PMC4719169 DOI： 10.1038/ng.3405
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330