Justin R Ryder1,2, Michael O'Connell3, Tyler A Bosch4, Lisa Chow4, Kyle D Rudser3, Donald R Dengel1,5, Claudia K Fox1, Julia Steinberger1, Aaron S Kelly1,4. 1. Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota. 2. Division of Epidemiology & Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota. 3. Division of Biostatistics, University of Minnesota School of Public Health, Minneapolis, Minnesota. 4. Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota. 5. School of Kinesiology, University of Minnesota, Minneapolis, Minnesota.
Abstract
BACKGROUND: We examined whether sympathetic nervous system activity influences hypertension status and systolic blood pressure (SBP) independent of adiposity in youth ranging from normal-weight to severe obesity. METHODS: We examined the association of heart rate variability (HRV) with hypertension status and SBP among youth (6-18 y old; n = 188; 103 female). Seated SBP was measured using an automated cuff. Prehypertension (SBP percentile ≥ 90th to <95th) and hypertension (SBP percentile ≥ 95th) were defined by age-, sex-, and height-norms. Autonomic nervous system activity was measured using HRV via SphygmoCor MM3 system and analyzed for time- and frequency-domains. Total body fat was measured via dual-energy X-ray absorptiometry. RESULTS: Logistic regression models demonstrated lower values in each time-domain HRV measure and larger low-frequency (LF):high-frequency (HF) ratio to be significantly associated with higher odds of being prehypertensive/hypertensive (11-47% higher odds) independent of total body fat (P < 0.05). In linear regression analysis, lower time-domain, but not frequency-domain, HRV measures were significantly associated with higher SBP independent of total body fat (P < 0.05). CONCLUSION: These data suggest that impaired cardiac autonomic nervous system function, at rest, is associated with higher odds of being prehypertensive/hypertensive and higher SBP which may be independent of adiposity in youth.
BACKGROUND: We examined whether sympathetic nervous system activity influences hypertension status and systolic blood pressure (SBP) independent of adiposity in youth ranging from normal-weight to severe obesity. METHODS: We examined the association of heart rate variability (HRV) with hypertension status and SBP among youth (6-18 y old; n = 188; 103 female). Seated SBP was measured using an automated cuff. Prehypertension (SBP percentile ≥ 90th to <95th) and hypertension (SBP percentile ≥ 95th) were defined by age-, sex-, and height-norms. Autonomic nervous system activity was measured using HRV via SphygmoCor MM3 system and analyzed for time- and frequency-domains. Total body fat was measured via dual-energy X-ray absorptiometry. RESULTS: Logistic regression models demonstrated lower values in each time-domain HRV measure and larger low-frequency (LF):high-frequency (HF) ratio to be significantly associated with higher odds of being prehypertensive/hypertensive (11-47% higher odds) independent of total body fat (P < 0.05). In linear regression analysis, lower time-domain, but not frequency-domain, HRV measures were significantly associated with higher SBP independent of total body fat (P < 0.05). CONCLUSION: These data suggest that impaired cardiac autonomic nervous system function, at rest, is associated with higher odds of being prehypertensive/hypertensive and higher SBP which may be independent of adiposity in youth.
Authors: Stefanie Hillebrand; Renée de Mutsert; Tim Christen; Arie C Maan; J Wouter Jukema; Hildo J Lamb; Albert de Roos; Frits R Rosendaal; Martin den Heijer; Cees A Swenne Journal: Obesity (Silver Spring) Date: 2014-02-18 Impact factor: 5.002
Authors: Aaron S Kelly; Sarah E Barlow; Goutham Rao; Thomas H Inge; Laura L Hayman; Julia Steinberger; Elaine M Urbina; Linda J Ewing; Stephen R Daniels Journal: Circulation Date: 2013-09-09 Impact factor: 29.690
Authors: Franco Rabbia; Bernard Silke; Andrea Conterno; Tiziana Grosso; Barbara De Vito; Ivana Rabbone; Livio Chiandussi; Franco Veglio Journal: Obes Res Date: 2003-04
Authors: Aaron S Kelly; Kyle D Rudser; Donald R Dengel; Christopher L Kaufman; Michael I Reiff; Anne L Norris; Andrea M Metzig; Julia Steinberger Journal: J Pediatr Date: 2014-07-09 Impact factor: 4.406
Authors: Oliver Monfredi; Alexey E Lyashkov; Anne-Berit Johnsen; Shin Inada; Heiko Schneider; Ruoxi Wang; Mahesh Nirmalan; Ulrik Wisloff; Victor A Maltsev; Edward G Lakatta; Henggui Zhang; Mark R Boyett Journal: Hypertension Date: 2014-09-15 Impact factor: 10.190
Authors: Amy C Gross; Alexander M Kaizer; Justin R Ryder; Claudia K Fox; Kyle D Rudser; Donald R Dengel; Aaron S Kelly Journal: J Pediatr Date: 2018-05-10 Impact factor: 4.406
Authors: Brie M Reid; Michelle M Harbin; Jessica L Arend; Aaron S Kelly; Donald R Dengel; Megan R Gunnar Journal: J Pediatr Date: 2018-08-23 Impact factor: 4.406
Authors: Katelyn E Uithoven; Justin R Ryder; Roland Brown; Kyle D Rudser; Nicholas G Evanoff; Donald R Dengel; Aaron S Kelly Journal: J Vasc Diagn Interv Date: 2017-01-13
Authors: Patricia A Nixon; Lisa K Washburn; Thomas Michael O'Shea; Hossam A Shaltout; Gregory B Russell; Beverly M Snively; James C Rose Journal: Pediatr Res Date: 2016-09-15 Impact factor: 3.756
Authors: Bruna Cruz Magalhães; Nivaldo de Jesus Silva Soares Júnior; Carlos Alberto Alves Dias Filho; Rafael Martins Andrade; Carlos José Moraes Dias; Silvana de Figueredo Alencar de Oliveira; Luanda Sinthia Oliveira Silva Santana; Carlan da Silva Sena; Janaína de Oliveira Monzani-Brito; Andressa Coelho Ferreira; Cristiano Teixeira Mostarda Journal: Sleep Sci Date: 2020 Oct-Dec