Literature DB >> 26385090

Epileptogenesis.

Asla Pitkänen1, Katarzyna Lukasiuk2, F Edward Dudek3, Kevin J Staley4.   

Abstract

Epileptogenesis is a chronic process that can be triggered by genetic or acquired factors, and that can continue long after epilepsy diagnosis. In 2015, epileptogenesis is not a treatment indication, and there are no therapies available in clinic to treat individuals at risk of epileptogenesis. However, thanks to active research, a large number of animal models have become available for search of molecular mechanisms of epileptogenesis. The first glimpses of treatment targets and biomarkers that could be developed to become useful in clinic are in sight. However, the heterogeneity of the epilepsy condition, and the dynamics of molecular changes over the course of epileptogenesis remain as challenges to overcome.
Copyright © 2015 Cold Spring Harbor Laboratory Press; all rights reserved.

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Year:  2015        PMID： 26385090      PMCID： PMC4588129          DOI： 10.1101/cshperspect.a022822

Source DB:  PubMed          Journal:  Cold Spring Harb Perspect Med        ISSN： 2157-1422            Impact factor:   6.915


  123 in total

Review 1.  Epilepsy biomarkers.

Authors:  Jerome Engel; Asla Pitkänen; Jeffrey A Loeb; F Edward Dudek; Edward H Bertram; Andrew J Cole; Solomon L Moshé; Samuel Wiebe; Frances E Jensen; Istvan Mody; Astrid Nehlig; Annamaria Vezzani
Journal:  Epilepsia       Date:  2013-08       Impact factor: 5.864

2.  Proteomic profiling of the epileptic dentate gyrus.

Authors:  Aiqing Li; Yun-Sik Choi; Heather Dziema; Ruifeng Cao; Hee-Yeon Cho; Yeon Joo Jung; Karl Obrietan
Journal:  Brain Pathol       Date:  2010-07-04       Impact factor: 6.508

3.  Continuous electroencephalographic monitoring with radio-telemetry in a rat model of perinatal hypoxia-ischemia reveals progressive post-stroke epilepsy.

Authors:  Shilpa D Kadam; Andrew M White; Kevin J Staley; F Edward Dudek
Journal:  J Neurosci       Date:  2010-01-06       Impact factor: 6.167

4.  Whole transcriptome analysis of the hippocampus: toward a molecular portrait of epileptogenesis.

Authors:  Oswaldo K Okamoto; Luciana Janjoppi; Felipe M Bonone; Aline P Pansani; Alexandre V da Silva; Fúlvio A Scorza; Esper A Cavalheiro
Journal:  BMC Genomics       Date:  2010-04-08       Impact factor: 3.969

5.  Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy.

Authors:  Asla Pitkänen; Jari Nissinen; Jaak Nairismägi; Katarzyna Lukasiuk; Olli H J Gröhn; Riitta Miettinen; Risto Kauppinen
Journal:  Prog Brain Res       Date:  2002       Impact factor: 2.453

6.  The role of transcription factors cyclic-AMP responsive element modulator (CREM) and inducible cyclic-AMP early repressor (ICER) in epileptogenesis.

Authors:  B E Porter; I V Lund; F P Varodayan; R W Wallace; J A Blendy
Journal:  Neuroscience       Date:  2008-01-17       Impact factor: 3.590

7.  EEG spike activity precedes epilepsy after kainate-induced status epilepticus.

Authors:  Andrew White; Philip A Williams; Jennifer L Hellier; Suzanne Clark; F Edward Dudek; Kevin J Staley
Journal:  Epilepsia       Date:  2009-10-20       Impact factor: 5.864

8.  Risk of unprovoked seizure after acute symptomatic seizure: effect of status epilepticus.

Authors:  D C Hesdorffer; G Logroscino; G Cascino; J F Annegers; W A Hauser
Journal:  Ann Neurol       Date:  1998-12       Impact factor: 10.422

9.  Post-stroke epilepsy in young adults: a long-term follow-up study.

Authors:  Renate Arntz; Loes Rutten-Jacobs; Noortje Maaijwee; Hennie Schoonderwaldt; Lucille Dorresteijn; Ewoud van Dijk; Frank-Erik de Leeuw
Journal:  PLoS One       Date:  2013-02-04       Impact factor: 3.240

10.  Alterations in miRNA levels in the dentate gyrus in epileptic rats.

Authors:  Anna Maria Bot; Konrad Józef Dębski; Katarzyna Lukasiuk
Journal:  PLoS One       Date:  2013-10-11       Impact factor: 3.240
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  72 in total

Review 1.  Seizures and epilepsy: an overview for neuroscientists.

Authors:  Carl E Stafstrom; Lionel Carmant
Journal:  Cold Spring Harb Perspect Med       Date:  2015-06-01       Impact factor: 6.915

2.  Epilepsy-on-a-Chip System for Antiepileptic Drug Discovery.

Authors:  Jing Liu; Anna R Sternberg; Shabnam Ghiasvand; Yevgeny Berdichevsky
Journal:  IEEE Trans Biomed Eng       Date:  2018-09-19       Impact factor: 4.538

3.  Theta is the New Alpha.

Authors:  Libor Velíšek
Journal:  Epilepsy Curr       Date:  2017 Sep-Oct       Impact factor: 7.500

Review 4.  Glial source of nitric oxide in epileptogenesis: A target for disease modification in epilepsy.

Authors:  Shaunik Sharma; Sreekanth Puttachary; Thimmasettappa Thippeswamy
Journal:  J Neurosci Res       Date:  2017-12-12       Impact factor: 4.164

5.  Altered sleep homeostasis correlates with cognitive impairment in patients with focal epilepsy.

Authors:  Melanie Boly; Benjamin Jones; Graham Findlay; Erin Plumley; Armand Mensen; Bruce Hermann; Guilio Tononi; Rama Maganti
Journal:  Brain       Date:  2017-04-01       Impact factor: 13.501

6.  The impact of postsynaptic density 95 blocking peptide (Tat-NR2B9c) and an iNOS inhibitor (1400W) on proteomic profile of the hippocampus in C57BL/6J mouse model of kainate-induced epileptogenesis.

Authors:  Karen Tse; Dean Hammond; Deborah Simpson; Robert J Beynon; Edward Beamer; Michael Tymianski; Michael W Salter; Graeme J Sills; Thimmasettappa Thippeswamy
Journal:  J Neurosci Res       Date:  2019-05-15       Impact factor: 4.164

Review 7.  Novel therapeutics for treating organophosphate-induced status epilepticus co-morbidities, based on changes in calcium homeostasis.

Authors:  Laxmikant S Deshpande; Robert J DeLorenzo
Journal:  Neurobiol Dis       Date:  2019-03-12       Impact factor: 5.996

8.  Calpain-dependent cleavage of GABAergic proteins during epileptogenesis.

Authors:  Marco I González
Journal:  Epilepsy Res       Date:  2019-09-17       Impact factor: 3.045

9.  Characterization of the Expression of the ATP-Gated P2X7 Receptor Following Status Epilepticus and during Epilepsy Using a P2X7-EGFP Reporter Mouse.

Authors:  James Morgan; Mariana Alves; Giorgia Conte; Aida Menéndez-Méndez; Laura de Diego-Garcia; Gioacchino de Leo; Edward Beamer; Jonathon Smith; Annette Nicke; Tobias Engel
Journal:  Neurosci Bull       Date:  2020-09-07       Impact factor: 5.203

10.  Protein Kinase A-Mediated Suppression of the Slow Afterhyperpolarizing KCa3.1 Current in Temporal Lobe Epilepsy.

Authors:  Manindra Nath Tiwari; Sandesh Mohan; Yoav Biala; Yoel Yaari
Journal:  J Neurosci       Date:  2019-10-31       Impact factor: 6.167
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