Darija Kisic-Tepavcevic1, Tatjana Pekmezovic1, Goran Trajkovic2, Nebojsa Stojsavljevic3, Irena Dujmovic3, Sarlota Mesaros3, Jelena Drulovic4. 1. Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia. 2. Institute of Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia. 3. Clinic of Neurology, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia. 4. Clinic of Neurology, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia. Electronic address: jelena60@eunet.rs.
Abstract
PURPOSE: Sexual dysfunction (SD) is a common but often overlooked and undertreated symptom in multiple sclerosis (MS). The purpose of our longitudinal study was to explore the changes in the level of sexual functioning in MS cohort after a period of 3 and 6 years of follow-up, as well as to investigate the predictors of changes in SD during the period of observation. METHODS: The study population comprise a cohort of 93 patients with MS (McDonald's criteria, 2001) who were assessed at three time points during the study (baseline, and at the 3- and 6-year follow-up). The presence and severity of SD was quantified by Szasz sexual functioning scale. Independent predictors of the ordinal-scaled measure of sexual problems were identified using a generalized linear mixed regression models. RESULTS: The number of reported SD symptoms increased markedly for both genders during the whole period of observation. Duration of follow-up, age, level of physical disability, depression and fatigue were identified as independent prognostic factors for deterioration of sexual functioning in patients with MS during the 6-year follow-up. CONCLUSION: Our study provides insight into dynamics of change in sexual function among patients with MS and predictors of change, over the period of 6 years.
PURPOSE:Sexual dysfunction (SD) is a common but often overlooked and undertreated symptom in multiple sclerosis (MS). The purpose of our longitudinal study was to explore the changes in the level of sexual functioning in MS cohort after a period of 3 and 6 years of follow-up, as well as to investigate the predictors of changes in SD during the period of observation. METHODS: The study population comprise a cohort of 93 patients with MS (McDonald's criteria, 2001) who were assessed at three time points during the study (baseline, and at the 3- and 6-year follow-up). The presence and severity of SD was quantified by Szasz sexual functioning scale. Independent predictors of the ordinal-scaled measure of sexual problems were identified using a generalized linear mixed regression models. RESULTS: The number of reported SD symptoms increased markedly for both genders during the whole period of observation. Duration of follow-up, age, level of physical disability, depression and fatigue were identified as independent prognostic factors for deterioration of sexual functioning in patients with MS during the 6-year follow-up. CONCLUSION: Our study provides insight into dynamics of change in sexual function among patients with MS and predictors of change, over the period of 6 years.
Authors: Scott D Newsome; Philip J Aliotta; Jacquelyn Bainbridge; Susan E Bennett; Gary Cutter; Kaylan Fenton; Fred Lublin; Dorothy Northrop; David Rintell; Bryan D Walker; Megan Weigel; Kathleen Zackowski; David E Jones Journal: Int J MS Care Date: 2017 Jan-Feb
Authors: Jana Pöttgen; Wim van de Vis; An van Nunen; Anita Rose; Jannie Engelbrecht; Michelle Pirard; Stephanie Lau; Christoph Heesen; Sascha Köpke Journal: Int J MS Care Date: 2020-12-28
Authors: Claudia H Marck; Pia L Jelinek; Tracey J Weiland; Jane S Hocking; Alysha M De Livera; Keryn L Taylor; Sandra L Neate; Naresh G Pereira; George A Jelinek Journal: BMC Neurol Date: 2016-11-04 Impact factor: 2.474