Literature DB >> 26384290

Design, synthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors.

Chao Zhang1, Shasha Li1, Liyan Ji1, Shan Liu1, Zhongjun Li1, Shuchun Li1, Xiangbao Meng2.   

Abstract

Three groups of non-camptothecin compounds with four to five fused rings have been designed and synthesized. Their in vitro anti-proliferative activity has been evaluated with five different cancer cell lines (HCT116, PC3, U87MG, HepG2, SK-OV-3). Compounds B-2 and B-3 showed the most potent cell growth inhibition with IC50 of 169 nM and 325 nM against U87MG cell line correspondingly.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Anti-cancer; Inhibitor; Synthesis; Topo I

Mesh：

Substances：

Year:  2015        PMID： 26384290     DOI： 10.1016/j.bmcl.2015.06.042

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Synthesis, biological evaluation, and molecular modeling of 11H-indeno[1,2-b]quinoxalin-11-one derivatives and tryptanthrin-6-oxime as c-Jun N-terminal kinase inhibitors.

Authors:  Igor A Schepetkin; Andrei I Khlebnikov; Andrei S Potapov; Anastasia R Kovrizhina; Vladislava V Matveevskaya; Maxim L Belyanin; Dmitriy N Atochin; Svitlana O Zanoza; Nadiya M Gaidarzhy; Sergiy A Lyakhov; Liliya N Kirpotina; Mark T Quinn
Journal:  Eur J Med Chem       Date:  2018-10-12       Impact factor: 6.514

2.  Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives and Analogs Targeting the NLRP3 Inflammasome.

Authors:  Liangkun Pan; Nan Hang; Chao Zhang; Yu Chen; Shuchun Li; Yang Sun; Zhongjun Li; Xiangbao Meng
Journal:  Molecules       Date:  2017-01-30       Impact factor: 4.411

3.  Arene-Ruthenium(II) Complexes Containing 11H-Indeno[1,2-b]quinoxalin-11-one Derivatives and Tryptanthrin-6-oxime: Synthesis, Characterization, Cytotoxicity, and Catalytic Transfer Hydrogenation of Aryl Ketones.

Authors:  Vladislava V Matveevskaya; Dmitry I Pavlov; Taisiya S Sukhikh; Artem L Gushchin; Alexander Yu Ivanov; Tatiana B Tennikova; Vladimir V Sharoyko; Sergey V Baykov; Enrico Benassi; Andrei S Potapov
Journal:  ACS Omega       Date:  2020-05-07

4.  A Chemo- and Regioselective Tandem [3 + 2]Heteroannulation Strategy for Carbazole Synthesis: Combining Two Mechanistically Distinct Bond-Forming Processes.

Authors:  Emma Campbell; Andrea Taladriz-Sender; Olivia I Paisley; Alan R Kennedy; Jacob T Bush; Glenn A Burley
Journal:  J Org Chem       Date:  2022-03-18       Impact factor: 4.354

Review 5.  DNA topoisomerases as molecular targets for anticancer drugs.

Authors:  Kamila Buzun; Anna Bielawska; Krzysztof Bielawski; Agnieszka Gornowicz
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051
  5 in total

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