Zhizhong Liu1, Guozhen Jin2, Yuzhen Qi3, Shoujie Shan4, Junjie Zhang4, Fei Ye4, Nailiang Tian4, Jiupei Chen4, Shaoliang Chen1. 1. Laboratory of Coronary Heart Diseases, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, Jiangsu Province, China ; Department of Cardiology, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, Jiangsu Province, China. 2. Laboratory of Coronary Heart Diseases, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, Jiangsu Province, China. 3. Department of Electrocardiology, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, Jiangsu Province, China. 4. Department of Cardiology, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, Jiangsu Province, China.
Abstract
OBJECTIVE: This study aimed to assess the long term outcomes (all-cause death, myocardial infarction, target vessel revascularization, and silent restenosis at 12 months) of one-stent vs. two-stent implantation due to coronary bifurcation lesionsin diabetic patients using AIR2 as a new endpoint. METHODS AND RESULTS: A total of 178 diabetic patients with true coronary bifurcation lesions underwent percutaneous coronary intervention in the DK-Crush trials. All patients were stratified based on the stent placement strategy: one-stent group (n=76) and two-stent group (n=102). Results showed the primary endpoint, AIR2, in one-stent group was twice that in two-stent group (32.9% vs. 16.7%, P=0.013). The incidence of silent restenosis at 12 months was also significantly higher in one-stent group (19.7% versus 4.9%, P=0.003). Moreover, Kaplan-Meier analysis revealed the cumulative AIR2-free survival rate after a 12-month follow-up was markedly lower in one-stent group than in two-stent group. Interestingly, MACEs, including death, myocardial infarction and repeat revascularization, were not comparable between 2 groups (13.2% vs. 12.7%, P=0.935). Likewise, the incidence of definite or probable ST in one-stent group was also similar to that in two-stent group (2.6% vs. 4.9%, P=0.761). CONCLUSION: Our study indicates that, in terms of the AIR2 as a combined clinical and angiographic endpoint, two-stent implantation is superior to one-stent implantation for the treatment of coronary bifurcation intervention in diabetic patients.
OBJECTIVE: This study aimed to assess the long term outcomes (all-cause death, myocardial infarction, target vessel revascularization, and silent restenosis at 12 months) of one-stent vs. two-stent implantation due to coronary bifurcation lesionsin diabeticpatients using AIR2 as a new endpoint. METHODS AND RESULTS: A total of 178 diabeticpatients with true coronary bifurcation lesions underwent percutaneous coronary intervention in the DK-Crush trials. All patients were stratified based on the stent placement strategy: one-stent group (n=76) and two-stent group (n=102). Results showed the primary endpoint, AIR2, in one-stent group was twice that in two-stent group (32.9% vs. 16.7%, P=0.013). The incidence of silent restenosis at 12 months was also significantly higher in one-stent group (19.7% versus 4.9%, P=0.003). Moreover, Kaplan-Meier analysis revealed the cumulative AIR2-free survival rate after a 12-month follow-up was markedly lower in one-stent group than in two-stent group. Interestingly, MACEs, including death, myocardial infarction and repeat revascularization, were not comparable between 2 groups (13.2% vs. 12.7%, P=0.935). Likewise, the incidence of definite or probable ST in one-stent group was also similar to that in two-stent group (2.6% vs. 4.9%, P=0.761). CONCLUSION: Our study indicates that, in terms of the AIR2 as a combined clinical and angiographic endpoint, two-stent implantation is superior to one-stent implantation for the treatment of coronary bifurcation intervention in diabeticpatients.
Authors: Lei Ge; Flavio Airoldi; Ioannis Iakovou; John Cosgrave; Iassen Michev; Giuseppe M Sangiorgi; Matteo Montorfano; Alaide Chieffo; Mauro Carlino; Nicola Corvaja; Antonio Colombo Journal: J Am Coll Cardiol Date: 2005-08-16 Impact factor: 24.094
Authors: J Al Suwaidi; P B Berger; C S Rihal; K N Garratt; M R Bell; H H Ting; J F Bresnahan; D E Grill; D R Holmes Journal: J Am Coll Cardiol Date: 2000-03-15 Impact factor: 24.094
Authors: Oladipupo Olafiranye; Helen Vlachos; Suresh R Mulukutla; Oscar C Marroquin; Faith Selzer; Sheryl F Kelsey; David O Williams; Patrick J Strollo; Steven E Reis; Joon S Lee; A J Conrad Smith Journal: Int J Cardiol Date: 2015-01-27 Impact factor: 4.164
Authors: Alexandre Abizaid; Marco A Costa; Didier Blanchard; Mariano Albertal; Hélèn Eltchaninoff; Giulio Guagliumi; Laarman Geert-Jan; Andrea S Abizaid; Amanda G M R Sousa; Egon Wuelfert; Lindeboom Wietze; J Eduardo Sousa; Patrick W Serruys; Marie-Claude Morice Journal: Eur Heart J Date: 2004-01 Impact factor: 29.983