Literature DB >> 26379995

Acute hepatitis induced by a Chinese herbal product Qibao Meiran Wan: a case study.

Xiaoyan Li1, Caihong Qu2, Qiong He3, Wenying Chen4, Xiaojuan Zhang4, Xiaoqi Liu4, Yuxing Liu2, Yongbo Tang5.   

Abstract

Qibao Meiran Wan is a Chinese herbal product sold as a therapy for tonifying the liver and kidney, dizziness, premature graying of hair, backache, constipation, and night sweats. It is widely available in Chinese pharmacies and drugstores and is sold without prescription. We describe a case of acute liver injury in a 26-year-old Chinese man who developed symptomatic hepatitis 1 month after starting Qibao Meiran Wan. There was no evidence of viral hepatitis, Epstein-Barr virus, cytomegalovirus, autoimmune hepatitis, or Budd-Chiari syndrome. The liver injury slowly resolved over 20 days after discontinuing the herbal product. Herbal toxicity was later confirmed by a liver biopsy. Qibao Meiran Wan contains a mixture of several plants including Polygonum multiflorum, which was previously associated with hepatotoxicity. To our knowledge, this is the first report of hepatotoxicity by Qibao Meiran Wan. Clinicians treating patients with acute hepatitis of unclear etiology should pay attention to the consumption of Qibao Meiran Wan.

Entities:  

Keywords:  Drug-induced liver injury; Qibao Meiran Wan; adverse drug reaction; hepatotoxicity

Year:  2015        PMID： 26379995      PMCID： PMC4565378     

Source DB:  PubMed          Journal:  Int J Clin Exp Med        ISSN： 1940-5901


  12 in total

1.  Acute hepatitis induced by Shou-Wu-Pian, a herbal product derived from Polygonum multiflorum.

Authors:  G J Park; S P Mann; M C Ngu
Journal:  J Gastroenterol Hepatol       Date:  2001-01       Impact factor: 4.029

2.  New case of acute hepatitis following the consumption of Shou Wu Pian, a Chinese herbal product derived from Polygonum multiflorum.

Authors:  Gabriela Mazzanti; Lucia Battinelli; Claudia Daniele; Claudio Maria Mastroianni; Miriam Lichtner; Simona Coletta; Sergio Costantini
Journal:  Ann Intern Med       Date:  2004-04-06       Impact factor: 25.391

3.  Use and safety perception of herbal remedies in patients with liver/biliary tract disorders: an Italian study.

Authors:  Massimo Marignani; Sara Gallina; Michela Di Fonzo; Ilaria Deli; Paola Begini; Elia Gigante; Marcella Epifani; Stefano Angeletti; Gianfranco Delle Fave
Journal:  J Clin Gastroenterol       Date:  2010-09       Impact factor: 3.062

4.  [Effects of exogenous phytohormones on hairy root growth and biosynthesis of anthraquinones in the hairy root culture of Polygonum multiflorum].

Authors:  Rong-Min Yu; Na Ma; Chun-Yan Yan; Yu Zhao
Journal:  Sheng Wu Gong Cheng Xue Bao       Date:  2006-07

5.  Production of anthraquinones, phenolic compounds and biological activities from hairy root cultures of Polygonum multiflorum Thunb.

Authors:  Muthu Thiruvengadam; Nagella Praveen; Eun-Hye Kim; Seung-Hyun Kim; Ill-Min Chung
Journal:  Protoplasma       Date:  2013-10-03       Impact factor: 3.356

Review 6.  Review article: herbal and dietary supplement hepatotoxicity.

Authors:  C Bunchorntavakul; K R Reddy
Journal:  Aliment Pharmacol Ther       Date:  2012-11-05       Impact factor: 8.171

7.  [Toxic hepatitis induced by Polygonum multiflorum].

Authors:  A Banarova; T Koller; J Payer
Journal:  Vnitr Lek       Date:  2012-12

Review 8.  Epidemiology of drug-induced liver injury in China: a systematic analysis of the Chinese literature including 21,789 patients.

Authors:  Yuan Zhou; Li Yang; Zhongli Liao; Xiaoyang He; Yuanyuan Zhou; Hong Guo
Journal:  Eur J Gastroenterol Hepatol       Date:  2013-07       Impact factor: 2.566

9.  Reliability of causality assessment for drug, herbal and dietary supplement hepatotoxicity in the Drug-Induced Liver Injury Network (DILIN).

Authors:  Paul H Hayashi; Huiman X Barnhart; Robert J Fontana; Naga Chalasani; Timothy J Davern; Jayant A Talwalkar; K Rajender Reddy; Andrew A Stolz; Jay H Hoofnagle; Don C Rockey
Journal:  Liver Int       Date:  2014-04-16       Impact factor: 5.828

10.  Perceived efficacy of herbal remedies by users accessing primary healthcare in Trinidad.

Authors:  Yuri N Clement; Jamie Morton-Gittens; Luke Basdeo; Alexander Blades; Marie-Joanna Francis; Natalie Gomes; Meer Janjua; Adelle Singh
Journal:  BMC Complement Altern Med       Date:  2007-02-07       Impact factor: 3.659
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  6 in total

Review 1.  Traditional Chinese Medicine (TCM) and Herbal Hepatotoxicity: RUCAM and the Role of Novel Diagnostic Biomarkers Such as MicroRNAs.

Authors:  Rolf Teschke; Dominique Larrey; Dieter Melchart; Gaby Danan
Journal:  Medicines (Basel)       Date:  2016-07-19

2.  Hepatotoxicity in Rats Induced by Aqueous Extract of Polygoni Multiflori Radix, Root of Polygonum multiflorum Related to the Activity Inhibition of CYP1A2 or CYP2E1.

Authors:  Deng-Ke Li; Jing Chen; Zhen-Zhen Ge; Zhen-Xiao Sun
Journal:  Evid Based Complement Alternat Med       Date:  2017-05-24       Impact factor: 2.629

Review 3.  Polygonum multiflorum-Induced Liver Injury: Clinical Characteristics, Risk Factors, Material Basis, Action Mechanism and Current Challenges.

Authors:  Yi Liu; Wenping Wang; Mingyi Sun; Baorui Ma; Linnuo Pang; Yuanyuan Du; Xiaoxv Dong; Xingbin Yin; Jian Ni
Journal:  Front Pharmacol       Date:  2019-12-13       Impact factor: 5.810

Review 4.  Systematic Review on Chinese Herbal Medicine Induced Liver Injury.

Authors:  Peng Zhang; Yongan Ye; Xianzhao Yang; Yuntao Jiao
Journal:  Evid Based Complement Alternat Med       Date:  2016-08-29       Impact factor: 2.629

Review 5.  Influence Factors on the Hepatotoxicity of Polygoni Multiflori Radix.

Authors:  Yun Wei; Meixia Liu; Jiangang Liu; Hao Li
Journal:  Evid Based Complement Alternat Med       Date:  2019-09-25       Impact factor: 2.629

6.  Metabolomics profiling of Polygoni Multiflori Radix and Polygoni Multiflori Radix Preparata extracts using UPLC-Q/TOF-MS.

Authors:  Zhaoyan Zhang; Liang Yang; Xiaoyan Huang; Yue Gao
Journal:  Chin Med       Date:  2019-10-26       Impact factor: 5.455
  6 in total

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