Literature DB >> 26379972

Association of ADRB1 gene polymorphisms with pain sensitivity in a Chinese population.

Shuang Feng1, Nan Li2, Sheng Xu1, Hao Wang1, Wei Yu1, Yan Lu1, Jianping Cao3, Yan Meng1.   

Abstract

OBJECTIVE: The present study aims to observe the influence of single-nucleotide polymorphisms (SNPs) in the ADRB1 gene on individual differences in pain sensitivity.
METHODS: We analyzed the associations between pain sensitivity and ADRB1 gene SNPs (A145 G and G1165 C) in 324 Chinese patients who underwent surgery. The genotyping was performed using PCR-RFLP technique.
RESULTS: The patients who carried the A-allele of the A145 G SNP were more sensitive to cold pressor-induced pain than those who did not carry this allele (P < 0.05). We did not found G1165 C polymorphism associated with pain sensitive in the present study. The haplotype analysis revealed A-C haplotype carriers have reduced fentanyl use in 24-h postoperative (P < 0.05).
CONCLUSION: ADRB1 gene polymorphisms are associated with pain and analgesic sensitivity.

Entities:  

Keywords:  gene polymorphism; individual difference; opioid; pain; β1-adrenergic receptor

Year:  2015        PMID： 26379972      PMCID： PMC4565355     

Source DB:  PubMed          Journal:  Int J Clin Exp Med        ISSN： 1940-5901


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