Literature DB >> 26378609

Neural immune modulation and immunotherapy assisted by focused ultrasound induced blood-brain barrier opening.

Pin-Yuan Chen1, Kuo-Chen Wei1, Hao-Li Liu2,3.   

Abstract

The central nervous system (CNS) has long been regarded as an immune-privileged site, with the blood-brain barrier (BBB) limiting the entering of systemic immune cells and components. Exposure of low-energy focused ultrasound (FUS) with the presence of microbubbles has been found to provide a temporary and targeted opening of the BBB without inflicting brain damage or inflammation, and is thus an attractive means of delivering CNS therapeutic agents and raising the potential for targeted CNS immunotherapy. Based on our recent studies on enhancing brain-tumor immune-related therapy via this mechanism, (1) we summarize current approaches using FUS-induced BBB opening to promote immune regulation and project potential directions for FUS-induced CNS immunotherapy.

Entities:  

Keywords:  blood-brain barrier; focused ultrasound; immune modulation; immunotherapy

Mesh：

Year:  2015        PMID： 26378609      PMCID： PMC4685696          DOI： 10.1080/21645515.2015.1071749

Source DB:  PubMed          Journal:  Hum Vaccin Immunother        ISSN： 2164-5515            Impact factor:   3.452


  33 in total

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4.  Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption.

Authors:  Manabu Kinoshita; Nathan McDannold; Ferenc A Jolesz; Kullervo Hynynen
Journal:  Proc Natl Acad Sci U S A       Date:  2006-07-25       Impact factor: 11.205

5.  The effect of high-intensity focused ultrasound treatment on immune function in patients with uterine fibroids.

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6.  Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages.

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7.  Prevention of angiogenesis by naked DNA IL-12 gene transfer: angioprevention by immunogene therapy.

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Review 8.  The role of inflammation in Alzheimer's disease.

Authors:  Ehab E Tuppo; Hugo R Arias
Journal:  Int J Biochem Cell Biol       Date:  2005-02       Impact factor: 5.085

9.  Intratumoral LAK cell and interleukin-2 therapy of human gliomas.

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10.  p-Tau immunotherapy reduces soluble and insoluble tau in aged 3xTg-AD mice.

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  8 in total

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Authors:  Charissa Poon; Dallan McMahon; Kullervo Hynynen
Journal:  Neuropharmacology       Date:  2016-02-18       Impact factor: 5.250

Review 3.  Ultrasonic technologies in imaging and drug delivery.

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5.  Sonoselective transfection of cerebral vasculature without blood-brain barrier disruption.

Authors:  Catherine M Gorick; Alexander S Mathew; William J Garrison; E Andrew Thim; Delaney G Fisher; Caitleen A Copeland; Ji Song; Alexander L Klibanov; G Wilson Miller; Richard J Price
Journal:  Proc Natl Acad Sci U S A       Date:  2020-03-02       Impact factor: 11.205

6.  Neuronavigation-guided focused ultrasound for transcranial blood-brain barrier opening and immunostimulation in brain tumors.

Authors:  Ko-Ting Chen; Wen-Yen Chai; Ya-Jui Lin; Chia-Jung Lin; Pin-Yuan Chen; Hong-Chieh Tsai; Chiung-Yin Huang; John S Kuo; Hao-Li Liu; Kuo-Chen Wei
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Review 7.  Ultrasound-mediated microbubble destruction: a new method in cancer immunotherapy.

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8.  Low-frequency HIFU induced cancer immunotherapy: tempting challenges and potential opportunities.

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