| Literature DB >> 26377947 |
Liisa Hantsoo1, C Neill Epperson2.
Abstract
Recently designated as a disorder in the DSM-5, premenstrual dysphoric disorder (PMDD) presents an array of avenues for further research. PMDD's profile, characterized by cognitive-affective symptoms during the premenstruum, is unique from that of other affective disorders in its symptoms and cyclicity. Neurosteroids may be a key contributor to PMDD's clinical presentation and etiology, and represent a potential avenue for drug development. This review will present recent literature on potential contributors to PMDD's pathophysiology, including neurosteroids and stress, and explore potential treatment targets.Entities:
Keywords: GABA; Menstrual cycle; PMDD; PMS; Premenstrual
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Year: 2015 PMID: 26377947 PMCID: PMC4890701 DOI: 10.1007/s11920-015-0628-3
Source DB: PubMed Journal: Curr Psychiatry Rep ISSN: 1523-3812 Impact factor: 5.285