Christiane Lex1,2, Insa Korten3, Alexander Hofmann3, Sabine Renner4, Zsolt Szepfalusi4, Thomas Frischer5, Angela Zacharasiewicz5. 1. Klinik für Pädiatrische Kardiologie und Intensivmedizin, Schwerpunkt Kinderpneumologie/-allergologie, Universitätsmedizin, Robert-Koch-Strasse 40, Göttingen, Deutschland. christiane.lex@med.uni-goettingen.de. 2. Universitätsklinik und Poliklinik für Kinderheilkunde und Jugendmedizin, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Deutschland. christiane.lex@med.uni-goettingen.de. 3. Universitätsklinik und Poliklinik für Kinderheilkunde und Jugendmedizin, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Deutschland. 4. Universitätsklinik für Kinder und Jugendheilkunde, Medizinische Universität Wien, Wien, Österreich. 5. Wilhelminenspital Wien, Wien, Österreich.
Abstract
BACKGROUND: The new lung function reference values of the global lung initiative (GLI) are recommended by most health societies. The aim of this study was to analyze FEV1- and FEV1/FVC-values from a German and Austrian patient group applying old and new reference values. RESULTS: A total of 215 Caucasian children (aged 5-17 years) were included. FEV1-values were significantly lower applying GLI reference values compared to Zapletal values (median 96.9 % pred. (87.3-105.2) versus 100.6 % pred. (quartile 91.5-111.4), p = 0.000), the median difference was 4.9 % (range -12.9 to 27.5) % pred. Differences correlated significantly with age and FEV1 in % predicted (Zapletal), p = 0.000 17/70 (24 %) patients with cystic fibrosis had FEV1-values <80% pred. applying Zapletal, in 25 (36 %) patients FEV1 was abnormal (z-score <1645) using GLI values; 3/145 asthmatics (2 %) had FEV1-Werte <80 % d.S. (Zapletal), 7/145 (5 %) z-scores <1645 (GLI). CONCLUSION: Differences between GLI-and Zapletal-reference values were considerable in pediatric asthma and CF-patients.
BACKGROUND: The new lung function reference values of the global lung initiative (GLI) are recommended by most health societies. The aim of this study was to analyze FEV1- and FEV1/FVC-values from a German and Austrian patient group applying old and new reference values. RESULTS: A total of 215 Caucasian children (aged 5-17 years) were included. FEV1-values were significantly lower applying GLI reference values compared to Zapletal values (median 96.9 % pred. (87.3-105.2) versus 100.6 % pred. (quartile 91.5-111.4), p = 0.000), the median difference was 4.9 % (range -12.9 to 27.5) % pred. Differences correlated significantly with age and FEV1 in % predicted (Zapletal), p = 0.000 17/70 (24 %) patients with cystic fibrosis had FEV1-values <80% pred. applying Zapletal, in 25 (36 %) patients FEV1 was abnormal (z-score <1645) using GLI values; 3/145 asthmatics (2 %) had FEV1-Werte <80 % d.S. (Zapletal), 7/145 (5 %) z-scores <1645 (GLI). CONCLUSION: Differences between GLI-and Zapletal-reference values were considerable in pediatric asthma and CF-patients.
Authors: Philip H Quanjer; Sanja Stanojevic; Tim J Cole; Xaver Baur; Graham L Hall; Bruce H Culver; Paul L Enright; John L Hankinson; Mary S M Ip; Jinping Zheng; Janet Stocks Journal: Eur Respir J Date: 2012-06-27 Impact factor: 16.671