Sanja Stanojevic1, Janet Stocks2, Vassiliki Bountziouka2, Paul Aurora3, Jane Kirkby3, Stephen Bourke4, Siobhán B Carr5, Elaine Gunn6, Ammani Prasad7, Margaret Rosenfeld8, Diana Bilton6. 1. Hospital for Sick Children, Toronto, Canada. Electronic address: Sanja.Stanojevic@sickkids.ca. 2. UCL Institute of Child Health, London, UK. 3. UCL Institute of Child Health, London, UK; Great Ormond Street Hospital for Children NHS Trust, London, UK. 4. Royal Victoria Infirmary, Newcastle upon Tyne, UK. 5. Royal Brompton Hospital, London, UK. 6. Cystic Fibrosis Trust (UK), London, UK. 7. Great Ormond Street Hospital for Children NHS Trust, London, UK. 8. Seattle Children's Hospital, Seattle, WA, USA.
Abstract
BACKGROUND: The Quanjer et al. Global Lung Function Initiative (GLI)-2012 multi-ethnic all-age reference equations for spirometry are endorsed by all major respiratory societies and are the new gold standard. Before the GLI equations are implemented for use in CF patients, the impact of changing equations from those currently used needs to be better understood. METHODS: Annual review data submitted to the UK CF Trust Registry between 2007 and 2011 were used to calculate %predicted FEV1, FVC and FEV1/FVC using three widely used reference equations (Wang-Hankinson and Knudson) and the new GLI-2012 equations. RESULTS: Overall, Knudson and Wang equations overestimated %predicted values in paediatric patients, such that a greater proportion of patients had lung function values in the normal range. Within individual patients, the impact of switching equations varied greatly depending on the patients' age, and which equations were used. CONCLUSIONS: A unified approach to interpreting spirometric lung function measurements would help facilitate more appropriate comparison both within and between centres and countries. Interpretation of longitudinal measurements using a continuous reference equation across all-ages, like the GLI, may further improve our understanding of CF lung disease.
BACKGROUND: The Quanjer et al. Global Lung Function Initiative (GLI)-2012 multi-ethnic all-age reference equations for spirometry are endorsed by all major respiratory societies and are the new gold standard. Before the GLI equations are implemented for use in CF patients, the impact of changing equations from those currently used needs to be better understood. METHODS: Annual review data submitted to the UK CF Trust Registry between 2007 and 2011 were used to calculate %predicted FEV1, FVC and FEV1/FVC using three widely used reference equations (Wang-Hankinson and Knudson) and the new GLI-2012 equations. RESULTS: Overall, Knudson and Wang equations overestimated %predicted values in paediatric patients, such that a greater proportion of patients had lung function values in the normal range. Within individual patients, the impact of switching equations varied greatly depending on the patients' age, and which equations were used. CONCLUSIONS: A unified approach to interpreting spirometric lung function measurements would help facilitate more appropriate comparison both within and between centres and countries. Interpretation of longitudinal measurements using a continuous reference equation across all-ages, like the GLI, may further improve our understanding of CF lung disease.
Authors: Rhonda D Szczesniak; Dan Li; Weiji Su; Cole Brokamp; John Pestian; Michael Seid; John P Clancy Journal: Am J Respir Crit Care Med Date: 2017-08-15 Impact factor: 21.405
Authors: Florian Gahleitner; James Thompson; Claire L Jackson; Jana F Hueppe; Laura Behan; Eleonora Dehlink; Myrofora Goutaki; Florian Halbeisen; Ana Paula L Queiroz; Guillaume Thouvenin; Claudia E Kuehni; Philipp Latzin; Jane S Lucas; Bruna Rubbo Journal: ERJ Open Res Date: 2021-11-29