F Rencz1,2, L Kemény3, J Z Gajdácsi4, W Owczarek5, P Arenberger6, G S Tiplica7, A Stanimirović8, M Niewada9, G Petrova10, L T Marinov10, J Kazandhieva, M Péntek1, V Brodszky1, L Gulácsi1. 1. Department of Health Economics, Corvinus University of Budapest, Budapest, Hungary. 2. Semmelweis University Doctoral School of Clinical Medicine, Budapest, Hungary. 3. Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary. 4. National Health Insurance Fund Administration of Hungary, Budapest, Hungary. 5. Department of Dermatology, Military Institute of Medicine, Warsaw, Poland. 6. Department of Dermatology, Charles University 3rd Medical Faculty, Prague, Czech Republic. 7. Dermatology Clinic 2, Colentina Clinical Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. 8. Department of Clinical Medicine, University of Applied Health Sciences, Zagreb, Croatia. 9. Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland. 10. Department of Social Pharmacy and Pharmacoeconomics, Faculty of Pharmacy, Medical University, Sofia, Bulgaria.
Abstract
OBJECTIVES: To evaluate the use of biological agents for the treatment of psoriasis and to explore country-specific differences within six Central and Eastern European (CEE) countries, namely Bulgaria, Croatia, the Czech Republic, Hungary, Poland and Romania. METHODS: A literature overview on the epidemiology and disease burden of psoriasis in CEE was conducted. The number of patients treated with biologics was obtained from patient registries, ministries of health, national professional societies and health insurance funds. Biological treatment rates were estimated by two different methods: (i) as a proportion of all psoriasis patients of a country (assuming a common prevalence of psoriasis 2%) and (ii) per 100,000 population. Moreover, we provide a detailed comparison of drug coverage policies and guidelines regulating the treatment with biologics in psoriasis. RESULTS: On average 0.25% of all psoriasis patients, or five psoriasis patients out of 100,000 inhabitants are treated with biologics embedding a 14.6-fold difference between the six countries. Bulgaria, Croatia and Poland lag behind the other three countries in the use of biologics. The significant differences among CEE countries cannot be explained by variations in prices of biologics, cost-effectiveness or budget impact of biologics. It seems that the time since coverage decision, the fewer number of covered biologics, the more restrictive criteria to be eligible for covered treatment in terms of baseline Psoriasis Area and Severity Index and Dermatology Life Quality Index scores, and the maximum duration of treatment allowed are responsible for the majority of the differences. CONCLUSIONS: There exists a disconnect between the European psoriasis treatment guidelines and the various CEE country-specific biologic coverage eligibilities. The cost of biologic therapy for psoriasis is not solely and directly responsible for the different use rates amongst the CEE countries. Psoriasis may not be perceived by all payers as a serious disease that can be successfully treated in a cost-effective manner.
OBJECTIVES: To evaluate the use of biological agents for the treatment of psoriasis and to explore country-specific differences within six Central and Eastern European (CEE) countries, namely Bulgaria, Croatia, the Czech Republic, Hungary, Poland and Romania. METHODS: A literature overview on the epidemiology and disease burden of psoriasis in CEE was conducted. The number of patients treated with biologics was obtained from patient registries, ministries of health, national professional societies and health insurance funds. Biological treatment rates were estimated by two different methods: (i) as a proportion of all psoriasispatients of a country (assuming a common prevalence of psoriasis 2%) and (ii) per 100,000 population. Moreover, we provide a detailed comparison of drug coverage policies and guidelines regulating the treatment with biologics in psoriasis. RESULTS: On average 0.25% of all psoriasispatients, or five psoriasispatients out of 100,000 inhabitants are treated with biologics embedding a 14.6-fold difference between the six countries. Bulgaria, Croatia and Poland lag behind the other three countries in the use of biologics. The significant differences among CEE countries cannot be explained by variations in prices of biologics, cost-effectiveness or budget impact of biologics. It seems that the time since coverage decision, the fewer number of covered biologics, the more restrictive criteria to be eligible for covered treatment in terms of baseline Psoriasis Area and Severity Index and Dermatology Life Quality Index scores, and the maximum duration of treatment allowed are responsible for the majority of the differences. CONCLUSIONS: There exists a disconnect between the European psoriasis treatment guidelines and the various CEE country-specific biologic coverage eligibilities. The cost of biologic therapy for psoriasis is not solely and directly responsible for the different use rates amongst the CEE countries. Psoriasis may not be perceived by all payers as a serious disease that can be successfully treated in a cost-effective manner.
Authors: Fanni Rencz; Petra Baji; László Gulácsi; Sarolta Kárpáti; Márta Péntek; Adrienn Katalin Poór; Valentin Brodszky Journal: Qual Life Res Date: 2015-12-18 Impact factor: 4.147
Authors: Adrienn Katalin Poór; Fanni Rencz; Valentin Brodszky; László Gulácsi; Zsuzsanna Beretzky; Bernadett Hidvégi; Péter Holló; Sarolta Kárpáti; Márta Péntek Journal: Qual Life Res Date: 2017-09-05 Impact factor: 4.147
Authors: Fanni Rencz; Ariel Z Mitev; Ákos Szabó; Zsuzsanna Beretzky; Adrienn K Poór; Péter Holló; Norbert Wikonkál; Miklós Sárdy; Sarolta Kárpáti; Andrea Szegedi; Éva Remenyik; Valentin Brodszky Journal: Qual Life Res Date: 2021-03-08 Impact factor: 4.147
Authors: Cécile Rémuzat; Anna Kapuśniak; Aleksandra Caban; Dan Ionescu; Guerric Radière; Cyril Mendoza; Mondher Toumi Journal: J Mark Access Health Policy Date: 2017-04-28
Authors: Valentin Brodszky; Anikó Bíró; Zoltán Szekanecz; Boglárka Soós; Petra Baji; Fanni Rencz; László Tóthfalusi; László Gulácsi; Márta Péntek Journal: Clinicoecon Outcomes Res Date: 2017-02-15