Literature DB >> 26369972

Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68.

Liang Sun1, Adam Meijer2, Mathy Froeyen3, Linlin Zhang4, Hendrik Jan Thibaut5, Jim Baggen6, Shyla George7, John Vernachio8, Frank J M van Kuppeveld6, Pieter Leyssen1, Rolf Hilgenfeld4, Johan Neyts9, Leen Delang1.   

Abstract

We investigated the susceptibility of 10 enterovirus D68 (EV-D68) isolates (belonging to clusters A, B, and C) to (entero)virus inhibitors with different mechanisms of action. The 3C-protease inhibitors proved to be more efficient than enviroxime and pleconaril, which in turn were more effective than vapendavir and pirodavir. Favipiravir proved to be a weak inhibitor. Resistance to pleconaril maps to V69A in the VP1 protein, and resistance to rupintrivir maps to V104I in the 3C protease. A structural explanation of why both substitutions may cause resistance is provided.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26369972      PMCID： PMC4649165          DOI： 10.1128/AAC.01375-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

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Authors:  J M Groarke; D C Pevear
Journal:  J Infect Dis       Date:  1999-06       Impact factor: 5.226

2.  UCSF Chimera--a visualization system for exploratory research and analysis.

Authors:  Eric F Pettersen; Thomas D Goddard; Conrad C Huang; Gregory S Couch; Daniel M Greenblatt; Elaine C Meng; Thomas E Ferrin
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3.  A novel outbreak enterovirus D68 strain associated with acute flaccid myelitis cases in the USA (2012-14): a retrospective cohort study.

Authors:  Alexander L Greninger; Samia N Naccache; Kevin Messacar; Anna Clayton; Guixia Yu; Sneha Somasekar; Scot Federman; Doug Stryke; Christopher Anderson; Shigeo Yagi; Sharon Messenger; Debra Wadford; Dongxiang Xia; James P Watt; Keith Van Haren; Samuel R Dominguez; Carol Glaser; Grace Aldrovandi; Charles Y Chiu
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4.  Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral.

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Journal:  J Antimicrob Chemother       Date:  2014-06-20       Impact factor: 5.790

5.  Two cases of acute severe flaccid myelitis associated with enterovirus D68 infection in children, Norway, autumn 2014.

Authors:  H C Pfeiffer; K Bragstad; M K Skram; H Dahl; P K Knudsen; M S Chawla; M Holberg-Petersen; K Vainio; S G Dudman; A M Kran; A E Rojahn
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6.  Peptidyl aldehyde NK-1.8k suppresses enterovirus 71 and enterovirus 68 infection by targeting protease 3C.

Authors:  Yaxin Wang; Ben Yang; Yangyang Zhai; Zheng Yin; Yuna Sun; Zihe Rao
Journal:  Antimicrob Agents Chemother       Date:  2015-02-17       Impact factor: 5.191

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Journal:  Ann Am Thorac Soc       Date:  2015-05

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Review 9.  Favipiravir (T-705), a novel viral RNA polymerase inhibitor.

Authors:  Yousuke Furuta; Brian B Gowen; Kazumi Takahashi; Kimiyasu Shiraki; Donald F Smee; Dale L Barnard
Journal:  Antiviral Res       Date:  2013-09-29       Impact factor: 5.970

10.  Seven Strains of Enterovirus D68 Detected in the United States during the 2014 Severe Respiratory Disease Outbreak.

Authors:  B A Brown; W A Nix; M Sheth; M Frace; M S Oberste
Journal:  Genome Announc       Date:  2014-11-20
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  23 in total

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Journal:  Bio Protoc       Date:  2017-03-20

5.  Susceptibilities of enterovirus D68, enterovirus 71, and rhinovirus 87 strains to various antiviral compounds.

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Journal:  Antiviral Res       Date:  2016-04-07       Impact factor: 5.970

6.  Pharmacological Characterization of the Mechanism of Action of R523062, a Promising Antiviral for Enterovirus D68.

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Journal:  ACS Infect Dis       Date:  2020-08-05       Impact factor: 5.084

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8.  Evaluating Treatment Efficacy in a Mouse Model of Enterovirus D68-Associated Paralytic Myelitis.

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Journal:  J Infect Dis       Date:  2017-12-05       Impact factor: 5.226

9.  Cryo-EM structure of pleconaril-resistant rhinovirus-B5 complexed to the antiviral OBR-5-340 reveals unexpected binding site.

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