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Literature DB >> 26366338

Regulation of miRNAs by agents targeting the tumor stem cell markers DCLK1, MSI1, LGR5, and BMI1.

Sripathi M Sureban¹, Dongfeng Qu¹, Courtney W Houchen¹.

Abstract

Gastrointestinal cancers such as colorectal, pancreatic, liver, gastric, and esophageal, are the most common forms of malignant cancers. MicroRNAs (miRNA) play important role in regulating gastrointestinal cancer progress either as potent oncogenes or tumor suppressors. In this report, we will discuss the importance of several tumor suppressors involved in colon or pancreatic cancer. Some recent studies on tumor stem cells and regulation of these miRNAs via agents targeting the tumor stem cell markers doublecortin-like kinase 1 (DCLK1), Musashi-1 (MSI1), polycomb protein BMI1, and WNT genes (LGR5 and ASCL2) will also be discussed. Agents such as siRNA/shRNA, small molecule kinase inhibitors, and general herbal drugs (curcumin) targeting these tumor stem cell markers and tumor suppressor miRNAs could be the perfect therapeutic agents for the treatment of these cancers.

Entities: Chemical Disease Gene Species

Keywords: BMI1; DCLK1; LGR5; MSI1; Tumor stem cell markers; Tumor suppressor miRNAs

Year: 2015 PMID： 26366338 PMCID： PMC4562791 DOI： 10.1007/s40495-014-0006-6

Source DB: PubMed Journal: Curr Pharmacol Rep ISSN： 2198-641X

55 in total

1. DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism.

Authors: Sripathi M Sureban; Randal May; Stan A Lightfoot; Aimee B Hoskins; Megan Lerner; Daniel J Brackett; Russell G Postier; Rama Ramanujam; Altaf Mohammed; Chinthalapally V Rao; James H Wyche; Shrikant Anant; Courtney W Houchen
Journal: Cancer Res Date: 2011-02-01 Impact factor: 12.701

2. Bmi1 is expressed in vivo in intestinal stem cells.

Authors: Eugenio Sangiorgi; Mario R Capecchi
Journal: Nat Genet Date: 2008-06-08 Impact factor: 38.330

3. Identification of a novel putative pancreatic stem/progenitor cell marker DCAMKL-1 in normal mouse pancreas.

Authors: Randal May; Sripathi M Sureban; Stan A Lightfoot; Aimee B Hoskins; Daniel J Brackett; Russell G Postier; Rama Ramanujam; Chinthalapally V Rao; James H Wyche; Shrikant Anant; Courtney W Houchen
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2010-06-03 Impact factor: 4.052

4. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors.

Authors: P Mathijs Voorhoeve; Carlos le Sage; Mariette Schrier; Ad J M Gillis; Hans Stoop; Remco Nagel; Ying-Poi Liu; Josyanne van Duijse; Jarno Drost; Alexander Griekspoor; Eitan Zlotorynski; Norikazu Yabuta; Gabriella De Vita; Hiroshi Nojima; Leendert H J Looijenga; Reuven Agami
Journal: Cell Date: 2006-03-24 Impact factor: 41.582

5. RAS is regulated by the let-7 microRNA family.

Authors: Steven M Johnson; Helge Grosshans; Jaclyn Shingara; Mike Byrom; Rich Jarvis; Angie Cheng; Emmanuel Labourier; Kristy L Reinert; David Brown; Frank J Slack
Journal: Cell Date: 2005-03-11 Impact factor: 41.582

6. Mechanisms of disease: epithelial-mesenchymal transition--does cellular plasticity fuel neoplastic progression?

Authors: Eva A Turley; Mandana Veiseh; Derek C Radisky; Mina J Bissell
Journal: Nat Clin Pract Oncol Date: 2008-03-18

7. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis.

Authors: Nozomu Yanaihara; Natasha Caplen; Elise Bowman; Masahiro Seike; Kensuke Kumamoto; Ming Yi; Robert M Stephens; Aikou Okamoto; Jun Yokota; Tadao Tanaka; George Adrian Calin; Chang-Gong Liu; Carlo M Croce; Curtis C Harris
Journal: Cancer Cell Date: 2006-03 Impact factor: 31.743

8. Identification of pancreatic cancer stem cells.

Authors: Chenwei Li; David G Heidt; Piero Dalerba; Charles F Burant; Lanjing Zhang; Volkan Adsay; Max Wicha; Michael F Clarke; Diane M Simeone
Journal: Cancer Res Date: 2007-02-01 Impact factor: 12.701

9. CD24 can be used to isolate Lgr5+ putative colonic epithelial stem cells in mice.

Authors: Jeffrey B King; Richard J von Furstenberg; Brian J Smith; Kirk K McNaughton; Joseph A Galanko; Susan J Henning
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2012-06-21 Impact factor: 4.052

10. Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells.

Authors: Rong Zhu; Yongtao Yang; Yin Tian; Jianying Bai; Xin Zhang; Xiaohuan Li; Zhihong Peng; Yonghong He; Lei Chen; Qiong Pan; Dianchun Fang; Wensheng Chen; Chen Qian; Xiuwu Bian; Rongquan Wang
Journal: PLoS One Date: 2012-02-23 Impact factor: 3.240

6 in total

Regulation of miRNAs by agents targeting the tumor stem cell markers DCLK1, MSI1, LGR5, and BMI1.

1. DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism.

2. Bmi1 is expressed in vivo in intestinal stem cells.

3. Identification of a novel putative pancreatic stem/progenitor cell marker DCAMKL-1 in normal mouse pancreas.

4. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors.

5. RAS is regulated by the let-7 microRNA family.

6. Mechanisms of disease: epithelial-mesenchymal transition--does cellular plasticity fuel neoplastic progression?

7. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis.

8. Identification of pancreatic cancer stem cells.

9. CD24 can be used to isolate Lgr5+ putative colonic epithelial stem cells in mice.

10. Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells.

Review 1. Curcumin AntiCancer Studies in Pancreatic Cancer.

2. A novel double-targeted nondrug delivery system for targeting cancer stem cells.

3. Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients.

Review 4. Oncolytic viruses against cancer stem cells: A promising approach for gastrointestinal cancer.

5. Expression Patterns for TETs, LGR5 and BMI1 in Cancer Stem-like Cells Isolated from Human Colon Cancer.

Review 6. microRNA: The Impact on Cancer Stemness and Therapeutic Resistance.