Literature DB >> 18349857

Mechanisms of disease: epithelial-mesenchymal transition--does cellular plasticity fuel neoplastic progression?

Eva A Turley1, Mandana Veiseh, Derek C Radisky, Mina J Bissell.   

Abstract

Epithelial-mesenchymal transition (EMT) is a phenotypic conversion that facilitates organ morphogenesis and tissue remodeling in physiological processes, such as embryonic development and wound healing. A similar phenotypic conversion is also detected in fibrotic diseases and neoplasia, and is associated with disease progression. EMT in cancer epithelial cells often seems to be an incomplete and bidirectional process. In this Review, we discuss the phenomenon of EMT as it pertains to tumor development, focusing on exceptions to the commonly held rule that EMT promotes invasion and metastasis. We also highlight the role of RAS-controlled signaling mediators, ERK1, ERK2 and phosphatidylinositol 3-kinase, as microenvironmental responsive regulators of EMT.

Entities:  

Mesh：

Year:  2008        PMID： 18349857      PMCID： PMC2846172          DOI： 10.1038/ncponc1089

Source DB:  PubMed          Journal:  Nat Clin Pract Oncol        ISSN： 1743-4254


  92 in total

Review 1.  Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT?

Authors:  Derek C Radisky; Paraic A Kenny; Mina J Bissell
Journal:  J Cell Biochem       Date:  2007-07-01       Impact factor: 4.429

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Authors:  F Strutz; M Zeisberg; A Renziehausen; B Raschke; V Becker; C van Kooten; G Müller
Journal:  Kidney Int       Date:  2001-02       Impact factor: 10.612

3.  Phosphorylation of ERK1/2 mitogen-activated protein kinase is associated with poor response to anti-hormonal therapy and decreased patient survival in clinical breast cancer.

Authors:  J M Gee; J F Robertson; I O Ellis; R I Nicholson
Journal:  Int J Cancer       Date:  2001-07-20       Impact factor: 7.396

Review 4.  ERK implication in cell cycle regulation.

Authors:  Jean-Claude Chambard; Renaud Lefloch; Jacques Pouysségur; Philippe Lenormand
Journal:  Biochim Biophys Acta       Date:  2006-11-17

5.  Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta.

Authors:  J Zavadil; M Bitzer; D Liang; Y C Yang; A Massimi; S Kneitz; E Piek; E P Bottinger
Journal:  Proc Natl Acad Sci U S A       Date:  2001-06-05       Impact factor: 11.205

6.  A high-throughput study in melanoma identifies epithelial-mesenchymal transition as a major determinant of metastasis.

Authors:  Soledad R Alonso; Lorraine Tracey; Pablo Ortiz; Beatriz Pérez-Gómez; José Palacios; Marina Pollán; Juan Linares; Salvio Serrano; Ana I Sáez-Castillo; Lydia Sánchez; Raquel Pajares; Abel Sánchez-Aguilera; Maria J Artiga; Miguel A Piris; José L Rodríguez-Peralto
Journal:  Cancer Res       Date:  2007-04-01       Impact factor: 12.701

7.  Biological and clinical associations of c-jun activation in human breast cancer.

Authors:  J M Gee; A F Barroso; I O Ellis; J F Robertson; R I Nicholson
Journal:  Int J Cancer       Date:  2000-03-20       Impact factor: 7.396

8.  Ultraviolet radiation stimulates expression of Snail family transcription factors in keratinocytes.

Authors:  Laurie G Hudson; Changsun Choi; Kimberly M Newkirk; Jaipriya Parkhani; Karen L Cooper; Ping Lu; Donna F Kusewitt
Journal:  Mol Carcinog       Date:  2007-04       Impact factor: 4.784

9.  Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial-mesenchymal transition.

Authors:  H C Lien; Y H Hsiao; Y S Lin; Y T Yao; H F Juan; W H Kuo; Mien-Chie Hung; K J Chang; F J Hsieh
Journal:  Oncogene       Date:  2007-07-02       Impact factor: 9.867

10.  A mouse stromal response to tumor invasion predicts prostate and breast cancer patient survival.

Authors:  Marina Bacac; Paolo Provero; Nathalie Mayran; Jean-Christophe Stehle; Carlo Fusco; Ivan Stamenkovic
Journal:  PLoS One       Date:  2006-12-20       Impact factor: 3.240
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  123 in total

1.  Growth factor- and cytokine-driven pathways governing liver stemness and differentiation.

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Journal:  World J Gastroenterol       Date:  2010-11-07       Impact factor: 5.742

2.  Functional role of gangliotetraosylceramide in epithelial-to-mesenchymal transition process induced by hypoxia and by TGF-{beta}.

Authors:  Feng Guan; Lana Schaffer; Kazuko Handa; Sen-Itiroh Hakomori
Journal:  FASEB J       Date:  2010-08-18       Impact factor: 5.191

3.  Involvement of O-glycosylation defining oncofetal fibronectin in epithelial-mesenchymal transition process.

Authors:  Leonardo Freire-de-Lima; Kirill Gelfenbeyn; Yao Ding; Ulla Mandel; Henrik Clausen; Kazuko Handa; Sen-Itiroh Hakomori
Journal:  Proc Natl Acad Sci U S A       Date:  2011-10-17       Impact factor: 11.205

4.  The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases.

Authors:  William P Ranahan; Zhang Han; Whitney Smith-Kinnaman; Sarah C Nabinger; Brigitte Heller; Britney-Shea Herbert; Rebecca Chan; Clark D Wells
Journal:  Cancer Res       Date:  2011-02-01       Impact factor: 12.701

5.  DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism.

Authors:  Sripathi M Sureban; Randal May; Stan A Lightfoot; Aimee B Hoskins; Megan Lerner; Daniel J Brackett; Russell G Postier; Rama Ramanujam; Altaf Mohammed; Chinthalapally V Rao; James H Wyche; Shrikant Anant; Courtney W Houchen
Journal:  Cancer Res       Date:  2011-02-01       Impact factor: 12.701

6.  Ras Signaling in Breast Cancer.

Authors:  Aree Moon
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

7.  Sensitizing ovarian cancer cells to chemotherapy by interfering with pathways that are involved in the formation of cancer stem cells.

Authors:  Kamola Saydaminova; Robert Strauss; Min Xie; Jiri Bartek; Maximilian Richter; Ruan van Rensburg; Charles Drescher; Anja Ehrhardt; Sheng Ding; André Lieber
Journal:  Cancer Biol Ther       Date:  2016-08-30       Impact factor: 4.742

8.  Hyaluronan-CD44 Interactions in Cancer: Paradoxes and Possibilities.

Authors:  Bryan P Toole
Journal:  Clin Cancer Res       Date:  2009-12-15       Impact factor: 12.531

9.  Identification of pY654-β-catenin as a critical co-factor in hypoxia-inducible factor-1α signaling and tumor responses to hypoxia.

Authors:  Y Xi; Y Wei; B Sennino; A Ulsamer; I Kwan; A N Brumwell; K Tan; M K Aghi; D M McDonald; D M Jablons; H A Chapman
Journal:  Oncogene       Date:  2012-12-17       Impact factor: 9.867

10.  Inhibition of TBK1 attenuates radiation-induced epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1.

Authors:  Wen Liu; Yi-Juan Huang; Cong Liu; Yan-Yong Yang; Hu Liu; Jian-Guo Cui; Ying Cheng; Fu Gao; Jian-Ming Cai; Bai-Long Li
Journal:  Lab Invest       Date:  2014-01-27       Impact factor: 5.662
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