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Literature DB >> 263654

Age, thymic involution, and circulating thymic hormone activity.

V M Lewis, J J Twomey, P Bealmear, G Goldstein, R A Good.

Abstract

Circulating thymic hormone activity and thymic histology were studied in patients undergoing open heart surgery. Plasma thymic hormone activity was measured using a bioassay based upon thymocyte antigen induction on null mouse lymphocytes. Activity was highest at 15-30 yr of age and declined thereafter, being negligible after the sixth age decade. The age-related decline of circulating thymic hormone activity correlated, in general, with progressive thymic involution. However, hormone activity was detected in plasma from some cases with advanced involution, suggesting that the normal young thymus may have considerable functional reserve.

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Year: 1978 PMID： 263654 DOI： 10.1210/jcem-47-1-145

Source DB: PubMed Journal: J Clin Endocrinol Metab ISSN： 0021-972X Impact factor: 5.958

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Cited

14 in total

1. The influence of immune function on lifespan.

Authors: M E Weksler
Journal: Bull N Y Acad Med Date: 1978-11

2. Null cell senescence and its potential significance to the immunobiology of aging.

Authors: J J Twomey; R J Luchi; N M Kouttab
Journal: J Clin Invest Date: 1982-07 Impact factor: 14.808

3. Production of auto-anti-idiotypic antibody during the normal immune response: changes in the auto-anti-idiotypic antibody response and the idiotype repertoire associated with aging.

Authors: E A Goidl; G J Thorbecke; M E Weksler; G W Siskind
Journal: Proc Natl Acad Sci U S A Date: 1980-11 Impact factor: 11.205

10. Immunoregulation in senescence: increased inducibility of antigen-specific suppressor T cells and loss of cell sensitivity to immunosuppression in aging mice.

Authors: G Doria; C Mancini; L Adorini
Journal: Proc Natl Acad Sci U S A Date: 1982-06 Impact factor: 11.205

Age, thymic involution, and circulating thymic hormone activity.

1. The influence of immune function on lifespan.

2. Null cell senescence and its potential significance to the immunobiology of aging.

3. Production of auto-anti-idiotypic antibody during the normal immune response: changes in the auto-anti-idiotypic antibody response and the idiotype repertoire associated with aging.

4. Effect of the TP5 analogue of thymopoietin on the rejection of male skin by aged and thymectomized female mice.

5. Age-related changes in human thymus.

6. Neuroendocrine-thymus interactions. I. In vitro modulation of thymic factor secretion by thyroid hormones.

Review 7. Thymopoietin to thymopentin: experimental studies.

8. Involution of the rat thymus in experimentally induced hypothyroidism.

Review 9. Thymopentin and splenopentin as immunomodulators. Current status.

10. Immunoregulation in senescence: increased inducibility of antigen-specific suppressor T cells and loss of cell sensitivity to immunosuppression in aging mice.