Literature DB >> 26363889

Actifit® scaffold implantation: Influence of preoperative meniscal extrusion on morphological and clinical outcomes.

B Faivre1, H Bouyarmane2, G Lonjon3, P Boisrenoult4, N Pujol4, P Beaufils4.   

Abstract

BACKGROUND: Meniscal substitutes have been suggested for the treatment of knee pain after partial meniscectomy. However, despite the partial nature of the initial meniscectomy, secondary extrusion of the substitute is common. The primary objective of this study was to evaluate morphological outcomes of meniscal substitute implantation and their potential associations with preoperative meniscal extrusion. HYPOTHESIS: Preoperative absolute meniscal extrusion in the coronal plane predicts poorer morphological and clinical outcomes.
MATERIAL AND METHODS: Consecutive patients who received an Actifit(®) meniscal substitute between 2008 and 2011 were included prospectively. After 1 year and 2 years, the IKDC score and KOOS were determined and magnetic resonance imaging performed. The morphological evaluation consisted in measuring meniscal extrusion and cartilage coverage by the substitute in the coronal and sagittal planes.
RESULTS: Twenty patients were included. Among them, 3 required subsequent removal of the substitute. The mean subjective IKDC score increased from 48.1 preoperatively to 56.4 after 2 years. Over the same period, the function/sports/recreational activities component of the KOOS improved significantly (42.9 vs. 55.0, P=0.04). Positive correlations between preoperative and 1-year values were demonstrated for both cartilage coverage in the coronal and the sagittal planes (P=0.03 and P=0.04, respectively) and coronal absolute meniscal extrusion (P=0.05). No significant differences were found between preoperative and 2-year values of cartilage coverage in the coronal and sagittal planes (P=0.38). There was a negative correlation linking preoperative meniscal extrusion in the coronal plane to 1-year cartilage coverage in the coronal and sagittal planes (P=0.01 and P=0.04, respectively). Preoperative absolute meniscal extrusion in the coronal plane correlated negatively with the subjective IKDC score after 1 year (P=0.02). DISCUSSION: Preoperative meniscal extrusion in the coronal plane strongly predicts clinical and morphological outcomes. Marked preoperative meniscal extrusion, even in a patient with symptoms after partial meniscectomy, should prompt an appraisal of whether allograft replacement may be more appropriate than a meniscal substitute. LEVEL OF EVIDENCE: IV, prospective study.
Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Actifit(®); Meniscus extrusion; Meniscus scaffold; Partial meniscectomy

Mesh:

Year:  2015        PMID: 26363889     DOI: 10.1016/j.otsr.2015.06.016

Source DB:  PubMed          Journal:  Orthop Traumatol Surg Res        ISSN: 1877-0568            Impact factor:   2.256


  7 in total

1.  Polyurethane-based cell-free scaffold for the treatment of painful partial meniscus loss.

Authors:  G Filardo; E Kon; F Perdisa; A Sessa; A Di Martino; M Busacca; S Zaffagnini; M Marcacci
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2016-07-09       Impact factor: 4.342

2.  Polyurethane meniscal scaffolds lead to better clinical outcomes but worse articular cartilage status and greater absolute meniscal extrusion.

Authors:  Young-Soo Shin; Hoon-Nyun Lee; Hyun-Bo Sim; Hyun-Jung Kim; Dae-Hee Lee
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2017-07-26       Impact factor: 4.342

Review 3.  Similar clinical outcomes following collagen or polyurethane meniscal scaffold implantation: a systematic review.

Authors:  Darby A Houck; Matthew J Kraeutler; John W Belk; Eric C McCarty; Jonathan T Bravman
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2018-01-16       Impact factor: 4.342

4.  [Research progress of scaffold materials for tissue engineered meniscus].

Authors:  Ziyan Feng; Yifei Fan; Jiusi Guo; Weili Fu
Journal:  Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi       Date:  2019-08-15

5.  Clinical application of polyurethane meniscal scaffold: A meta-analysis.

Authors:  Wei Li; Jianying Pan; Jintao Li; Jinshan Guo; Chun Zeng; Denghui Xie
Journal:  J Orthop       Date:  2021-02-20

Review 6.  Meniscal substitution, a developing and long-awaited demand.

Authors:  Philipp W Winkler; Benjamin B Rothrauff; Rafael A Buerba; Neha Shah; Stefano Zaffagnini; Peter Alexander; Volker Musahl
Journal:  J Exp Orthop       Date:  2020-07-25

7.  First Clinical Application of Polyurethane Meniscal Scaffolds with Mesenchymal Stem Cells and Assessment of Cartilage Quality with T2 Mapping at 12 Months.

Authors:  Anell Olivos-Meza; Francisco Javier Pérez Jiménez; Julio Granados-Montiel; Carlos Landa-Solís; Socorro Cortés González; Cesar Alejandro Jiménez Aroche; Marco Valdez Chávez; Saúl Renán León; Ricardo Gomez-Garcia; Valentin Martínez-López; Carmina Ortega-Sánchez; Carmen Parra-Cid; Cristina Velasquillo Martinez; Clemente Ibarra
Journal:  Cartilage       Date:  2019-08-07       Impact factor: 3.117

  7 in total

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