Literature DB >> 26355212

Blowing Off Steam: Virus Inhibition of cGAS DNA Sensing.

Benjamin A Diner1, Ileana M Cristea2.   

Abstract

Detection of viral DNA is essential for eliciting mammalian innate immunity. However, viruses have acquired effective mechanisms for blocking host defense. Indeed, in this issue of Cell Host & Microbe, Wu et al. (2015) discover a herpesviral strategy for inhibiting the prominent host sensor of viral DNA, cGAS.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 26355212      PMCID： PMC4920077          DOI： 10.1016/j.chom.2015.08.012

Source DB:  PubMed          Journal:  Cell Host Microbe        ISSN： 1931-3128            Impact factor:   21.023


  10 in total

1.  Transmission of innate immune signaling by packaging of cGAMP in viral particles.

Authors:  Matteo Gentili; Joanna Kowal; Mercedes Tkach; Takeshi Satoh; Xavier Lahaye; Cécile Conrad; Marilyn Boyron; Bérangère Lombard; Sylvère Durand; Guido Kroemer; Damarys Loew; Marc Dalod; Clotilde Théry; Nicolas Manel
Journal:  Science       Date:  2015-07-30       Impact factor: 47.728

2.  cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection.

Authors:  Megan H Orzalli; Nicole M Broekema; Benjamin A Diner; Dustin C Hancks; Nels C Elde; Ileana M Cristea; David M Knipe
Journal:  Proc Natl Acad Sci U S A       Date:  2015-03-23       Impact factor: 11.205

3.  Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein.

Authors:  Megan H Orzalli; Neal A DeLuca; David M Knipe
Journal:  Proc Natl Acad Sci U S A       Date:  2012-10-01       Impact factor: 11.205

4.  Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.

Authors:  Jiaxi Wu; Lijun Sun; Xiang Chen; Fenghe Du; Heping Shi; Chuo Chen; Zhijian J Chen
Journal:  Science       Date:  2012-12-20       Impact factor: 47.728

5.  Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.

Authors:  Lijun Sun; Jiaxi Wu; Fenghe Du; Xiang Chen; Zhijian J Chen
Journal:  Science       Date:  2012-12-20       Impact factor: 47.728

6.  Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein.

Authors:  Jian-jun Wu; Wenwei Li; Yaming Shao; Denis Avey; Bishi Fu; Joseph Gillen; Travis Hand; Siming Ma; Xia Liu; Wendell Miley; Andreas Konrad; Frank Neipel; Michael Stürzl; Denise Whitby; Hong Li; Fanxiu Zhu
Journal:  Cell Host Microbe       Date:  2015-08-27       Impact factor: 21.023

7.  Human cytomegalovirus tegument protein pUL83 inhibits IFI16-mediated DNA sensing for immune evasion.

Authors:  Tuo Li; Jin Chen; Ileana M Cristea
Journal:  Cell Host Microbe       Date:  2013-11-13       Impact factor: 21.023

8.  A diverse range of gene products are effectors of the type I interferon antiviral response.

Authors:  John W Schoggins; Sam J Wilson; Maryline Panis; Mary Y Murphy; Christopher T Jones; Paul Bieniasz; Charles M Rice
Journal:  Nature       Date:  2011-04-10       Impact factor: 49.962

9.  Viruses transfer the antiviral second messenger cGAMP between cells.

Authors:  A Bridgeman; J Maelfait; T Davenne; T Partridge; Y Peng; A Mayer; T Dong; V Kaever; P Borrow; J Rehwinkel
Journal:  Science       Date:  2015-07-30       Impact factor: 47.728

10.  cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

Authors:  Andrea Ablasser; Marion Goldeck; Taner Cavlar; Tobias Deimling; Gregor Witte; Ingo Röhl; Karl-Peter Hopfner; Janos Ludwig; Veit Hornung
Journal:  Nature       Date:  2013-05-30       Impact factor: 49.962
  10 in total
  6 in total

1.  Human Cytomegalovirus Tegument Protein pp65 (pUL83) Dampens Type I Interferon Production by Inactivating the DNA Sensor cGAS without Affecting STING.

Authors:  Matteo Biolatti; Valentina Dell'Oste; Sara Pautasso; Francesca Gugliesi; Jens von Einem; Christian Krapp; Martin Roelsgaard Jakobsen; Cinzia Borgogna; Marisa Gariglio; Marco De Andrea; Santo Landolfo
Journal:  J Virol       Date:  2018-02-26       Impact factor: 5.103

2.  High Efficiency CRISPR/Cas9-mediated Gene Editing in Primary Human T-cells Using Mutant Adenoviral E4orf6/E1b55k "Helper" Proteins.

Authors:  Kamila S Gwiazda; Alexandra E Grier; Jaya Sahni; Stephen M Burleigh; Unja Martin; Julia G Yang; Nicholas A Popp; Michelle C Krutein; Iram F Khan; Kyle Jacoby; Michael C Jensen; David J Rawlings; Andrew M Scharenberg
Journal:  Mol Ther       Date:  2016-05-16       Impact factor: 11.454

3.  Kaposi's Sarcoma-Associated Herpesvirus Inhibitor of cGAS (KicGAS), Encoded by ORF52, Is an Abundant Tegument Protein and Is Required for Production of Infectious Progeny Viruses.

Authors:  Wenwei Li; Denis Avey; Bishi Fu; Jian-Jun Wu; Siming Ma; Xia Liu; Fanxiu Zhu
Journal:  J Virol       Date:  2016-05-12       Impact factor: 5.103

4.  Histone H2B-IFI16 Recognition of Nuclear Herpesviral Genome Induces Cytoplasmic Interferon-β Responses.

Authors:  Jawed Iqbal; Mairaj Ahmed Ansari; Binod Kumar; Dipanjan Dutta; Arunava Roy; Leela Chikoti; Gina Pisano; Sujoy Dutta; Shahrooz Vahedi; Mohanan Valiya Veettil; Bala Chandran
Journal:  PLoS Pathog       Date:  2016-10-20       Impact factor: 6.823

Review 5.  Subversion of Host Innate Immunity by Human Papillomavirus Oncoproteins.

Authors:  Irene Lo Cigno; Federica Calati; Silvia Albertini; Marisa Gariglio
Journal:  Pathogens       Date:  2020-04-17

6.  DNA Sensors' Signaling in NK Cells During HHV-6A, HHV-6B and HHV-7 Infection.

Authors:  Daria Bortolotti; Valentina Gentili; Elisabetta Caselli; Mariangela Sicolo; Irene Soffritti; Maria D'Accolti; Isabel Barao; Antonella Rotola; Dario Di Luca; Roberta Rizzo
Journal:  Front Microbiol       Date:  2020-02-19       Impact factor: 5.640
  6 in total

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