Lies Lahousse1, Gijsbertus Ziere2, Vincentius J A Verlinden3, M Carola Zillikens4, André G Uitterlinden5, Fernando Rivadeneira5, Henning Tiemeier6, Guy F Joos7, Albert Hofman6, M Arfan Ikram8, Oscar H Franco6, Guy G Brusselle9, Bruno H Stricker10. 1. Department of Respiratory Medicine, Ghent University and Ghent University Hospital, De Pintelaan, Belgium. Departments of Epidemiology. 2. Departments of Epidemiology. 3. Departments of Epidemiology, Radiology, and. 4. Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. Netherlands Consortium on Healthy Aging (NCHA), Leiden, The Netherlands. 5. Departments of Epidemiology, Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. Netherlands Consortium on Healthy Aging (NCHA), Leiden, The Netherlands. 6. Departments of Epidemiology, Netherlands Consortium on Healthy Aging (NCHA), Leiden, The Netherlands. 7. Department of Respiratory Medicine, Ghent University and Ghent University Hospital, De Pintelaan, Belgium. 8. Departments of Epidemiology, Radiology, and Netherlands Consortium on Healthy Aging (NCHA), Leiden, The Netherlands. Departments of Neurology and. 9. Department of Respiratory Medicine, Ghent University and Ghent University Hospital, De Pintelaan, Belgium. Departments of Epidemiology, Respiratory Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. 10. Departments of Epidemiology, Netherlands Consortium on Healthy Aging (NCHA), Leiden, The Netherlands. Inspectorate of Healthcare, The Hague, The Netherlands. b.stricker@erasmusmc.nl.
Abstract
BACKGROUND: Despite frailty being an important geriatric syndrome, its prevalence and associated mortality risk in older patients with chronic obstructive pulmonary disease (COPD) are unknown. METHODS: We examined the relationship between COPD confirmed by spirometry, COPD severity, and frailty defined by the Fried criteria within 2,142 participants (aged 74.7 ± 5.6 years) of the Rotterdam Study, a prospective population-based cohort study. RESULTS: The frailty prevalence was significantly higher (p < .001) in participants with COPD (10.2%, 95% CI: 7.6%-13.5%) compared with participants without COPD (3.4%, 95% CI: 2.6%-4.4%). Adjusted for age, sex, smoking, corticosteroids, and other confounders, participants with COPD had a more than twofold increased prevalence of frailty (odds ratio 2.2, 95% CI: 1.34-3.54, p = .002). The prevalence was highest when severe airflow limitation, dyspnea, and frequent exacerbations were present. Participants with mild airflow limitation were more frequently prefrail. COPD elderly who were frail had significant worse survival. CONCLUSIONS: This population-based cohort study in elderly demonstrates that COPD is associated with frailty even after adjusting for shared risk factors. Our findings suggest that frailty-in addition to COPD severity and comorbidities-identifies those COPD participants at high risk of mortality.
BACKGROUND: Despite frailty being an important geriatric syndrome, its prevalence and associated mortality risk in older patients with chronic obstructive pulmonary disease (COPD) are unknown. METHODS: We examined the relationship between COPD confirmed by spirometry, COPD severity, and frailty defined by the Fried criteria within 2,142 participants (aged 74.7 ± 5.6 years) of the Rotterdam Study, a prospective population-based cohort study. RESULTS: The frailty prevalence was significantly higher (p < .001) in participants with COPD (10.2%, 95% CI: 7.6%-13.5%) compared with participants without COPD (3.4%, 95% CI: 2.6%-4.4%). Adjusted for age, sex, smoking, corticosteroids, and other confounders, participants with COPD had a more than twofold increased prevalence of frailty (odds ratio 2.2, 95% CI: 1.34-3.54, p = .002). The prevalence was highest when severe airflow limitation, dyspnea, and frequent exacerbations were present. Participants with mild airflow limitation were more frequently prefrail. COPD elderly who were frail had significant worse survival. CONCLUSIONS: This population-based cohort study in elderly demonstrates that COPD is associated with frailty even after adjusting for shared risk factors. Our findings suggest that frailty-in addition to COPD severity and comorbidities-identifies those COPDparticipants at high risk of mortality.
Authors: Lauren R Pollack; Nathan E Goldstein; Wendy C Gonzalez; Craig D Blinderman; Mathew S Maurer; David J Lederer; Matthew R Baldwin Journal: J Am Geriatr Soc Date: 2017-03-06 Impact factor: 5.562
Authors: Cassie C Kennedy; Paul J Novotny; Nathan K LeBrasseur; Robert A Wise; Frank C Sciurba; Roberto P Benzo Journal: Ann Am Thorac Soc Date: 2019-02
Authors: Panaiotis Finamore; Martijn A Spruit; Jos M G A Schols; Raffaele Antonelli Incalzi; Emiel F M Wouters; Daisy J A Janssen Journal: Aging Clin Exp Res Date: 2020-04-11 Impact factor: 3.636
Authors: M Arfan Ikram; Guy G O Brusselle; Sarwa Darwish Murad; Cornelia M van Duijn; Oscar H Franco; André Goedegebure; Caroline C W Klaver; Tamar E C Nijsten; Robin P Peeters; Bruno H Stricker; Henning Tiemeier; André G Uitterlinden; Meike W Vernooij; Albert Hofman Journal: Eur J Epidemiol Date: 2017-10-24 Impact factor: 8.082